Ristova, Mimoza

Preferred name

Ristova, Mimoza

Official Name

Ristova, Mimoza

Main Affiliation

mristova@pmf.ukim.mk

Now showing 1 - 10 of 12

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Variation of indoor radon concentration and ambient dose equivalent rate in different outdoor and indoor environments
(Springer Nature, 2016-05)
Stojanovska, Zdenka
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Boev, Blazo
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Zunic, Zora S
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Ivanova, Kremena
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Subject of this study is an investigation of the variations of indoor radon concentration and ambient dose equivalent rate in outdoor and indoor environments of 40 dwellings, 31 elementary schools and five kindergartens. The buildings are located in three municipalities of two, geologically different, areas of the Republic of Macedonia. Indoor radon concentrations were measured by nuclear track detectors, deployed in the most occupied room of the building, between June 2013 and May 2014. During the deploying campaign, indoor and outdoor ambient dose equivalent rates were measured simultaneously at the same location. It appeared that the measured values varied from 22 to 990 Bq/m(3) for indoor radon concentrations, from 50 to 195 nSv/h for outdoor ambient dose equivalent rates, and from 38 to 184 nSv/h for indoor ambient dose equivalent rates. The geometric mean value of indoor to outdoor ambient dose equivalent rates was found to be 0.88, i.e. the outdoor ambient dose equivalent rates were on average higher than the indoor ambient dose equivalent rates. All measured can reasonably well be described by log-normal distributions. A detailed statistical analysis of factors which influence the measured quantities is reported.
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Availability of technology for managing cancer patients in the Southeast European (SEE) region
(Elsevier BV, 2022-03)
Dosanjh, Manjit
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Georgieva, Petya
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Balin Kovacevic, Marijana
Background: The Southeast European (SEE) region of 10 countries and about 43 million people differs from Western Europe in that most SEE countries lack active cancer registries and have fewer diagnostic imaging devices and radiotherapy (RT) units. The main objective of this research is to initiate a common platform for gathering SEE regional cancer data from the ground up to help these countries develop common cancer management strategies. Methods: To obtain detailed on-the-ground information, we developed separate questionnaires for two SEE groups: a) ONCO - oncologists regarding cancer treatment modalities and the availability of diagnostic imaging and radiotherapy equipment; and b) REG - national radiation protection and safety regulatory bodies regarding diagnostic imaging and radiotherapy equipment in SEE facilities. Results: Based on responses from 13/17 ONCO participants (at least one from each country) and from 9/10 REG participants (all countries but Albania), cancer incidence rates are higher in those SEE countries that have greater access to diagnostic imaging equipment while cancer mortality-to-incidence (MIR) ratios are higher in countries that lack radiotherapy equipment. Conclusion: By combining unique SEE region information with data available from major global databases, we demonstrated that the availability of diagnostic imaging and radiotherapy equipment in the SEE countries is related to their economic development. While immediate diagnostic imaging and radiation therapy capacity building is necessary, it is also essential to develop both national and SEE-regional cancer registries in order to understand the heterogeneity of each country’s needs and to establish regional collaborative strategies for combating cancer.
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DATASET/RAW DATA for manuscript titled "ESTABLISHING DIAGNOSTIC REFERENCE LEVELS IN DIGITAL MAMMOGRAPHY UNITS IN THE REPUBLIC OF NORTH MACEDONIA"
(2025-01-13)
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Mirjeta Mediji Arifi
The main objective of this study is to evaluate radiation exposure and establish a baseline for Diagnostic Reference Levels in digital mammography using the diagnostic and screening examination data from eight state-managed mammography imaging centres/units in the Republic of North Macedonia. Mean Glandular Dose (MGD) was studied from about 30000 images from about 8000 studied cases by digital mammography. Several factors and parameters were considered, such as anode/filter combination, left and right breast in two projections each (craniocaudal (CC), mediolateral oblique (MLO)), compressed breast thickness (CBT), the X-ray tube voltage in kVp, X-ray tube current-time product in mAs, and the compression force. The overall MGD for all examinations subject to this study obtained from CC and MLO projections from both breasts were evaluated to be 1.34 mGy and 1.61 mGy, respectively. Median MGDs, minimum, and maximum, were calculated to be 1.15 mGy, 0.1 mGy, and 9.93 mGy, respectively. The 75th percentile of the MGD for CC acquisitions increased from 0.94 mGy to 3.67 mGy with the increase of the CBT from 0 to 120 mm (step 10 mm). Likewise, the 75th percentile of MGD for MLO acquisitions, increased from from 0.44 mGy to 4.91 mGy, depending on the CBT. The obtained figures of MGD versus CBT for breast thicknesses between 30 and 75 mm for the eight mammography units were compared with the Acceptable European (ACC), Achievable European (ACH), Belgian diagnostic reference levels and MGDs reported for other countries/regions. The results showed that the mean MGD values of seven of the eight Mammography units examined in total appear to be lower than those of ACC, ACH, and Belgian reference values. Only the MGD calculated for one of the eight examined units appeared higher than the ACC.
