Lazarova, Ana
Preferred name
Lazarova, Ana
Official Name
Lazarova, Ana
Alternative Name
Lazarova Ana
Лазарова Ана
Лазарова, А
Lazarova, A
Ана Лазарова
A.Lazarova
Lazarova A.
А. Лазарова
Лазарова А.
Main Affiliation
Email
anidinamita@gmail.com
17 results
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Item type:Publication, Value of MRI in multimodal treatment of locally advanced rectal carcinoma(Scientific Foundation SPIROSKI, 2020-07-16); ; MRI is a basic tool in patient selection for preoperative neoadjuvant treatment of rectal carcinoma, with assessment of stage reduction. The aim of the paper was to evaluate chemoradiotherapy effects in advanced stage rectal carcinoma by comparison of MRI findings before and after chemoradiotherapy. Material and methods: Prospectively, MRI findings of 15 patients with rectal carcinoma confirmed at colonoscopy, were evaluated. In all patients preoperative neoadjuvant treatment was done and MRI restaging was performed after 6 to 8 weeks. MRI standard protocol was done on 1.5T machine, sagital T2WI, axial T1WI, T2WI and DWI. On MRI was assessed tumor and nodal stage, presence of extra-mural vascular invasion (EMVI), tumor localization within the rectum (low, medium, high rectum, recto-sigmoid junction). Computer tomography was performed in all patients for distant metastases assessment. Results: Out of 15 patients, 12 (66.7%) were male, and 3 (33.3 %) were female, with a mean age of 65 years (range 50 to 80years). Six cases had middle rectum localization, 6 cases in low rectum, and 3 patients had recto-sigmoid localization. At initial MRI, 7 cases (46.6%) had MR signs for T3 stage, and 8 cases (53.3%) had T4 stage. Comparison of MRI results before and after chemoradiotherapy showed stage decreasing in 5(33.3%), from T4 to T3 stage. In 11 patients (73.7%), EMVI after therapy became negative with a statistically significant difference before and after chemoradiotherapy. All patients before therapy had different numbers of metastatic lymph nodes in mesorectum, with number reduction in all cases after therapy and two patients were without metastatic lymph nodes. Conclusion: MRI has a significant value in pre- and post-neoadjuvant therapy assessment of resection margins involved by tumor, positive extramural vascular invasion, and metastatic lymph node around resection margins. This is important for operative planning in order to avoid extensive resection with surgery techniques that preserve the anal sphincter. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Spontaneous omental infarction in an obese young female patient treated with laparoscopy: a case report(Oxford University Press (OUP), 2024-06); ; ; Argirov, IvanPartial infarction of the great omentum is a rare cause of abdominal pain and may present as a surgical emergency. Omental infarction might occur due to its torsion, but cases without obvious cause are reported. Risk factors related to this condition are overweight, obesity, abdominal trauma, recent abdominal surgery, hypercoagulability, postprandial vascular congestion and an increase in intra-abdominal pressure. Because of the condition's rarity, most patients are treated with surgery and the diagnosis is established intraoperatively. Preoperative diagnosis allows successful conservative treatment with analgesics and anti-inflammatory drugs. This case reports a young female patient with class III obesity presented with spontaneous partial infarction of the great omentum treated with laparoscopy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Case of Sister Mary Joseph’s Nodule Inpatient Who Underwent A Whipple Procedure(Crimson Publishers, 2020-12-16); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VALUE OF MRI IN MULTIMODAL TREATMENT OF LOCALLY ADVANCED RECTAL CARCINOMA(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2020-02-05); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREOPERTIVE STAGING OF RECTAL CARNCER WITH MRI(Medical faculty, Ss Cyril and Methodius University Skopje, 2018-03); Introduction: Rectal cancer is the third most common malignant disease worldwide with a high mortality rate in developed countries .. The magnetic resonance imaging method p lays a crucial role in the pre-operational staging of the rectal cancer. MR is a modality of choice for rectal cancer staging, which assists the surgeon in achieving negative resection margins. In fact, MR assists the surgeon in the planning of the type of surgical treatment, and also helps to predict the response to treatment and disease detection. Material and Methods: 61 patients '\lith c'olonoscopy proven rectal cancer have been treated treated with pre-ope_rative 1.5 T MRI of small pelvis in standard planes and pulse sequences (SAG T2, AX Ti, T2, DWI, COR STIR) Results: A tabular presentation of the results is given witch conelated the preoperative MR T staging with the pathohistological finding. The comparison was made in Tl, T2, T3 and T4 MR stadium with the acquired pathohistological stadium. The second table showing a percentage view of the difference between MR preoperative stadium and pathohistological results. Also a tabular presentation with general infom1ation for patients is given ; gender , nationality and age. Conclusion: MR as an ideal imaging method for preoperative staging for a local or advanced stage of rectal cancer. MR allows evaluation of extramural spreading, determines the mesorectal involvement and involves the margin of resection. