Makazlieva, Tanja
Preferred name
Makazlieva, Tanja
Official Name
Makazlieva, Tanja
Main Affiliation
Email
tmakazlieva@medf.ukim.edu.mk
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Item type:Publication, Sentinel lymph node status versus tumor characteristics, neutrophil to lymphocyte ratio, C-reactive protein levels and C-reactive protein to albumin ratio-prognostic factors for primary cutaneus melanoma(Springer Science and Business Media LLC, 2019-09-18); ; ; Aim/Introduction: The aim of this study was to identify tumor characteristics of primary malignant melanoma, neutrophil to lymphocyte ratio (NLR), C - reactive protein (CRP) levels and C - reactive protein to albumin ratio (CRP/Alb) predictive of sentinel lymph node (SLN) positive status and their impact on disease recurrence, melanoma specific survival (MSS), disease free survival (DFS) and overall survival (OS) period. Materials and Methods: 100 patients with primary malignant melanoma, clinically staged T1b/T2+ (1-4mm thick) N0, M0 underwent SLN detection procedure. Tumor characteristics, NLR, CRP levels and CRP/Alb ratio were analyzed in correlation with SLN status. The optimal cutoff values of NLR and CRP/Alb were determined by the receive operative characteristics (ROC) analysis. Univariate and multivariate Cox regression analyses, t - test for continuous or X2 test for categorical variables and Kaplan-Meier curve analyses were performed to assess factors predicting SLN positive status, regional recurrence rate, DFS, MSS and OS period. Results: We identified Breslow`s thickness (OR=1,51; 95% CI 1,02- 2,01; p=0,034), presence of ulceration (p=0,041), lymphocytic infiltration (OR=0,42; 95% CI 0,18-0,99; p=0,02), high mitotic rate (p=0,031), high Ki67 index (p<0,01), high NLR (HR=2,45; 95% CI 1,52-3,34; p<0,01), increased CRP levels (HR=1,53; 95% CI 1,33-1,75; p<0,001) and high CRP/Alb ratio (HR=2,01; 95% CI 1,15-3,52; p=0,016) as independent predictors of SLN positive status. SLN status was the strongest predictor (HR=0,241; 95% CI 0,45-1,01; p=0,04) of DFS, MSS and OS period. Conclusion: We confirmed Breslow’s thickness, presence of ulceration, lymphocytic infiltration extent, high mitotic rate, high Ki67 index, high NLR, increased CRP levels and high CRP/Alb ratio as factors predictive of SLN metastatic involvement. We also confirmed SLN status to be the most significant independent predictor of DFS, MSS, OS and risk of regional recurrence. Key words: neutrophil to lymphocyte ratio, c - reactive protein to albumin ratio, prognostic factors, melanoma, sentinel lymph node - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Demographic and Clinical Features of Thyroid Carcinomas in Republic of Macedonia (1999-2010)(ID Design 2012/Scienfitic Foundation SPIROSKI, 2017-12-15); ; ; ; Thyroid carcinomas (TC) are the most common endocrine malignancies. In some parts of the world, the incidence of TCs has increased over the past few decades, especially in females according to some studies. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Coexistence of Paget disease and lung cancer - importance of patient management(Discover STM Publishing Ltd., 2022); ; ; Background: The coexistence of metabolic bone disease, such as Paget disease (PD) and malignant tumor is frequently described in patients with breast, prostate, lung, lymphoproliferative, colorectal, and renal neoplasms. Indeed, when evaluating cancer patients, there may be diagnostic dilemma of interpreting some changes in bone involvement, whether they are malignant or metabolic changes, since some radiological features of metabolic bone disease can mimic those of bone metastases. Case Presentation: We report a case of 55-year-old male patient, with diagnosed lung adenocarcinoma, referred to the Nuclear Medicine Department for a bone scintigraphy (BS), for evaluation of presented bone metastasis. The Single photon emission computed tomography (SPECT)/computer tomography (CT) scan revealed intensive metabolic accumulation of the radiotracer in cervical vertebra C7, and thoracic vertebra Th1, Th6, Th11, Th12, as well as lumbar vertebra L4, L5, left sacroiliac joint, both iliac and pubic bones and left proximal femur. The FDG PET/CT showed diffuse, but mildly increased uptake in Тh6, Тh11, L4, L5 and pelvic bones (SUV max = 3.3). The CT revealed destruction of Th11 body with compression fracture. Diagnosis of PD was made based on the findings of BS and PET/CT and further confirmed on bone biopsy and the patient was started with bisphosphonate therapy. Conclusion: BS and SPECT/CT are of great importance in accurate detection of incidental PD in patients with lung cancer. