Kocheva, Svetlana
Preferred name
Kocheva, Svetlana
Official Name
Kocheva, Svetlana
Main Affiliation
Email
svetlana.kocheva@medf.ukim.edu.mk
11 results
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Item type:Publication, Улогата на проточно цитометриската имунофенотипизација во дијагнозата и следењето на акутните леукемии во детска возраст(Лекарска комора на Македонија, 2014); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Procalcitonin-early biochemical marker for diagnosis, prognosis and treatment of sepsis in neonates and oncological patients with febile neutropenia(Macedonian Association of Anatomists, 2020); ; ; Kimovska Hristova, MicaPediatric sepsis is a life - threatening condition, in which the immune system, instead of controlling the infection,causes damage to tissues and organs. The aim of this study was to determine the role of procalcitonin (PCT)in the early diagnosis of sepsis in high - risk infants and Oncological patients with febrile neutropenia,its prognostic value,and the role of PCT in the cho ice of antibiotic. The study is designed as retrospective - prospective, it is being worked at the PHI UC for Children Diseases Skopje. I t includes 60 critical newborns and 40 O ncology patients.The examined group were divided into two subgroups:30 critical i nfants with bacterial sepsis in the intensive care unit and 20 O ncological patients with sepsis and febrile neutropenia. PCT was determined the first 24h,3 - 5 days and 6 - 14 days of hospitalization. The value of PCT during the first 24 hours of admission was increased in all 50 patients .Most of them had signs of severe sepsis and few od them had signs of septic shock . In all of them, double parenteral antibiotic therapy was started .Seven patients has died in the first five days. After 3 - 5 days of the start of antibiotic therapy, PC T values decreased . After the third measurement, PCT values continued to decrease and in majority of the patients the antibiotic therapy was discontinued. By measuring the values of PCT, an early diagnosis of sepsis can be made. This is important to start with antibiotics to prevent sepsis and septic shock . T he dynamic in the values of PCT determine the duration of antibiotic,its modification,the rational uses of antibiotics and the emergence of resistance to it. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, T-lymphoblastic leukemia/lymphoma in macedonian patients with Nijmegen breakage syndrome(Walter de Gruyter GmbH, 2016-07-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, First Cases of Hb Agrinio Described in Patients from the Republic of Macedonia(Taylor & Francis Online, 2017-12-08); ; Previous molecular analyses of α-thalassemia (α-thal) in the Republic of Macedonia have identified the following genetic defects: –α3.7 (rightward), –(α)20.5 and – –MED I deletions and Hb Icaria [α142, Term→Lys (α2), HBA2: c.427T>A] and polyadenylation signal (polyA) [AATAAA>AATGAA (α2), HBA2: c.*92A>G] point mutations. Here, we report two unrelated patients from the Romani population in the Republic of Macedonia, homozygotes for the α2-globin gene variant Hb Agrinio [α29(B10)Leu→Pro; HBA2: c.89T>C]. To date, Hb Agrinio has been described only in individuals of Greek, Cypriot and Spanish origin. Both of our patients had early presentation of the disease (3.5 years and 2 months, respectively) with frequent blood transfusions from early infancy. They have a severe intermediate phenotype of thalassemia (Hb H disease) with hemoglobin (Hb) levels of 7.8 and 7.7 g/dL, respectively. Although the HBA2: c.89T>C mutation results in an α+ allele, the severe phenotype of the homozygotes is due to the production of hyperunstable α chains that undergo post translational precipitation. This leads to a greater degree of red cell damage and hemolytic anemia. The detection of Hb Agrinio in two unrelated families of Romani ethnic origin, may suggest it is a founder mutation in this population living in the Republic of Macedonia. Considering the severity of the clinical presentation of the homozygotes or compound heterozygotes for this rare Hb variant, a targeted molecular screening for Hb Agrinio mutation carriers should be considered in all patients of Romani ethnic origin with manifested microcytosis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Chelation therapy in thalassemia major: Why and when(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2015); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical characteristics and threatment resulats of childhood acute lymphoblasic leukemia in North Macedonia(Macedonian Academy of Sciences and Arts / Sciendo, 2020); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A Novel Approach for Modelling the Relationship between Blood Pressure and ECG by using Time-series Feature Extraction(SCITEPRESS - Science and Technology Publications, 2020); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Demographic, Clinical and Biochemical Characteristics of Pediatric Obesity: Interim Analysis of a Larger Prospective Study(Medical University of Plovdiv, 2020-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pediatric in situ lymphoma and Castleman disease – possibility for progression or presence of synchronous diseases(EUROPEAN ASSOCIATION FOR HAEMATOPATHOLOGY, 2024-09); ; Jovanovska, AleksandraA child, 7.5 years old with a history of previously diagnosed Pediatric In Situ Folicullar Lymphoma, treated by ‘watch and wait’ strategy has been admitted at the Pediatric University Clinic, Skopje, in February 2023. In June 2022, due to worsened generalised lymphadenopathy (No.1206640) and symptoms of anaemia, thrombocytopenia and slight splenomegaly, new lymph node biopsy has been done.. The obtained diagnosis was Atypical Lymphoid Hyperplasia. In February 2023, the child was again admitted to the hospital with signs of coughing and dyspnea. On physical examination there were found increased cervical lymph nodes and metabolic disease in the mediastinal and abdominal lymph nodes as well as in the spleen and lung parenchyma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Autoimmune lymphoproliferative syndrome identified through reverse phenotyping.(Cent Eur J Immunol 2022; 47 (2): 179-182, 2022-07-15); ; Antevska-Trajkova ZAutoimmune lymphoproliferative syndrome (ALPS) is a chronic non-malignant lymphoproliferative disorder caused by mutations in the genes involved in programmed cell death. It is inherited as an autosomal dominant pattern with variable penetrance. In this paper we present the first report of a Macedonian family with ALPS, caused by a novel heterozygous variant in the FAS gene. The next generation sequencing (NGS) analysis in a patient with splenomegaly, suspected for hereditary spherocytosis, showed presence of the FAS c.913dupA, p.Thr305AsnfsTer16 variant. The same variant was present in the patient’s mother, but not in the mother’s parents (proband’s grandparents). Thus, the pathogenic FAS variant has arisen as a de novo event in the proband’s mother. Later, analysis of the newborn affected sister showed presence of the same FAS variant. Additional clinical and laboratory investigations in the proband and her sister confirmed the presence of specific biomarkers for ALPS. A first-line NGS analysis allows identification of the genetic defect and initiation of appropriate clinical examinations to promptly establish the clinical diagnosis in patients with rare diseases. Reverse phenotyping in our case provided a prompt and accurate diagnosis and early initiation of specific therapy.