Petkovska, Lidija
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Petkovska, Lidija
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Petkovska, Lidija
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Item type:Publication, The Effect of Treatment on Short-Term Outcomes in Elderly Patients with Acute Kidney Injury(Scientific Foundation SPIROSKI, 2017-08-15); ; ; ; Elderly population (≥ 65) are more prone to develop acute kidney injury (AKI) compared to younger, also elderly with AKI have an increased requirement for dialysis treatment and an elevated risk of short-term and long-term mortality. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Multi-System Complications after Intravenous Cocaine Abuse(Scientific Foundation SPIROSKI, 2017-04-15); ;Chibishev, Andon ;Stevcevska, Aleksandra ;Smokovski, IvicaPetkovski, DusanUse and abuse of cocaine are associated with numerous adverse effects, independent of the route of administration. More severe conditions of poisoning, however, are observed after cocaine intravenous administration. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Severe mushroom poisoning in one Macedonian family(SAGE, 2015-09-05) ;Chibishev, Andon; ; ; Miletic, MilenaBACKGROUND: Collecting and consuming wild mushrooms is a historical tradition in many European countries, including The Republic of Macedonia. This activity is predominantly performed in the period between June and October, when the weather is warm and humidity in the air and soil is at higher levels.The Amanita genus consists of 500 different species of mushrooms; among these, Amanita phaloides, Amanita virosa and Amanita verna are most commonly found in oak forests in our country. These species are highly poisonous and because they can be similar to some edible mushrooms, they have often been misidentified. Their consumption causes severe intoxication. PURPOSE: The aim of this case series report is to demonstrate a severe poisoning with Amanita mushrooms (A. verna) that occurred in 8 patients, all from 1 Macedonian family. RESULTS: We show the differences in the clinical appearance and status of these patients, the wide spectrum of symptoms as well as the treatment and outcome of this rare poisoning. One patient, an 8-month-old baby, was excluded from the study because the infant was immediately transferred to the pediatric clinic after admission to our clinic. CONCLUSIONS: Despite modern therapy, poisoning due to ingestion of Amanita mushrooms is a serious clinical and health problem that may even be potentially lethal. The most efficient way for the general public to protect itself against potential poisoning is to avoid ingesting mushrooms that may not be edible. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Plasma apo/lipoproteins disturbances as a precondition for metabolic syndrome in HCV seronegative heroin addicts(Taylor & Francis, 2011-04-01); ;Bozinovska, Cvetanka ;Dimitrovski, Cedomir; Cibisev, AndonBackground: Dyslipidemia in heroin addicts is considered to be a precondition for developing metabolic syndrome. Objectives: The aim was to evaluate the frequency in serum lipid disturbances of hepatitis C virus (HCV) seronegative heroin addicts; the capacity of high-density lipoprotein (HDL)-C and apolipoprotein B (apoB)/apolipoprotein A-I (apoA-I) for predicting hypertriglyceridemia/low HDL-C profile; correlation of HDL-C with the apoB/apoA-I and their correlation to plasma apo/lipoproteins. Materials and methods: Sixty-six heroin addicts, seronegative for HCV and HIV, without liver morphological changes were divided into two groups according to their decreased/normal HDL-C concentrations. Results: We registered decreased HDL-C in 58.8% of the addicts; decreased apoA-I in 50.9%, increased triglyceride (TGL) in 35.9%, and increased apoB/apoA-I in 3.8% of the patients; and 25.7% had hypertriglyceridemia/low HDL profile. Addicts with low HDL-C had higher TGL (1.73 ± .91 vs. 1.31 ± .71, pр = .02) compared with addicts with normal HDL-C and the controls. Low HDL-C group had higher apoB/apoA-I compared with addicts with normal