Pop gjorcheva, Daniela

Preferred name
Pop gjorcheva, Daniela
Official Name
Pop gjorcheva, Daniela
Main Affiliation
Email
dpopgjorcheva@medf.ukim.edu.mk

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    Thyrotoxicosis Associated with Cholestatic Jaundice Treated with Therapeutic Plasma Exchange–Case Report
    (OMICS Publishing Group, 2017)
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    Chalovska, Viktorija
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    Avramoski, Vladimir
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    Sentinel Lymph Node Detection in Colorectal Cancer - First Experience
    (ID-Design/Scientific foundation SPIROSKI, 2017-10-15)
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    Colorectal cancer (CRC) is the second commonest cancer in women, the third in men, being the fourth commonest cause of cancer death. The most important factor for prognosis and staging in CRC patients is the status of the regional lymph nodes (LN).
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    Gender differences in detecting coronary artery disease with dipyridamole stress myocardial perfusion imaging using 99m-Tc sestamibi gated SPECT
    (Macedonian Academy of Science and Art (MANU), 2005-08-26)
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    Peovska, Irena
    There are some specifics in the presentation of coronary artery disease (CAD) in women compared with men that may cause diagnostic pitfalls. The accuracy of noninvasive diagnostic testing in women tends to be lower than that in men. Stress myocardial perfusion imaging with 99m-Tc sestamibi gated SPECT is an accurate technique for detecting CAD. Only a few studies have compared dipyridamole stress imaging according to gender. The aim of the study was to compare the diagnostic value of dipyridamole myocardial perfusion imaging with 99m-Tc sestamibi gated SPECT in detecting CAD among patients of both sexes. We studied 62 consecutive patients (38 men, 24 women) using 99m-Tc sestamibi gated SPECT and dipyridamole stress to detect CAD. All the patients also underwent coronary angiography. Overall regional sensitivity was significantly lower in women compared with men (71.4% vs. 92.7%, p=0.039). There were no significant differences for detecting CAD in individual coronary arteries, although regional sensitivity in all three vascular territories was higher in men compared to women. The lowest sensitivity in women was found in the LAD territory (66.6%). Overall regional specificity in men and women was similar and did not reach statistical significance (88.7% vs. 94.7%). Significantly lower specificity in men was found only in the RCA territory (79.1%), compared with that in women (100%). Our results confirmed that there are certain gender differences in the diagnostic performance of dipyridamole stress myocardial perfusion imaging with 99-Tc sestamibi gated SPECT which are assigned to the characteristics of the female population. However, the diagnostic accuracy is also quite high in women, which makes this technique efficient enough in detecting CAD among this population.
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    Vesicoureteral Reflux Detected with (99m)Tc-DTPA Renal Scintigraphy during Evaluation of Renal Function
    (ID Design Press/Scienfitic Foundation SPIROSKI, 2016-03-15)
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    Radionuclide techniques, as direct radionuclide cystography and (99m)Tc-DMSA scintigraphy, have been used in evaluation of vesicoureteral reflux (VUR) and reflux nephropathy (RN) in children. Dynamic (99m)Tc-DTPA scintigraphy is reserved for evaluation of differential renal function and obstruction in children, where hydronephrosis is detected by ultrasonography (US) pre- or postnatally.