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Current State of Nuclear Nephrology in Modern Medicine(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-12-01); ; ; ; Poposka, DanielaGlomerular filtration rate (GFR) is the most reliable parameter of renal function. Regarding the complexity of the gold standard inulin clearance, different estimating equations have been developed with CKD-EPI creatinine equation recommended as the most reliable one. In some clinical situations where creatinine based equations might not be valid, alternative methods are needed. Nuclear medicine methods for measuring GFR with 51Cr EDTA and 99mTc DTPA have been widely used for decades. There are different methodologies for the measurement of kidney function with radiopharmaceuticals: urinary clearance, plasma clearance, multiple plasma sampling, slope intercept, single sample plasma equation, slope only, and the gamma camera-based method. Greater precision of measuring GFR is needed in certain clinical situations. The most common are diagnosis and follow up of chronic kidney disease and definition of the beginning of replacement therapy. The assessment of renal function is also important for potential kidney donors. In recent years, with the introduction of new chemotherapeutic drugs and targeted therapy, oncologic patients treated with nephrotoxic drugs have become more commonly referred for measuring GFR. The monitoring of renal function is important during treatment in order to detect the transformation from reversible acute kidney injury to irreversible chronic kidney disease as well as in the cases of renal insufficiency reduce the dosage and prevent accumulation of the drug and avoid dosage related toxic effects. Assessment of kidney function using measured mGFR will be an important milestone in the creation of more accurate and expanding personalized medicine principle in current onconephrology practice. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Prognostic factors in thyroid carcinomas: a 17-year outcome study(Archives of Endocrinology and Metabolism, 2019-09-30); ; ; ; The aim of our study was to evaluate the survival rate of all thyroid carcinomas (TCs) diagnosed in the 1999-2015 period in the Republic of North Macedonia and to analyze the prognostic influence of several characteristics on development of distant metastases, as well as to analyze the prognostic effect of seven clinical and constitutional features on mortality. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Nuclear medicine hybrid imaging (SPECT/CT) in distinguishing the presence of a hepatic hemangioma: Single center study(Centre for Evaluation in Education and Science (CEON/CEES), 2023); ; ; <jats:p>Objective. Hepatic hemangioma (HH) is the most common benign liver tumor, and the second most frequent tumor in the liver after hepatic metastasis. The SPECT/CT hybrid technique will be beneficial for the investigation of this type of HH since it can precisely identify the hepatic lesions. The aim of this study was to reevaluate the sensitivity and specificity of the nuclear medicine method for confirmation or exclusion of benign hemangioma of the liver based on a series of cases at our department and briefly review the literature. Methods. We retrospectively analyzed 107 patients, 62 females (57.94%) and 45 males (42.05%) with mean age 50.05±11.92 years, referred to the Nuclear Medicine Department for 99mTc-RBC scintigraphy of the liver to conclude or exclude the presence of HH, in the period 2019 to 2020. Results. Hepatic scintigraphy located the hemangiomas mostly in the right hepatic lobe. The size of the lesion varied from to 6-140 mm (46.04 ± 27.1); 13 hemangiomas were described as giant. SPECT-CT confirmed HH in 1 patient that was negative on ultrasound, besides 30/87 (34.48%) patients who were described as positive on US and turned out to be negative on the scintigraphic method. In 53 (60.92%) patients, positive matching of the US images and hybrid SPECT/CT imaging for HH was found. Most of the patients had benign referral diagnosis, while 12 of them had confirmed malignant diagnosis in whom eight (n=8, 66.67%) were confirmed free of hepatic metastasis and SPECT-CT detected HH, while in 4 patients who were described as positive for HH on the CT scan, the scintigraphic method excluded HH and further evaluation of the hepatic lesion was needed. Conclusion. Hepatic hemangiomas require a careful diagnosis to differentiate from other focal hepatic lesions, cooccurring diagnoses are also possible. Differentiating between HH and hepatic metastatic disease is a typical clinical difficulty when the problem is present in staging or monitoring patients with oncological disease.</jats:p> - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, The Contribution of SPECT/CT Bone Scintigraphy in the Localization of an Infective (Purulent) Sacroiliitis – A Case Report(ID Design 2012/DOOEL Skopje, 2020-09-03); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, What is in a name and what is in the brain? -clinicians’ dilemmas in the biomarker era(Elsevier BV, 2025-05); ; This viewpoint draws analogy from Shakespeare’s query, "What’s in a name?" and explores what defines neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD) and what clinicians understand by that name in relation to the underlying brain pathology and disease biology. The inspiration comes from the latest biological definitions of PD revealing significant similarities with the biological definition of AD.