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A RARE CASE OF MENINGEAL HEMANGIOPERICYTOMA ACCOMPANIED WITH INTRAOPERATIVE BLOOD LOSS(Department of Anaesthesia and Reanimation, Medical Faculty "Ss Cyril and Methodius", Skopje, R. Macedonia, 2020-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A Rare Case of Orbital Mucocele(CIENT PERIODIQUE, 2021-06-11)Orbital mucoceles are cysts which are filled with mucous fluid that cannot naturally drain from the nose. Most common arising from the ethmoid or frontal sinuses they grow and slowly cause mass effect of the adjacent orbital tissues. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Role of Contrast - Enchased Computer Tomography in the Management of Intestinal Obstruction(CIENT PERIODIQUE, 2021-06-10); Antonio GligorievskiIntestinal obstruction is a condition in which intestine is obstructed because of any mechanical or non-mechanical reasons. It accounts for 20% of all surgical admissions for acute abdomen. Computed tomography (CT) is currently the exam of choice for bowel obstruction because has higher specificity in reporting the etiology, site and grade of obstruction, and the presence of bowel ischemia, affecting the surgical decision. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE VALIDITY OF MAGNETIC RESONANCE IMAGING IN DETERMINING PREOPERATIVE T STAGE OF RECTAL CANCER(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R. Macedonia, 2020-06); Valjon SaliuIntroduction: The significance of preoperative staging of rectal cancer with magnetic resonance imaging is initial for the decision on further treatment of the disease, simple surgical or multimodal treatment at an advanced stage of rectal cancer. Aim of the Study: This paper demonstrates the validity of magnetic resonance imaging in determining the T stage of rectal cancer preoperatively, in correlation to the findings from the operative pathohistological material. Material and Methods: 82 patients aged from 43 to 87 years, with previously colonoscopy proven rectal cancer were treated in magnetic resonance imaging (MRI) – 1.5 T, standard pulls sequences were made: SAG T2, AX T1, AX T2, AX DWI and T stages were determinated. Results: The results obtained for the T stage with magnetic resonance are correlated to the pathohistological finding taken postoperatively as the gold standard in determining the sensitivity and specificity of magnetic resonance imaging. The sensitivity of MRI in determining the rectal cancer at T1 and T2 stage carcinomas was 86.7% and the specificity was 98.5%. The sensitivity of MR in determining T3 stage rectal cancers was 89.1% and the specificity was 88.9%. The sensitivity of MR in determining the T4 stage rectal cancers was 91.7% and the specificity was 92.9%. Conclusion: Magnetic resonance imaging is the gold standard in preoperative staging of rectal cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, IMPORTANCE OF EXTRAMURAL VASCULAR INVASION IN PREOPERATIVE STAGING OF RECTAL CANCER WITH MRI(Македонско лекарско друштво = Macedonian medical association, 2018-03-03); Introduction. Rectal cancer is the third most common malignant disease worldwide with a high mortality rate in developed countries. The prognosis of rectal cancer has been significantly improved over the past decade, and this is mainly due to progress in preoperative staging, which has been reflected in the therapeutic approach, where a significant change was made from simple surgical treatment to multimodal treatment. Although extramural vascular invasion (EMVI) is not included in the classical protocol for preoperative staging, itis a significant prognostic indicator of the recurrence rate. Methods. The study is a prospective one, and it included 61 hospital patients with previously proven rectal cancer, who had been operated on at the Department of Abdominal Surgery ofthe University Clinic for Surgical Diseases “St. Naum Ohridski” in Skopje, and who underwent a magnetic resonance staging preoperatively. Results. Comparison of extramural vascular invasion determined with MR preoperatively with pathohistological postoperatively obtained result. Conclusion. MR as an ideal imaging method in preoperative staging of rectal carcinoma. It is a tool that determines with high accuracy the extramural vascular invasion in patients with rectal cancer.