Kulevanova, Svetlana

Preferred name

Official Name

Kulevanova, Svetlana

Main Affiliation

svku@ff.ukim.edu.mk

Now showing 1 - 10 of 34

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Consumer perception of risk-benefit of weight loss supplements and building safety
(Macedonian Pharmaceutical Association, 2020-10-29)
Zhivikj, Zoran
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Lonchar Velkova, Marijana
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Chemical characterization of Centaurium erythrea L. and its effects on carbohydrate and lipid metabolism in experimental diabetes
(Elsevier BV, 2014-02-27)
Stefkov, Gjoshe
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Dinevska-Kjovkarovska, Suzana
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Stanoeva, Jasmina Petreska
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Centaurium erythrea L. fam. Gentianaceae (CE) has been traditionally used for centuries in folk medicine of Balkans as a bitter medicinal herb for digestive complications and for treating febrile conditions and diabetes. The aim of this study was to gain insight into the chemical composition and underlying biochemical mechanism of action of the antihyperglycemic and antilipidemic activities of the dry extract of Centaurium erythrea L., wildly growing and traditionally used medicinal plant in the Republic of Macedonia.
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HPLC and UV-spectrophotometry analysis of flavonoids in spray-dried and freez-dried extracts of Teucrium polium L. (Lamiaceae)
(Macedonian Pharmaceutical Association, 2012-09)
Stefkov, Gjoshe
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Bankova, Vassya
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<jats:p>Тhe aim of the study was identification and determination of the content of flavonoids in dry extracts of Teucrium polium, collected from Republic of Macedonia. Two different drying procedures were used, freeze and spray draying. In freeze-dried (FDE) and spray-dried (SDE) extracts of aerial parts of T. polium five flavone aglycones (luteolin, apigenin, cirsiliol, cirsimaritin and cirsilineol) were identified by HPLC method, on the base of retention times and UV spectral data of the components of the extracts in comparison to the authentic samples of flavonoids. Additionally, seven glycosides of apigenin and luteolin were tentatively identified. No significant differences in the composition nor in the content of identified flavonoids were found between both extracts. The content of total flavonoids determined by UV-spectrophotometry with AlCl3 was 72.8 ± 0.62 mg Lut/g and 73.34 ± 0.53 mg Lut/g in FDE and SDE extract of T. polium, respectively.</jats:p>
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Flavonoids and Other Phenolic Compounds in Needles of Pinus peuce and Other Pine Species from the Macedonian Flora
(SAGE Publications, 2015-06)
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Stefkov, Gjose
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Stanoeva, Jasmina Petreska
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<jats:p> Flavonoids and other phenolic compounds in young needles of four pine species, Pinus peuce, P. nigra, P. mugo and P. sylvestris from the Macedonian flora were investigated. The amount of total phenols and total flavonoids were determined using Folin-Ciocalteau and aluminum chloride assay, respectively. The obtained results revealed that the total phenolic content (TPC) and total flavonoids content (TFC) varied among different pine species ranging from 9.8 to 14.0 mg GAE/g and from 3.3 to 7.2 mg CE/g of dried plant material, respectively. Qualitative analysis of flavonoids and other phenolic components was made by a LC-DAD/ESI-MS<jats:sup>n</jats:sup> optimized chromatographic method. A total of 17 phenolic components were identified and classified as: acids (2), procyanidins (2) and flavonoid glycosides (13). The most prevalent components were flavonoid glycosides, especially flavonols and methylated flavonols (9). Additionally, 3 components were found as acylated flavonol glycosides with ferulic and p-coumaric acid. The last one was found not only in esterified form but also in the free form. Only one flavone-apigenin glycoside was detected. Procyanidins were identified as catechin derivatives, both dimers and trimers. </jats:p>
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Comparative Study of Balkan Sideritis Species from Albania, Bulgaria and Macedonia
(Sciencedomain International, 2015-01-10)
Ibraliu, Alban
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Trendafilova, Antoaneta
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Anđelković, Boban
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Qazimi, Bujar
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Gođevac, Dejan
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Chemical composition and cytotoxic activity of Calendulae aetheroleum
(2023)
Davkova, Iskra
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Zhivikj, Zoran
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Petreska Ivanovska, Tanja
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Trajkovska, Ana
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Resource assessment and economic potential of bilberries (Vaccinium myrtillus and Vaccinium uliginosum) on Osogovo Mtn., R. Macedonia
(Elsevier BV, 2014-11)
Stefkov, Gjoshe
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Petreska Stanoeva, Jasmina
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Melovski, Ljupcho
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Chemical Characterization and Antioxidant Activity of Mountain Pine (Pinus mugo Turra, Pinaceae) from Republic of Macedonia
(ACG Publications, 2018-10-08)
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Stefkov, Gjoshe
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Karanfilova,, Ivana Cvetkovikj
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Panovska, Tatjana Kadifkova
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Stanoeva, Jasmina Petreska
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Differentiation of Cannabis seeds employing digital morphological screening and infrared spectroscopy coupled with multivariate modeling
(Elsevier, 2024-05-01)
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Trajkovska, Ana
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Cultivation of Cannabis for medicinal purposes primarily relies on seed propagation with expected variations in yield, cannabinoid content, growth rate and seed material non-uniformity. This study aims to employ digital methods for morphological analysis and infrared spectroscopy, combining them with multivariate analysis to characterize and differentiate Cannabis seeds. Morphological traits of 100 seeds from both commercial Cannabis specimens and wild-growing local varieties were analyzed using the high-throughput phenotyping software in addition to their collected infrared spectra in the mid-IR region. Subsequently, a chemometrics approach by means of Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), and Partial Least Square-Discriminatory Analysis (PLS-DA) was applied. The statistical indicators of the PLS-DA model (R2X=0.99, R2Y=0.63, Q2=0.64) demonstrate strong predictive capabilities for the differentiation of Cannabis seed specimens based on morphological attributes. The score scatter plot clearly shows a distinct grouping pattern, primarily driven by seed size. Wild-type seeds predominantly cluster into group 1, characterized by smaller diameters, while commercial seeds cluster into group 2. By analysing spectral data, in contrast to the expected differentiation based on secondary metabolites (cannabinoids) in the seeds, differentiation was based on the macronutrient profile with characteristic bands at 3275 cm−1, 2921 cm−1, 2852 cm−1, 1743 cm−1, 1630 cm−1, 1532 cm−1, 1459 cm−1, 1239 cm−1, 1157 cm−1, 1094 cm−1, 1018 cm−1, identified as the most distinctive spectral features. The PCA model (R2X=0.88 and Q2=0.85) was composed of 5 principal components explaining 88% of the spectral variations. The loading plot of the PLS-DA model reveals the distinctive spectral features for both groups (lipid and carbohydrate bands - group 2 samples, protein and water content - group 1 samples). The developed models have the potential for application for rapid screening of quality parameters of Cannabis seeds and their differentiation.
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Chemotaxonomic contribution to the Sideritis species dilemma on the Balkans
(Elsevier BV, 2015-08)
Stanoeva, Jasmina Petreska
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Stefkov, Gjose
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Alipieva, Kalina

Kulevanova, Svetlana

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