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    Sentinel Lymph Node Detection in Breast Cancer – First Experience
    (Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2015-05-01)
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    Antevski, Borce
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    <jats:title>Abstract</jats:title> <jats:p> Introduction: Breast cancer accouns for 22.9% of all cancers in women and 13.7% of cancer deaths. Positive axillary lymphnodes (ALN) predict the development of distant metastases. The status of the sentinel lymphnode (SLN) is crutial for the treatment selection. </jats:p> <jats:p>Aim: To determine the benefits of SLN detection in patients with breast cancer. Material and methodology: 38 female patients (pts), age 44 ± 12 years, with T1-2 N0 M0 breast cancer, without enlarged ALN on ultrasound (US), were included. SLN detection was performed using gamma camera and gamma detection probe after periareolar subcutaneous and/or peritumoral injection of (99m-Technetium-SENTISCINT). Blue dye was administered 20 min before the operation. SLN was extirpated and ex tempore histopathology was performed. </jats:p> <jats:p>Results: Ex tempore SLN evaluation was negative and the lymphatic pathways preserved in 28/38 (74%) pts. In 10/38 (26%) pts SLN was positive, followed by radical surgery. In 3/28 ex tempore negative patients, histopathological analysis showed metastatic involvement (false negative). In 3/10 ex tempore positive patients micro metastases 0,2-2 mm were detected. 12 pts had 2 SLN, 8/12 (66%) had negative and 4/12 (34%) had positive SLN. 3 pts had a rare double drainage to axilla and a. mammaria int. </jats:p> <jats:p>Conclusion: Our results confirm that SLN detection technique is non-invasive, safe and reliable and should be incorporated into the guidelines for breast cancer pts (T1-2 N0 M0). The most reliable option for colloid application is the combined technique of periareolar and peritumoral injection. Patients with drainage to a. mammaria interna should be selected for adjuvant protocols.</jats:p>
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    Myocardial perfusion in patients with systemic lupus erythematosus and low to intermediate risk for coronary artery disease, assessed with 99mtc mibi myocardial perfusion scintigraphy –case reports
    (2017-06)
    Sandevska, Emilija
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    Damjanovska Krstic, Ljubinka
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    Objective: Due to early and accelerated atherosclerosis, the patients with systemic lupus erythematosus (SLE), asymptomatic for coronary artery disease (CAD) are in particular risk of acute myocardial infarction (AMI). A diagnostic approach for their risk stratification is needed, followed with appropriate management and treatment. Material and Methods: We present three patents with SLE, from two patients cohorts (younger and older-age group), with SLE history for more than 7 years, with more active phase of disease (SLEDAI score 3-5) and atypical chest pain. With low to intermediate risk for CAD according to traditional risk factors for CAD, but with presence of SLE–related risk factors for atherosclerosis, they underwent 99mTc Myocardial perfusion scintigraphy (MPS) (at rest and stress, as one-day protocol) for evaluation of myocardial perfusion and left ventricular (LV) functional abnormalities. Visual and quantitative analysis of perfusion and functional tomoscintigrams detected the presence of one (in 2 patients) or two vessel’s stress-induced ischemia (in 1 patient), with mild to severe intensity and 10-27% extent of ischemic LV myocardial mass. Regions with the perfusion abnormalities were accompanied with wall motion abnormality during the stress study. The global LV functional parameters were normal in both studies (stress vs rest) with higher transient dilation parameter (TID) in one patient, indicating the presence of more profound perfusion abnormalities. Two patients were referred for angiography which in both cases showed no evidence of significant coronary artery stenosis of the major coronary arteries. Along with their higher levels of serum concentrations of endothelin (ET-1) and C-reactive protein (CRP) the myocardial perfusion abnormalities resemble microvascular functional affection. Conclusion: We emphasize the importance of identification of asymptomatic high CAD risk patients with SLE and CAD evaluation in this patients' cohort in order to prevent premature cardiac death. Determination of the clinical pretest probability for CAD and assessment of myocardial perfusion with non-invasive imaging technique such as 99mTc SPECT MIBI MPS may help in detecting the patients that should be subjected to coronary angiography. Even in the case of microvascular dysfunction, without significant obstruction of coronary vassels, prevention and/or treatment of CAD traditional risk factors and better control of the SLE disease can prevent or postpone the accelerated development of atherosclerosis and the decrease the risk of cardiovascular events.
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    Schoolchildren thyroid volume in North Macedonia: data from a national survey in an iodine-sufficient country
    (Springer Science and Business Media LLC, 2020-02-04)
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    Ittermann, T
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    North Macedonia is historically iodine deficient, but due to the longstanding and effective preventive measures, it has been considered iodine replete since 2003. The aim of the recent national survey was to re-evaluate iodine status and to measure thyroid volume (TVol) by ultrasound in schoolchildren as a representative of the general population.
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    Effective doses to family members of patients treated with radioiodine-131
    (IOP Publishing, 2011-09-23)
    Zdraveska Kocovska, M
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    Vaskova, O
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    THYROID FUNCTION TESTS DURING PREGNANCY: THE IMPORTANCE OF REFERENCE RANGE ESTABLISHMENT
    (Balkan Clinical Laboratory Federation, 2018-10)
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