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Dental cementum examination with SEM/EDX for unravelling details along the lifeline to assist identification of a female individual
(Elsevier BV, 2021-11)
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Josheva, Dijana
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Brozek-Mucha, Zuzana
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Simulations of photon versus particle therapy for treating cancer in canines using matrad: case study of a beagle with pituitary macroadenoma
(Faculty of Veterinary Medicine, University of Belgrade, Serbia, 2025)
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Gjoreska, Andrijana
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Simonovska, Marija
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In this study, we propose that dogs diagnosed with tumors exhibiting a similar pathology to those in humans could play a crucial role in trials for novel radiation therapy modalities, such as particle therapy (beyond protons and carbon ions) or FLASH therapy. A multidisciplinary team including a veterinary oncology scientist, a human radiation oncologist, and medical physicists, conducted a simulation of a comparative treatment planning using matRad software to compare the benefits of three treatment modalities: (1) X-rays, (2) protons, and (3) carbon ions. Diagnostic results from a Beagle dog with a pituitary macroadenoma were utilized for this study. The dog was euthanized due to severe deterioration in basic physiological functions, including eating, swallowing, breathing, head tilt, and movement, over a period of several days. The dog’s owner, who is closely related to one of the coauthors, provided oral consent for the use of all available clinical data from the deceased dog. These results were used as a hypothetical case to simulate and compare the effectiveness of three radiation treatment modalities. This pioneering approach opens an avenue to the potential of involving living companion animals already diagnosed with cancer in treatment research, advancing both veterinary and human oncology. The results suggested that if treated with radiation, the dog would have benefited most from particle therapy, which delivers a maximum dose to the tumor while considerably minimizing exposure of the surrounding critical organs – an advantage not achieved with conventional X-rays. This collaboration emphasizes the importance of integrating veterinary and human radiation oncology. This work paves the way for developing initial protocols to treat pets with cancer, serving as a preclinical foundation before clinical studies are conducted on humans.
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Introduction of IMRT in Macedonia: Optimizing the MLC parameters
(Institute of Physics, Faculty of Natural Sciences and Mathematics, "Ss. Cyril and Methodius University", Skopje, Macedonia, 2012)
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Intensity modulated radiotherapy (IMRT) for the Varian Eclipse Treatment Planning System (TPS) requires optimization of the values of two parameters of the Multi Leaf Collimator (MLC) – the transmission of the MLC and the so called Dosimetric Leaf Gap (DLG). This paper describes the optimization of those parameters for one of the linear accelerators at the University Clinic for Radiotherapy and Oncology in Skopje. The starting values for the MLC parameters were determined by dose measurements with ionization chambers. Those measured values were introduced in the TPS and an IMRT test plan was created. The acquired test plan was used for irradiation of the two-dimensional chamber array “MatriXX”, and for comparison of the measured results with the corresponding results calculated by the TPS. By iteratively changing the two MLC parameters we optimized their values, so that the calculation corresponds to the measurement as much as possible. The final results of the optimization were introduced in the TPS thus enabling calculation of IMRT plans and proceed towards the phase of clinical introduction of this radiotherapy technique.
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Formation of WO3 thin films from RF sputtered tungsten films by air annealing: A cost-effective approach
(National Library of Serbia, 2025)
Jovanovski, Stefan
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Popovic, Maja
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Novakovic, Mirjana
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Rajic, Vladimir
