Hasani Jusufi, Arzana

Preferred name
Hasani Jusufi, Arzana
Official Name
Hasani Jusufi, Arzana
Main Affiliation
Email
arzana.hasani@medf.ukim.edu.mk

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    Correlation Between Real-Time Shear Wave Elastography and Liver Serum Markers in Determining the Stage of Liver Fibrosis in Patients with Chronic Liver Diseases
    (Walter de Gruyter GmbH, 2024-11-01)
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    Introduction: Non-invasive methods aim to predict the stage of liver fibrosis in line with histological findings via biopsy. Shear wave elastography and serum markers are proven as accurate non-invasive methods for determining liver fibrosis as a modern non-invasive methods compared to liver biopsy in staging hepatic fibrosis. Aims: This study aims to determine the correlation between Shear Wave Elastography and indirect and direct serum markers of fibrosis when staging liver fibrosis. Material and methods: The study was conducted in the Clinic of Gastroenterohepatology, the Institute of Immunology and Human Genetics, and the Institute of Pathology between 2021 and 2023. The study comprises 70 patients with liver lesions, diagnosed based on clinical results, laboratory tests, and ultra-sound imaging. All patients underwent liver biopsy, classified according to Ishak and Metavir score as a reference method for diagnosing liver fibrosis. Real-time shear wave elastography was also performed as a non-invasive method and serum markers were checked for liver fibrosis. Findings: The statistical analysis indicated a positive correlation between the values of direct and indirect liver fibrosis markers and Shear Wave Elastography results. Conclusion: Our study has demonstrated that shear wave elastography has a significant positive correlation with biochemical markers of liver lesions and serum markers of liver fibrosis, whereas it has a negative correlation with platelets.
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    IMPLEMENTATION OF SHEAR WAVE ELASTOGRAPHY AS A NEWMETHOD IN THE CLINIC OF GASTROENTEROHEPATOLOGY – SKOPJE
    (SHMSHM/AAMD, 2022-04)
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    Bina, Arta
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    Adem, Xhem
    Despite the fact that liver biopsy is so far considered as “ a golden standard” when diagnosing diffuse liver diseases,recently it has been replaced by non-invasive methods, such as serum markers of liver fibrosis and elastography,due to smallest amount of complications risk, and the likelihood for larger liver surface analysis.Our study comprises 40 patients, with confirmed liver scarring, based on previous laboratory findings, clinicalfeatures, and abdominal ultrasound.Based on the etiology and the stage of scarring, patients have been divided into three groups: patients withsteatosis (alcoholic and non-alcoholic), patients with hepatitis, and patients with liver cirrhosis. Generally therehas been established a positive correlation between elastography values and corresponding liver disease, exceptfor small number of patients with more aggressive liver lesions than expected, resulting in higher elastographyvalues.
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    СЛУЧАЈ НА ГАСТРИЧЕН МЕТАСТАТСКИ МЕЛАНОМ 2 ГОДИНИ ПО ПОЧЕТНА ДИЈАГНОЗА НА КОЖЕН МЕЛАНОМ
    (SHMSHM/AAMD, 2021-04)
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    Меланомот е најчестиот карцином кој метастазира во гастроинтестиналниот тракт, сепак, метастазите во желудникот е ретка појава. Ние го претставуваме случајот на пациентка со повеќе коморбидитети, дијагностицирана а потоа оперирана од бенка во дел на левото рамо 2 години пред презентацијата на неспецифични гастроинтерстинални симптоми и редукција на крвната слика. На горно дигестивна ендоскопија најдени се нејасно ограничени полипозни формации со васкуларна структура, кои хистопатолошки се потврдени за метастатски меланом во желудникот. Често неспецифични гастроинтестинални симптоми се причина за одложување на дијагностицирање на овој вид тумор, или воопшто не се дијагностицира ниту по обдукција. Заради ова, секој неспецифичен гастроинтестинален симптом заслужува една горно дигестивна ендоскопија во најкраток временски период, со цел рано дијагностицирање, спречување на напредување на болеста а по можност и навреме преземање на соодветен третман.
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    The Role and Significance of Non-invasive Methods, with a Particular Focus on Shear Wave Elastography in Hepatic Fibrosis Staging
    (Scientific Foundation SPIROSKI, 2022-04-14)
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    Shear Wave Elastography (SWE) represents a new, non-invasive method, used in the diagnosis of diffuse liver diseases. The method has been widely used instead of liver biopsy - an invasive procedure with potential major risk complications. Compared to liver biopsy, SWE provides an examination of larger areas of the liver, thus providing better staging of hepatic fibrosis.  30 patients were included in the study on basis of previous clinical, biochemical, and ultrasound findings indicating a presence of a chronic liver lesion.  Patients were divided into three groups: 6 patients with steatosis, 13 patients with viral hepatitis, and 11 patients with liver cirrhosis. Liver damage biochemical markers, serum markers of liver fibrosis, and SWE were determined in all patients. Statistical analysis revealed a positive correlation between SWE results, and the values of biochemical markers of the hepatic lesion, as well as serum markers of liver fibrosis.