Bogdanska, Jasna
Preferred name
Bogdanska, Jasna
Official Name
Bogdanska, Jasna
Main Affiliation
52 results
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Item type:Publication, Protein za prijenos kolesteril estera (CETP) i veličina čestica LDL u bolesnika s koronarnom bolešću(CROATIAN ATHEROSCLEROSIS SOCIETY, CROATIAN MEDICAL ASSOCIATION, 2019-05); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE MOST COMMON DISORDERS OF THE HAND ASSOCIATED WITH CARPAL TUNNEL SYNDROME IN ADULTS(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2021); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Radiosynthesis of perfluorooctanesulfonate (PFOS) and perfluorobutanesulfonate (PFBS), including solubility, partition and adhesion studies(Elsevier, 2012-01-27); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Tissue distribution of 14C-labelled perfluorooctanoic acid in adult mice after 1-5 days of dietary exposure to an experimental dose or a lower dose that resulted in blood levels similar to those detected in exposed humans(Elsevier, 2020-01); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prevalence of metabolic syndrom in patients with psoriasis(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2019); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphological and biochemical changes in Wistar rat livers after clofibrate treatment(Macedonian Association of Anatomists, 2018); ; ; ; The aim of our study was to determine whether short-term administration of clofibrate can lead to morphological changes in the Wistar rat livers and weather these changes were accompanied by changes in the specific activity of the enzymes involved in oxidative stress. Male Wistar rats divided in two groups: control and experimental were treated with saline solution and clofibrate respectively (250 mg/1000 g/day) for 12 days. Tissue liver samples were taken for morphological examination and liver homogenates and sub-cellular fractions were used for measurement ofproteins, reactive oxygen species (ROS) producing and ROS scavenging enzyme activities. Following clofibrate treatment, liver histopathology in the treated group has shown deranged liver architecture, focal necrosis and presence of atypical lymphocytes.Electron light mitochondrial matrix and increased number of peroxisomes and mitochondria were also observed. These changes were accompanied by increase of the specific activity of ROS producing enzymes (urate oxidase and palmitoyl CoA oxidase). The most prominent increase of the activity with the increase of relative sub-cellular distribution was observed in the peroxisomal fraction (LMF). Specific activity of catalase was increased, whereas superoxide dismutase and glutathione peroxidase have shown almosta double decrease. Morphological changes in the liver accompanied by ROS production which has prevailed over their removal pointed to a conclusion that clofibrate can cause morphological changes accompanied by biochemical changes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Quality management: illuminating the path to ISO 15189 accreditation - A view from the Republic of North Macedonia(Turkish Biochemical Society, 2019); ; ; In the Republic of North Macedonia the work of the diagnostic medical laboratories is regulated by the Law of Health Care. There is an urgent need for better development of an evidence-based, scientific, and sustainable national strategy for the improvement of health laboratory service. Clear indicators of improvement must be established. A key indicator should be the number of laboratories that have achieved, and can maintain accreditation. The Macedonian Society of Medical Biochemistry and Laboratory Medicine (MSMBLM) recommends that the quality system established meet the requirements of the International Standard for medical laboratories (‘Medical laboratories: Requirements for quality and competence ’[EN ISO 15189:2012]), which has been accepted as the fundamental standard for the accreditation of medical laboratories in European countries. EN ISO 15189 was developed as a baseline standard for the Quality Management System (QMS) in medical laboratories and is recognised as the connecting standard for all disciplines in laboratory medicine. With the acceptance of the ISO standard, the need of countries for their own QMS for laboratory medicine no longer existed. In 2013, the Standardisation Institute of the Republic of North Macedonia accepted the standard as the Macedonian norm for quality assessment of medical laboratories (MKS EN ISO 15189:2013). MSMBLM, as the professional society of specialists in medical biochemistry, is responsible for the translation of international guidelines into national guidelines. These guidelines have to be in agreement with the standard EN ISO 15189. For that purpose, cooperation between MSMBLM and the National Accreditation Body (Institute for accreditation of the Republic of North Macedonia), as well as cooperation between international medical laboratory organisations, such as International Federation of Clinical Chemistry (IFCC), European Federation of Laboratory Medicine (EFLM) and international accreditation bodies, such as International Laboratory Accreditation Cooperation (ILAC) is essential. The accreditation of Macedonian medical laboratories is not mandatory; the decision for accreditation is voluntary. Accreditation is accessible to every client submitting an accreditation application to the Institute of Accreditation, which has been a member of ILAC since 2008. In 2013, the first medical biochemistry laboratory was accredited in the country. So far, nine medical laboratories have been accredited according the MKS EN ISO 15189:2013. Four of them are public sector laboratories. Flexible scope is not yet started for the ISO 15189 accreditation process in North Macedonia. The medicalized steps, including test’s selection advice and interpretation of results are not included in accreditation process. Diagnostic laboratories of the Institute of pathology, Medical Faculty-Skopje and Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov (Macedonian Academy of Sciences and Arts) are also using ISO 17025 as additional standard. The low number of accredited laboratories could be the result of the shortage of financial resources, poor government attention to laboratory service, the shortage of qualified personnel and/or the lack of a national laboratory policy. The experiences of laboratory professionals from accredited