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WO3 thin films were prepared by RF sputtering metallic tungsten onto glass substrates, followed by thermal oxidation through annealing in air. This technique is straightforward, cost-efficient, and time-effective, achieving high deposition rates of 16 nm/min on average at 200 W magnetron power for the highly homogeneous W-metallic films. SEM/EDX analysis showed that after annealing at 450ᵒC in air, the RF sputtered 269 nm thick metallic W films with a round grain morphology (~30 nm) turned into 420 nm thick nearly stoichiometric transparent WO3 (tungsten (VI) oxide) film, with a dramatically changed morphology of aggregated crystal rods approximately 1 μm long. XRD and Raman spectroscopy confirmed a biphasic crystal structure, with a dominant monoclinic phase and a minor tetragonal phase. XPS analysis revealed the characteristic W4f7/2 and W4f5/2 electron peaks associated with the W6+ oxidation state, with no evidence of W5+ species, indicating a stoichiometric nature of the WO3 films.
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Establishing Diagnostic Reference Levels in Digital Mammography from Eight Mammography Units Using over 30,000 Images
(MDPI AG, 2025-03-10)
Mediji-Arifi, Mirjeta
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Introduction: Diagnostic reference levels (DRLs) in digital mammography were determined from 31,040 digital mammography images acquired from diagnostic and screening examination data from eight state-managed mammography centers/units in the Republic of North Macedonia (RM). The main objective is to establish a diagnostic reference level for mammography examinations at different ranges of breast thickness. Materials and methods: Approximately 30,000 mammography images were used to evaluate mean glandular dose (MGD) and compressed breast thickness (CBT) for each projection, craniocaudal (CC) and mediolateral oblique (MLO). The stratified DRL was derived by calculating the 75th percentile of the MGD across all the samples at various CBT ranges for both projections. Results and Discussion: The overall median MGDs, minimum, and maximum were calculated to be 1.15 mGy, 0.1 mGy, and 9.93 mGy, respectively. As the CBT increased from 7 to 120 mm, the 75th percentile of the MGD increased from 0.94 mGy to 3.67 mGy for CC, and from 0.44 mGy to 4.91 mGy for MLO projections. Conclusions: The study established local DRLs for the digital mammography systems at the 75th percentile, which compared well with the values reported for other countries/regions. The DRL defined per CC and MLO image view for a specific CBT indicated that at least one mammography facility needs optimization.
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Breast Glandularity Distribution and Refining the Mean Glandular Dose Estimates in Digital Mammography
(Ovid Technologies (Wolters Kluwer Health), 2025-10)
Arifi, Mirjeta Mediji
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Background: In mammography, radiation dose is typically expressed as the mean glandular dose (MGD), which represents the dose delivered to the glandular tissue of the breast. Materials and Methods: This study compares MGD estimates obtained using three different methodologies: (I) MGD-Dance-Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) – Calculated manually for each patient using Dance’s formula, incorporating mammographic breast density values derived from the LIBRA application, thereby replacing Dance’s standard glandularity assumption with image-specific values; (II) MGD-Dance – Calculated using Dance’s formula with the conventional assumption of 50% glandularity; (III) MGD-Displayed – Extracted directly from the Digital Imaging and Communication in Medicine header of each mammogram. Results: A total of 688 anonymized mammograms from 172 women undergoing routine screening were analyzed, with complete technical and patient-related data. The mean MGD values obtained by the three methods were: MGD-Dance-LIBRA: 2.97 mGy; MGD-Dance: 2.78 mGy; and MGD-Displayed: 2.81 mGy. The average glandularity across the dataset was estimated at 14%. A strong correlation was observed between MGD-Dance and MGD-Dance-LIBRA values (R² =0.9865). The refined dose estimation using image-specific glandularity from LIBRA consistently produced slightly higher values compared to the standard Dance method, highlighting the impact of the commonly assumed 50% glandularity, which overestimates the true average density. Conclusions: Incorporating individualized breast density estimates from the LIBRA application into Dance’s formula provides a more refined and accurate method for calculating MGD in digital mammography.
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Preparation of CuWO4 films by thermal annealing of simultaneously RF/DC magnetron co-sputtered Cu–W films
(Elsevier BV, 2025-10)
Jovanovski, Stefan
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Popović, Maja
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Novaković, Mirjana
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Jugović, Dragana
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Gloginjić, Marko

Ristova, Mimoza

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