Pejkovska, Sava
Preferred name
Pejkovska, Sava
Official Name
Pejkovska, Sava
Translated Name
Пејковска С.
Alternative Name
S.Pejkovska
Pejkovska S.
Sava Pejkovska
Sava, Pejkovska
Пејковска С.
С.Пејковска
Пејковска Сава
Сава Пејковска
Main Affiliation
39 results
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Item type:Publication, Role and Significance of Markers of Inflammation in the Asthmatic Disease(ID Design 2012/Scientific Foundation SPIROSKI, 2015-12-15); BACKGROUND: Asthma is characterized by airway inflammation which can be reversible. AIM: Investigation the importance of eosinophils, ECP and IL-5 in asthmatics versus patients with obstructive bronchitis and healthy subjects. We investigated the values before and after the treatment in asthmatics. MATERIAL AND METHODS: We studied 77 subjects divided in three groups as follows: 1) asthma patients; 2) patients with obstructive bronchitis and 3) control group of healthy subjects. In all the subjects there were determined: Total number of eosinophils (Eo), eosinophilic cationic protein (ECP), Interleukin 5 (IL-5) and allergy tests. RESULTS: The total number of eosinophils was significantly increased in the group of asthma patients versus second and third group. We found that the presence of ECP demonstrate an ongoing inflammation, with or without clinical symptoms of asthma patients. There was significant difference between the values of ECP of asthma patients versus second and third group. Our results have shown that IL-5 was significantly increased versus second group and controls (p < 0.01). We also found the decrease of the values of inflammatory markers after the treatment with corticosteroids. CONCLUSIONS: Eosinophils, ECP and IL-5 could be useful markers for selecting allergic patients and could be the monitors of treatment effects - Some of the metrics are blocked by yourconsent settings
Item type:Publication, BODY MASS INDEX AS A DETERMINANT OF OUTCOME OF TREATMENT WITH NON-INVASIVE VENTILATION IN PATIENTS WITH RESPIRATORY FAILURE DUE TO ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE(Macedonian Association of Anatomists and Morphologists, 2015-12); ; ; Arbutina SIntroduction: In the last two decades noninvasive ventilation (NIV) has become an integral part of the protocol for the treatment of patients with acute respiratory failure. Aim of the study: To assess the relationship between body mass index (BMI) and outcome of treatment with NIV in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Material and methods: A total of 52 patients, over the age of 40, hospitalized because of acute exacerbation of COPD and treated with NIV were prospectively recruited. The patients were divided into two groups: 1) successful NIV treatment group; 2) failed NIV treatment group. Results: There was no significant difference in distribution between the two patients groups in terms of sex and age. Compared to group 1, in the group 2, difference was observed in the values of GCS that were lower, and the PaCO2 and APACHE II scores were higher, but the difference between the two groups was not significant (p> 0.05). Significant difference was observed between the values of pH (p <0.05) and BMI (p <0.01). The majority of patients with NIV treatment failure were with BMI <22kg / m2. Conclusion: The degree of acidosis and BMI are factors of statistical significance for the outcome of NIV treatment. Further studies are needed to clarify the reasons for the association between NIV and low BMI. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The rationality of the use of NIV in elderly patients with acute COPD exacerbation(European Respiratory Society, 2018-09-15); ; ; ; Jovanoski, Smilko - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Predictive Factors for the Effect of Treatment by Noninvasive Ventilation in Patients with Respiratory Failure as a Result of Acute Exacerbation of the Chronic Obstructive PulmonaryDisease(ID Design 2012/Scientific Foundation SPIROSKI, 2015-11-11); ; ; Jovanovska Janeva E.BACKGROUND: Noninvasive mechanical ventilation (NIV) applies ventilator support through the patient’s upper airway using a mask. AIM: The aim of the study is to define factors that will point out an increased risk of NIV failure in patients with exacerbation of Chronic Obstructive Pulmonary Disease (COPD). PATIENTS AND METHODS: Patients over the age of 40, treated with NIV, were prospectively recruited. After data processing, the patients were divided into two groups: 1) successful NIV treat-ment group; 2) failed NIV treatment group.RESULTS: On admission arterial pH and Glasgow coma scale (GCS) levels were lower (pH: p<0.05, GCS: p<0.05), and Acute Physiology and Chronic Health Evaluation II (APACHE) score and