HDL-C (.62 ± .28 vs. .42 ± .11, pр = .000). HDL-C inversely correlated to apoB/apoA-I (p = −.452, pр = .001). ApoB/apoA-I showed stronger correlation with the observed apo/lipoproteins than the HDL-C. The logistic regression model showed that apoB/apoA-I index (OR 89.1, 95% CI 1.3–5971.2) is more significant predictor in developing hypertriglyceridemia/low HDL profile than HDL-C. Conclusion: Heroin addiction is associated with decreased plasma concentrations of HDL-C, apoA-I, apoB, and increased TGL concentrations. In heroin addicts, HDL-C concentrations are significantly associated with the apoB/apoA-I index, which correlates to all lipid fractions and is a stronger predictor of metabolic syndrome lipid profile in heroin addicts. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 254 Late complicationes of caustic injuries(Elsevier BV, 2003-09); ;Bozinovska, C. ;Naumovski, J. ;Pavlovski, B. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prooxidative/antioxidative Homeostasis in Heroin Addiction and Detoxification(SAP-Slovak Academic Press s.r.o., 2007); ; ;Bozinovska CBackground: Long-term heroin abuse is related to pathological changes in many organs mediated by oxidative stress (OS). Objectives: Estimation of systemic OS and antioxidant capacity in heroin addiction and detoxification provides information about prooxidant/antioxidant homeostasis in heroin misuse and need for antioxidant supplementation. Methods: OS was evaluated by the measurement of plasma reactive oxygen metabolites using spectrophotometric method and plasma lipid peroxidation by its end product--malondyaldehyd using Tiobarbituric Acid Reactions Substances method. The extracellular antioxidant capacity was estimated using OXY-adsorbent test. Results: This cross-sectional study includes 68 patients: 46 heroin addicts (20 patients on chronic heroin abuse, 19 patients on conventional method of detoxification and 7 patients on opioid antagonist--naltrexone (and 22 patients as a control) group. Increased OS was found in the heroin group (d-ROMs 349.3 +/- 102.2 UCarr, MDA 4.0 +/- 0.4 micromol/L) compared to the group on detoxification (d-ROMs 230.2 +/- 96.4 UCarr; MDA 3.6 +/- 0.3 micromol/L) and control group (d-ROMs 264.1 +/- 30.9 UCarr; MDA 3.7 +/- 0.2 micromol/L). TAC was decreased in the heroin group (324.5 +/- 75.0 micromol HClO/ml) and restored during conventional detoxification (371.8 +/- 25.1 micromol HClO/ml), but not completely in the group with naltrexone treatment (335.6 +/- 16.9 micromol HClO/ml) compared with controls (395.4 +/- 35.6 micromol HClO/ml). Conclusion: Long-term heroin abuse stimulates a progressive systemic oxidative stress which increases the extracellular antioxidants consumption and develops conditions for chronic heroin toxicity - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Impact of Post-Transplant Dysglycemia on Renal Allogrfat Function in Kidney Transplant Recipients on Cyclosporine-Based Immunosuppression(Македонско лекарско друштво / Walter de Gruyter GmbH, 2017-06-01); ; ; ;Petronijevic, ZvezdanaIntroduction.Post-transplant diabetes (PTDM), impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are common complications of immunosuppressive therapy (IT) and are associated with increased cardiovascular morbidity and impaired graft function (GF). Methods. Fifty-nine living donor kidney transplant recipients (KTR) were included in a combined cross-sectional and 8-month-observational prospective study about the impact of impaired glucose homeostasis (IGH) on GF. All patients were on standard IT including cyclosporine A (CsA), steroids and mycophenolate mofetil (MMF). In all patients a standard oral glucose tolerans test (OGTT) was performed. Results were classified according to the criteria of the American Diabetes Association: normal-with fasting blood glucose level (FGL) <5.6, IFG with FGL of 5.6-6.9, IGT with FGL of 7.8-11.1 and DM between > 6.9 FGL and >11 mmol/l. According to the results, all patients were divaded into two groups: Group 1 with impaired and Group 2 with normal GH. GF was estimated by GFR-Cockroft Gault (CG) and by degree of proteinuria in the beginning and end of the study.