Krsteska, Blagica
Preferred name
Krsteska, Blagica
Official Name
Krsteska, Blagica
Translated Name
Крстеска, Благица
Alternative Name
Dukova, Blagica
Krsteska, B
Dukova, B
Main Affiliation
Email
blagicadr@yahoo.com
blagicadr@gmail.com
Researcher ID
0000-0001-8610-9119
40 results
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Item type:Publication, Radiation-induced rectal leiomyosarcoma in a cervical cancer survivor: a case report(Oxford University Press (OUP), 2025-08); ; Rectal leiomyosarcoma (LMS) is an exceptionally rare malignancy, representing ˂0.5% of all rectal cancers. Even more uncommon are the cases of radiation-induced LMS arising as an independent malignancy following pelvic radiotherapy. We report a case of a 56-year-old female patient with a history of high-grade large cell neuroendocrine cervical carcinoma treated 12 years earlier with radical hysterectomy and adjuvant chemoradiotherapy. The patient presented with rectal discomfort and altered bowel habits. A colonoscopy revealed a near-obstructing polypoid rectal mass, and a biopsy confirmed LMS. Surgical treatment via abdominoperineal resection with total mesorectal excision was performed. Adjuvant chemotherapy was conducted by an oncologist. Given the long latency period and absence of metastases, the tumor was stated as a radiation-induced primary malignancy. This case emphasizes the importance of awareness in cancer survivors previously treated with pelvic radiotherapy and highlights the critical role of surgery in the management of rectal LMS. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synchronous occurrence of ileal stromal tumor (GIST) and colonic adenocarcinoma: a case report.(2015); ; ; Introduction: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. There is an increasing number of literature reports on synchronous occurrence of gastrointestinal stromal tumors and another malignancy of distinct etiology and evolution. The most reported cases include gastric synchronous occurrence of gastrointestinal stromal tumors and adenocarcinoma and gastric gastrointestinal stromal tumors and colonic adenocarcinoma. Case report: We present a case of a 77-old female, with synchronous cecal moderately differentiated adenocarcinoma in Stage IIA according to the TNM classification and ileal spindle cell type GIST with low malignant potential, positive for c-Kit, CD34, vimentin, Actin, and negative for S100. Conclusion: The synchronous occurrence of small bowel gastrointestinal stromal tumors and other primary gastrointestinal malignancies has been rarely reported. There is a need of further investigations to identify the relationship between gastrointestinal stromal tumors and colorectal cancers. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pigmented papillary carcinoma of male nipple mimicking melanoma(Springer, 2021-08-31); ; ; ; Background and objective: Primary melanomas of breast and carcinomas with pigment rich melanocytes are well known entities. Melanoma in nipple-areola complex is extremely rare and in differential diagnosis must be distinguished between Paget disease, melanoma from extramammary sites and other invasive carcinomas. We present a case of invasive papillary carcinoma of male nipple with melanin laden tumor cells. Methods: A 71-year old male patient presents with lobulated grayish tumor of the right nipple measuring 2x1, 3 cm elevated above the skin surface 1cm. The lesion was surgically removed with skin excision 0,7x 0,5x 0,5cm. The specimen was formalin-fixed and paraffin-embedded, routinely stained with HE. Additional immunohistochemical analysis was performed with CK7, ER, SMA, S-100, and Melan A. Results: The gross specimen on cut sections revealed solid white to brown tumor, well demarcated at the base and ulceration of overlying epidermis. Histomorphology of the sections showed papillary structures with tall columnar cells overlying fibrovascular cores, as well as micropapillary formations. There were areas of solid and cribriform growth pattern. Microcalcifications were diffusely present. There were accumulated melanophages in subepithelial tissue and melanin granules were also found in tumor cells. Immunohistochemical analysis showed that tumor cells were positive for CK7, with strong and diffuse nuclear stain for ER, with complete absence of myoepithelial cell on SMA stain. Melan A and S-100 were negative. Although rare, a diagnosis of pigmented papillary carcinoma was made. Conclusion: Pigmented carcinomas of breast are rare. When they are localized in areolar region the diagnosis should be carefully made to exclude lesions with melanocytic differentiation. The pigmentation should be considered also as a result by proximity to epidermis. The distinction between benign and malignant papillary lesions is quite difficult in most cases. The prognosis of patients with papillary carcinoma is relatively favorable. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Plasmacytoma of the testis as initial presentation of multiple myeloma: case report(2022-09); ; Background & objectives: Extramedullary plasmacytoma represents 5% of plasma cell neoplasms. Plasmacytoma of the testis is extremely rare and may occur as isolated tumour or in concomitance with multiple myeloma. We report a case of testicular plasmacytoma in 77-year-old male patient. Methods: The physical examination and ultrasonography revealed enlarged left testicle. Based on a clinical diagnosis, an inguinal orchidectomy was performed. On gross examination the testicle measured 7x4x4cm and was entirely occupied by a solid white fleshy tumour. Formalin fixed, paraffin embedded tissue samples were stained with HE and immunohistochemically with CD138, MUM 1, CD79, CD3, CD20, CD117, PLAP and Ki 67. Results: Microscopic examination revealed a malignant neoplasm composed of atypical plasma cells with pale eosinophilic cytoplasm and polymorphic and polychromatic nuclei which diffusely obliterated underlying testicular parenchyma and infiltrating the epididymis and surrounding peritesticular fibrous tissue. Immunohistochemically the cells were positive for CD138, MUM1 and CD79 and negative for CD3, CD20, CD117 and PLAP with Ki67 80%. After period of two and half months the diagnose of multiple myeloma was established with bone marrow aspiration showed 60% plasma cells, flow cytometry with CD38 and CD138 plasma cells and serum protein immunoelectrophoresis IgA idiotype. Patient died after two-week therapy with corticosteroids, four months after initiate diagnose of plasmacytoma of testis. Conclusion: Testicular plasmacytoma is extremely rare presentation of extramedullary plasmacytoma. Taking into account the additional data obtained about the patient we concluded that in our case it was the first manifestation of systemic disease referred as multiple myeloma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Incidence of Urinary Tract Tumours in a Two-Year Period (2010-2011) at the Institute of Pathology, Faculty of Medicine, Skopje, Macedonia(Walter de Gruyter GmbH / MANU, 2014); ; ; ; Bodganovska-Todorovska, MagdalenaWe performed a retrospective analysis of tumours of the kidneys and the lower urinary tract diagnosed at the Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, in a two-year period (2010-2011), with the aim of highlighting the main morphological characteristics and to present the statistical features of these tumours. All the cases were diagnosed on paraffin sections from surgical specimens routinely stained with H&E, and immunohistochemically with a panel of monoclonal antibodies. The analysis revealed a total of 755 cases, of which 166 (14%) were located in the kidney including the renal pelvis, and 649 (86%) were tumours of the urinary bladder. Twelve of the renal tumours (11.3%) were benign, and the rest were malignant tumours. Most of them were adenocarcinomas (n=77; 72.6%) and 17 cases (16%) were transitional cell carcinomas originating from the renal pelvis. The analysis of the lower urinary tract tumours showed a strong prevalence of malignant urothelial tumours (96%), with a male to female ratio of almost 4:1. Low grade morphology was a predominant feature (71.7%) and 51 cases (22.9%) were of high grade. The percentage of urothelial tumours of the kidney in our series is higher than in most of the reported series, which should lead to an expanded analysis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Granular cell tumor of the breast: a case report and review of literature(BioMed Central, 2009-08-10); A 22-year-old female patient presented with a breast mass lesion with a clinical suspicion of a fibroadenoma. Histological evaluation revealed a rare benign neoplasm - granular cell tumor. Granular cell tumor is rare neoplasm that may arise in virtually any body site, and in 5% it occurs in the breast. The histogenesis of this tumor is still rather controversial and currently the most acceptable theory is a Schwann cell origin. The main histological feature is granular cytoplasm of the tumor cells. From a clinical point of view there is a similarity between granular cell tumor and mammary carcinoma on mammography and ultrasound. Pathohistologically, sometimes, differential diagnostic difficulties exist concerning apocrine carcinoma, histiocytic lesions and metastatic neoplasms. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Small intestine metastasis from endometrial carcinoma initially presented as enterocutaneous fistula: a case report and literature review(Oxford University Press (OUP), 2024-05); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A true epidermotropic apocrine neoplasm in the form of perianal Paget's disease: a case report.