laboratories, who have a high level of knowledge, skills, and competence, are crucially important to the process of developing a competent laboratory service within the national health system. The implementation of the Laboratory Quality Management system (LQMS) requires support of laboratories by the MSMBLM and close collaboration between specialists in laboratory medicine (medical biochemistry), technical assessors, and consultants. Each of them will give a different perspective on what should be prioritised. Implementation of a QMS should be a stepwise process but it is necessary to start with changes that can be easily accomplished and have the biggest impact. All quality essentials must be addressed. Appropriate laboratory facilities, infrastructure, and equipment for each laboratory tier level are essential to enable safely and efficient performance. Strong programs supporting quality assurance, quality control, and quality improvement should exist. They are fundamental for the establishment, maintenance and improvement of laboratory quality systems. SOPs must be well-written, understood, and implemented; laboratory personnel should routinely perform IQCs; and laboratories must be required to participate in EQA or proficiency testing (PT) programmes. Future directions: The globalisation of markets and migration of health professionals requires improving the laboratory diagnostic process. A quality laboratory system is the foundation of a strong national health system. Laboratory workforce, infrastructure, and quality management system are vital for the delivery of quality laboratory services. Coordination with the Ministries of Education and Health is essential for maintaining standards of education and levels of knowledge. The competency of laboratory professionals has to be maintained through mandatory participation in continuous medical education (CME). For Government, Ministry of Health, professional association(s) and stakeholders, accreditation of medical laboratories according to ISO 15189:2012 should be a high priority. They should act together and undertake coordinated efforts to integrate accreditation programs into national health policy, planning, and health development programmes. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Plasma levels of ApoB, ApoA1, and Apo B/A1 ratio are associated with coronary artery disease(Turkish Biochemical Society, 2019-10); ; ; ; Irena Kostovska - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Medical biochemistry as a monovalent specialization in the Republic of Macedonia - present situation(Macedonian Association of Anatomists, 2018); ; ; Clinical Chemistry (Medical Biochemistry) practice as a subdiscipline of laboratory medicine in the Republic of Macedonia is regulated by the Ministry of Health according to the Law on Health Protection of the Republic of Macedonia, and was established for the first time in 1960.The four year Specialization Syllabus according to the EU4 Directive was introduced in 2008 and is still in force. Eligible to enter the specialization program are medical doctors and pharmacists. Completing the specialization program and the final exam are requirements for issuing the license for independent clinical chemistry practice by the Macedonian Doctor’s Chamber.The common training meets the requirements for the perspective professional movements across EU borders for the medical doctors and pharmacists (the length of total education is 10 years). In the era of the new analytical techniques, use of statistics, it will be of a great importance to update the present syllabus according to the fifth version of the European Syllabus for post graduate training for specialists in Laboratory Medicine and the needs of our country. The revised training program should call attention towards the structure of the program, as well as towards the expected responsibilities of trainees and trainers and the strategies of our country. The Medical Faculties providing the training in medical biochemistry in the Republic of Macedonia, as well as the professional societies should be included in updating the syllabus in order to have equally trained professionals who can face the new requirements in laboratory medicine in the Republic, but also qualified specialists prepared for the free movement across the European Union borders in the future. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EVALUATING ASSAY PRECISION FOR IMMUNO-CHEMILUMINESCENT METHOD FOR FOLLICLE-STIMULATINGHORMONE (FSH)(Walter de Gruyter GmbH, 2017-01-01); ; ; ; Verification process of the methods according to the needs of ISO 17025 Standard includes evaluating the imprecision of theassay(S). For this purpose it is necessary to assess the repeatability (within-run) and total within-run laboratory precision.According to the CLSI EP15-A2 document the user of the test(s) should undertake the measurements of the analyte(s) at at-least two levels, by running of three replicates over five days. The purpose of our work was to estimate the assay precision ofthe immune-chemiluminiscent method for FSH quantification by estimating of repeatability and within-laboratory precisionas well as, to evaluate the obtained results.Material of our study were control samples, different from those used to ensure that the instrument is in control at the timeof the assessment, with two levels (low and high), which were run in duplicate as three replicates for 5 consecutive daysusing Immulite/Immulite 1000 Simens kits. The repeatability value for the low replicates was 0.30 miU/ml and for the highreplicates 2.1 miU/ml. Estimated repeatability value for the high level was less than the manufacturer’s verification valueclaims (2.1 and 2.5 respectively). Estimated repeatability verification value for the low level of replicates is similar to theverification value of the manufacturer’s claim (0.3 and 0.27 respectively). Estimated within-laboratory precision for the lowreplicates was 0.6 miU/ml and for the high 3.32 miU/ml.Evaluated within-laboratory precision verification value for the low replicates was 0.42 that is less than the manufacturer’sclaimed verification value of 2.68. For the high level replicates evaluated verification value was 2.67 less than themanufacturer’s claim (13.88).Our data have confirmed that the method is suitable for the purposes of the Standard and that repeatability and within-laboratory precision verification values are consistent with the manufacturer’s claims.