</jats:p> <jats:p><jats:bold>Results.</jats:bold> Twenty of 59(33.9%) patients showed overt IGH after transplantation while the remaining 39(66.1) were normal. The principal dysglycemia in KTR were PTDM (2 patients-3.3%), IGT (18 patients-30.5%) and IFG (7 patients-11.8%). In Group 1, postprandial glucose was higher (8.1±2.3 vs 5.8±0.7), more KTR were male (70% vs 33.3%), higher CsA levels were observed (160.9±81.2 vs 115.1±59.9) and time after the surgery was shorter (24.5±21.3 vs 41.4±28.). After a follow-up period of approximately 18 months in Group 1 a significant decline in GFR (62.6-52.7 ml/min) was noted, with no significant change in proteinuria. The correlation analysis was positive between CsA level and IGH and the time after transplantation and IFG. Conclusion.</jats:bold> Post-transplant dysglycemia and associated metabolic abnormalities are a significant factor for the deterioration of GF. CsA higher levels are associated with the occurrence of IGH and they affect the GF. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Anthropometric parameters and indexes in 9 year-old-children from R. North Macedonia(Macedonian Association of Anatomists, 2021-04-02); ; ; ; The aim of the study was the detection of sex-specific differences of anthropometric parameters and indexes that were used as indicators of growth and nutritional status in the 9-year-old-children from R.North Macedonia.The study included 280 healthy children aged 9 (140 boys, 140 girls) from R.North Macedonia. Fourteen anthropometric parameters were measured which define longitudinal, circular and transversal measures of skeleton using standard equipment and measurement technique. The following indicators were calculated: weight-for-age (BW), height-for-age (BH), BMI, mid-upper circumference-for-age (MUAC) and skinfolds thickness (scapula SFSc and triceps SFTr)-for-age.The results have shown significant sex-specific differences in favour of boys for the height, four transversal and three circular parameters, with exception of mid-upper-arm circumference and skinfolds that were apparently higer in girls. Values of the 50th percentile in boys were as follows: 33 kg for BW, 136 cm for BH and 17.65 kg/m2 for BMI, 19.8 cm for MUAC and for skinfolds: SFSc 8 mm and 12 mm for SFTr.The values of these parameters in girls were: 32 kg for BW, 135cm for BH and 17.47 kg/m 2 for BMI. 20.8 cm for MUAC and for SFSc 9.8 mm and 12.8 mm for SFTr .These results can be used as criteria for the assessment of the morphological characteristics and detection of deviations in the growth and nutritional status in children aged 9. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ACUTE PANCREATITIS AS ADVERSE REACTION ТО PERINDOPRIL THERAPY(2019); ; ; Many drugs and drug classes have been reported to be associated with acute pancreatitis. Angiotensin-converting enzyme inhibitors are one of the most commonly prescribed classes of medications, as they are used in hypertension, heart failure and proteinuria. Although well tolerated, acute pancreatitis has been reported in a few subjects treated with drugs from this group. We present a rare case of pancreatitis occurring as an adverse reaction to therapeutic doses of perindopril with good outcome. Case report: We report а case of a 63 year-old-woman presented with clinical signs of acute pancreatitis, 2 months after administration of perindopril 4 mg once daily for treatment of hypertension and reduction of proteinuria. The patient has had a 3-year-history of diabetes treated with metformin 2 x 850 mg daily, which is also classified as a possible drug that causes pancreatitis. Other causes of the disease were ruled out. After cessation of perindopril her clinical status improved and pancreatic enzymes level decreased. Conclusion: Because perindopril has a widespread clinical use, we wish to alert clinicians and urge close monitoring for pancreatitis as well as other adverse effects. Discontinuation of the drug leads to an improvement in the clinical condition.