PaCO2were higher (p<0.05) in the NIV failure group. Arterial pH was lower (p<0.05) and PaCO2and respiratory rate were higher (p<0.05) after 1h, and arterial pH was lower (p<0.05) and PaCO2(p<0.05), respiratory and heart rate were higher (p<0.05) after 4h in the NIV failure group.CONCLUSION: Measurement and monitoring of certain parameters may be of value in terms of predicting the effectiveness of NIV treatment.IntroductionChronic Obstructive Pulmonary disease (COPD) is one of the commonest diseases in the world. It is an increasing international health problem with a projected third leading cause of mortality within the adult population[1]. Chronic obstructive pulmo-nary disease is a respiratory disorder largely caused by smoking, and is characterized by progressive, par-tially reversible airway obstruction and lung hyperinfla-tion, systemic manifestations, and increasing fre-quency and severity of exacerbations. An acute exac-erbation is defined as a sustained worsening of dysp-nea, cough or sputum production leading to an in-crease in the use of maintenance medications and/or supplementation with additional medications[2]. The management of the acute exacerbations of COPD accounts for a large proportion of the health care costs because of the need for prolonged hospitaliza-tions and increased rate of mortality[3]. An important event in the course of the disease is the shortening of the inspiratory time, leading to a decrease of the Total Lung Capacity (TLC) and increase of the respiratory rate. The management which aims to increase the TLC with subsequent increase in the alveolar ventila-tion, as well as the decrease of the respiratory rate, is expected to reverse the impaired respiratory physiolo-gy[4]. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Systemic inflammatory profile in patients with chronic obstructive pulmonary disease(Macedonian Association of Anatomists and Morphologists, 2024-05-01); ; ; Chronic obstructive pulmonary disease(COPD)is heterogeneous condition with various phenotypes that have their own pathogenetic mechanisms and certain inflammatory mediators, as C-reactive protein, interleukins, circulating leukocytes. Uncovering the inflammatory profile may identify disease biomarkers. We aimedto compare the values of systemic inflammatory parameters in patients with different clinical phenotypes and determine their correlation with clinical parameters.In 30 COPD patients weanalyzeddemographic and clinical data, history of allergies, cigarette smoking and history of exacerbations. We phenotyped them intonon-exacerbator, exacerbator and COPD with asthma phenotype. COPD assessment test, modified dyspnea scale and the BODE (Body mass index, Obstruction, Dyspnea, Exercise capacity) index werecalculated. Spirometry and lung X-ray were performed. Peripheral blood was taken for analysis of inflammatory parameters.There were 16 patients(53.33%) with phenotype of non-exacerbator, and 7 (23.33%) with exacerbatorand COPD with asthma phenotype each. COPD assessment testhadsignificantly lowestvalue in non-exacerbator and modified dyspnea scalesignificantly highest value in exacerbatorphenotype. Therewere no mild gradepatientsin exacerbator,andno very severe grade in nonexacerbatorphenotype. C-reactive proteinand interleukin 8 had significantly lowest value in non-exacerbator; leucocytes significantly highest value in exacerbator; eosinophyls and interleukin 4 significantly highest value in COPD with asthma phenotype. There was no significant difference among the three phenotypes in neutrophyls andinterleukin 18. The three clinical phenotypes: non-exacerbator, exacerbator and COPDwith asthma have their own specific clinical and inflammatory features that have clinical, prognostic and therapeutic implications - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Aetiology(ID Design 2012/Scientific Foundation SPIROSKI, 2016-03-15); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation between detected respiratory pathogens and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(Македонско лекарско друштво = Macedonian medical association, 2021); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pulmonary embolism - Pulmonary thromboembolism in patient with rectal adenocarcinoma(Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia, 2024); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Efficacy of herbal medicines in treatment of respiratory infections(Macedonian Association of Anatomists and Morphologists, 2024-10-24); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Хроничен риносинузитис кај пациенти со астма и поврзаноста помеѓу синоназалната и бронхијална инфламација(Македонско лекарско друштво = Macedonian medical association, 2019-09);