(BioMed Central, 2013-06-20); ; ; Introduction Extramammary Paget’s disease is an uncommon intraepithelial neoplasm that arises in areas rich in apocrine glands. Treatment includes wide surgical excision and nonsurgical modalities. We present the case of a patient with perianal Paget’s disease with no recurrent disease after wide surgical resection. Case presentation Our patient was a 46-year-old man of Macedonian ethnicity who presented with a pruritic perianal lesion measuring up to 6cm without pain or bleeding. Two biopsies and a perianal wide surgical excision were performed. The tissue specimens were formalin-fixed and the paraffin-embedded samples analyzed according to standard histochemical and immunohistochemical procedures. Surgical perianal skin excision revealed diffuse eczematoid, whitish plaques. Pathohistology showed Paget cells infiltrating his epidermis and adnexal epithelium, with ulceration. Immunohistochemical analysis revealed positive Paget cell expression for cytokeratin 7, epithelial membrane antigen, carcinoembryonic antigen, androgen receptor and human epidermal growth factor receptor 2, and negative expression for cytokeratin 20 and melan-A. Conclusion Paget’s disease is a rare disorder that should be considered in the differential diagnosis of perianal lesions. Reporting cases of extramammary Paget’s disease is crucial for diagnostic guidelines and different therapeutic options. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation of Immunohistochemistry and Fluorescence in Situ Hybridization for HER-2 Assessment in Breast Cancer Patients: Single Centre Experience(ID Design 2012/DOOEL Skopje, 2018-04-15); ; ; ; BACKGROUND: Accurate assessment of HER-2 is imperative in selecting patients for targeted therapy. Most commonly used test methods for HER-2 are immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH). We evaluated the concordance between FISH and IHC for HER-2 in breast cancer samples using Food and Drug Administration approved tests. MATERIAL AND METHODS: Archived paraffin tissue blocks from 73 breast cancer patients were used. HER-2 immunostaining was performed using Ventana anti–HER-2 monoclonal antibody. The FISH assay was performed using PathVysion™ HER-2 DNA Probe Kit. RESULTS: Of the 73 cases 68.5% were IHC 0/1+, 15.07% were IHC 2+ and 16.44% were IHC 3+. Successful hybridisation was achieved in 72 cases. HER-2 FISH amplification was determined in 16.67% cases. Ten IHC 3+ and two IHC 2+ cases were FISH positive. Two of the IHC 3+ cases were FISH negative. Concordance rate was 100%, 18.18% and 83.33% for IHC 0/1+, 2+ and 3+ group, respectively. Total concordance was 84.72%, kappa 0.598 (p < 0.0001). The sensitivity of IHC in detecting IHC 2+ and IHC 3+ cases was 16.7% and 83.3%, and the specificity was 85% and 96.67%, respectively. CONCLUSION: The consistency between the methods was highest for IHC negative and lowest for IHC equivocal cases. The immunohistochemistry showed high sensitivity for IHC 2+/3+ cases and high specificity for IHC 3+ cases. Our results support the view that false-positive rather than false-negative IHC results are a problem with HER-2/IHC testing, and that IHC should be used as an initial screening test, but IHC 2+/ 3+ results should be confirmed by FISH. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synovial sarcoma of the liver - a case report(Scientific Foundation SPIROSKI, 2011-06-15); ; Jovcevski, AlenWe report a case of synovial sarcoma of liver in a 44 year old man, presented as a tumor mass in left hepatic lobe. The patient was admitted at the hospital with clinical symptoms of acute abdomen and severe pain in the right upper quadrant. Imaging examinations showed a tumor mass in the left hepatic lobe and free liquid in the abdominal cavity, due to the rupture of the tumor. A resection of 2 segments of the left hepatic lobe, where the tumor was located, was performed. Morphological, immunohistochemical and FISH studies confirmed the diagnosis of monophasic synovial sarcoma. Additional clinical and imaging examinations, made after the surgery, did not confirm tumor mass in any other localization. The patient refused any therapy other than surgery, at that time. A relapsing tumor mass was found 6 months later and another surgical intervention was done. The patient received five monotherapy cycles of Doxorubicin, 75 mg/m2, after the second surgical intervention. He is still alive 11 months after the first operation receiving the same therapy and having second relapsing inoperable tumor mass filling the retroperitoneal space and a great fraction of the abdominal cavity.