CHakar, LJupcho
Preferred name
CHakar, LJupcho
Official Name
CHakar, LJupcho
Main Affiliation
Email
ljupco.chakar@medf.ukim.edu.mk
20 results
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Item type:Publication, INFORMED CONSENT IN GENETIC REASEARCH(Macedonian Association of Anatomists and Morphologists, 2023); ; ; ; Recognizing the ethical, legal, and social implications (ELSI) of genetic testing becomes crucial for physicians in the face of complex medical issues, as they are increasingly expected to counsel their patients regarding the medical, psychological, and social responses arising from genetic information. Genetic medicine, with its extreme complexity and the potential repercussions on an individual's life, raises important questions in the ethical, deontological, and legal realms of medicine, playing a primary role in personalized medicine. The aim of this paper is to underscore the significance of informed consent and to provide insights into the ethical procedures associated with genetic testing. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, TIME-DEPENDENT EXPRESSION OF IL-1β mRNA - A PRELIMINARY STUDY FOR POSSIBLE WOUND AGE MARKER(Macedonian Association of Anatomists and Morphologists, 2023); ; ; ; Siamkouri, RosicaAccurate estimation of wound age is a very important task in forensic medicine field, because it can helps in reconstruction of crime scene. IL-1β is proinflamatory cytokine and plays a major role in wound healing process. The aim of the study is to develop a method for the reliable estimation of dermal injury age. In this study the expression of IL-1β mRNA was evaluated by real-time PCR at skin human wounds with different post-injuried period. We collected 27 human skin wound samples from forensic autopsy cases at our Institute. In our study were include samples from lacerations, incised wounds and stab wounds, with a known time of injury and death. Wound samples were divided into five groups: control group (n=5); first group consisted of cases with immediate death (n=7); second group consisted of cases with survival from 1 hour to 6 hours (n=5); the third group comprised cases with survival from 6 hours to 72 hours (n=3); the fourth group comprised cases with survival from 72 hours to 168 hours (n=7). In this study we detected increased expression levels of IL-1 β mRNA in the second group with survival time from 1 to 6 hours. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphology of microglia in cerebral contusions(Macedonian Association of Anatomists and Morphologists, 2015); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Siderophages as parametar determing age of cerebral contusions(Medical Faculty, Ss Cyril and Methodius University in Skopje, 2015); ; ; ; - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, An autopsy finding in mechanical ileus caused by ingestion of foreign body(Springer, 2018-08); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The impact of hyperkaliemia on death due to extensive trauma in limbs(Springer, 2017-09); ; ; ; Bituljanu, Natasha - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Forensic Comparative Analysis of Etiological Factors of Medical Malpractice(SHMSHM - AAMD, 2024-05-10); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ETIOLOGY OF SUDDEN CARDIAC DEATH IN FORENSIC MEDICAL PRACTICE AND SELECTION OF CASES FOR POST-MORTEM GENETIC TESTING –5 YEAR RETROSPECTIVE STUDY(Macedonian Association of Anatomists, 2023-05-10); ; ; ; Sudden cardiac death (SCD) is a term used to describe death in a person who has no previously diagnosed heart disease, or is not expected to die at that stage of the disease. SCD is considered a major health problem in the world, accounting for 15-20% of all deaths, and the mechanism of its occurrence includes the development of ventricular tachycardia, which progresses to ventricular fibrillation and finally asystole. SCD is generally seen in the older population; however, a significant mortality rate is also observed in young people with hereditary heart pathology. The use of substances that can have an effect on cardiac function is associated with many cases of SCD, so toxicological substances should always be considered by forensic doctors and screening tests should always be performed. The aim of this research is to analyze the causes of sudden cardiac death and to select cases in which post-mortem genetic testing is indicated. For this purpose, a review was made of the autopsies performed at the Institute of Forensic Medicine between 2018 and 2022, the biochemical and toxicological findings of the various causes of death were analyzed, and the cases where the exact cause of sudden cardiac death was not determined were also analyzed. In the analyzed period of 5 years, the cases with cardiomyopathy dominated, followed by coronary artery heart disease, and in 20 percent of the cases the exact cause of death was not determined. Men dominated with a percentage representation of 80%.