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    Outcomes of surgically treated distal radius fractures associated with triangular fibrocartilage complex injury
    (Elsevier B.V., 2020-09)
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    Study design: Prospective cohort. Introduction: Clinical studies that evaluate the correlation between associated lesions of the triangular fibrocartilage complex (TFCC) and outcome of distal radius fractures expressed with the patient-rated disability are missing. The purpose of this study was to evaluate the outcomes of distal radius fractures associated with or without an injury of the TFCC. Methods: Patients undergoing operative treatment for distal radius fracture were prospectively enrolled (n = 70). TFCC was examined by wrist arthroscopy and injuries classified according to Palmer. Comparative analyses were performed on 45 patients with TFCC injury (injured group) and 25 patients with intact TFCC (intact group). The outcome measures included the Patient-Rated Wrist Evaluation (PRWE) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaires, 3 and 12 months after injury. Results: TFCC was injured in 45 patients (64%). In patients with intact TFCC, mean total PRWE score was 27 (3 months) and 16 (12 months), compared to patients with TFCC injury with 40 (at 3 months) and 24 (at 12 months). Mean DASH scores were 26 and 13 at 3 and 12 months for the intact group and 39 and 27 for the injured group. PRWE and DASH results showed significant difference at 3 and 12 months when compared with Mann-Whitney test. Discussion: PRWE and DASH scores evaluation showed that patients with associated TFCC injury had greater pain and disability at 3 and 12 months after injury. Conclusions: Disability outcomes were worse in patients with distal radius fracture, where TFCC was injured. TFCC injuries are an important cofactor affecting the outcome of distal radius fractures.
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    Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
    (Taylor & Francis Online, 2021-12)
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    COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients.
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    Identification of risk factors for lethal outcome in patients with severe community-acquired pneumonia
    (Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2020)
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    Denkovska E
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    Aim of the study. To determine clinical and biochemical parameters as risk factors for mortality in patients with severe community-acquired pneumonia. Material and methods. A prospective, parallel group analysis of patients with community-acquired pneumonia, treated at the Intensive Care Unit of the University Clinic for Infectious Diseases in period of one year. A total of 42 adults (>=18 years) were enrolled, who were divides in two groups according to the outcome; survived and deceased. The outcome was defined as survival or death during the 30-day hospital treatment. Demographic, clinical as well as laboratory parameters were evaluated in all patients on admission. A statistically significant finding was considered if p<0,05. Results: The average age of patients was 61+15.2 years, and 33 (78.6%) were males. The overall mortality was 50%. In 29 (69%) patients a comorbid condition was registered, and comorbidity showed a statistical significance regarding the outcome. All had tachycardia, tachypnea and hypotension on admission, but impaired consciousnesses and shock were associated with mortality. Patients who died had a higher leukocyte count (15.9+11.8x109/L), higher procalcitonin levels (43.9+77.3 mg/ml), higher serum glucose levels (11.4+6.2 mmol/L) and lower PaO2/Fi O2 (122.64+ 52.8). Hyperglycaemia and hypoxia were the biochemical parameters that showed a statistically significant difference between the two study groups. Conclusion: Early identification of the risk factors for lethal outcome in patients with severe community acquired pneumonia enables implementation of adequate therapeutic measures, thereby decreasing the mortality in this group of critically ill patients.
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    Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
    (Elsevier Ltd., 2022-11-05)
    NIHR Global Health Unit on Global Surgery
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    COVIDSurg Collaborative
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    Konjanoska, Maja
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    Kavain, Snezhana B.
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    The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
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    Upper Extremity Nerve Compression Syndromes – More Than Just a Carpal Tunnel Syndrome: A Review Article
    (Scientific Foundation SPIROSKI, Skopje, Republic of North Macedonia, 2025-05-10)
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    BACKGROUND: Besides carpal tunnel syndrome and cubital tunnel syndrome, other nerve entrapment sites in the upper extremity are less recognized. Only half of the upper extremity compression neuropathy syndromes are actually carpal tunnel and cubital tunnel compressions. This suggests that the rest of the entrapment syndromes are potentially not treated adequately. They are often misdiagnosed or the level of compression is not being distinguished. AIM: To raise awareness of compression syndromes (other than the carpal tunnel) in the arms and to describe the clinical triad to diagnose them. METHODS: This is a narrative review of the clinical features of the compression syndromes of the median, ulnar, and radial nerves in the upper extremities. The diagnostic triad for each syndrome is analyzed. The review focuses especially on the lacertus syndrome and describes the surgical release. CONCLUSION: A correct diagnosis is essential for targeted treatment of upper extremity nerve compression syndromes. It should also include an assessment of individual muscle strength, which is a critical part of the clinical neurological tests.
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    Outcome Evaluation of Arthroscopic Resection of Dorsal Wrist Ganglia
    (Macedonian Academy of Sciences and Arts, 2023)
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    Goals: Arthroscopic ganglionectomy has become an increasingly popular surgical option for dorsal wrist ganglia. The aim of this study was to describe our technique for the arthroscopic treatment of dorsal wrist ganglia and to evaluate the clinical results as well as the recurrence rate in our patients. Methods: In a prospective study, 48 patients who underwent arthroscopic treatment of dorsal ganglion of the wrist were included. Patients were evaluated preoperatively and 3 and 24 months post arthroscopy. A presence of recurrence at 24 months was recorded. The subjective outcome was evaluated with The Patient-Rated Wrist Evaluation (PRWE) and the Visual analog scale (VAS). Objective outcomes included grip strength and range of movement measurements. Results: The mean age was 36 years; the majority were women (36/48). Mean grip strength and the average flexion and extension in the wrist showed improvement after 3 months. The total PRWE score improved from 26.7 preoperatively to 10.2 at three months and 2.4 two years after surgery. After 24 months follow-up, there were only two patients with recurrence (4.2%). Conclusion: The arthroscopic resection of the dorsal wrist ganglia is a procedure with a low recurrence rate and lowest scaring and stiffness; it should be considered as a golden standard for operative treatment of the dorsal wrist ganglia.
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    Assessment of Severity Scoring Indexes in mortality prediction of Severe Community Acquired Pneumonia
    (2022-11)
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    Rangelov Goran
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    Introduction: community acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Approximately 8-36% require treatment in the intensive care unit (ICU) due to disease severity. Aim of the study: to asses the capacity of severity scoring indexes to predict the mortality of severe CAP. Methods: the study included 129 adult patients with CAP hospitalized at ICU of the University Clinic for Infectious Diseases in Skopje during a 3-year period. Primary outcome variable was 30-day in-hospital mortality. Demographic, clinical and biochemical parameters were recorded and seven severity scores were calculated: Charlson comorbidity Index, CURB 65, SCAP at admission, SAPS II and APACHE II after 24 hours, MPM and SOFA score during the first 48 hours. Receiver Operating Curve (ROC) analysis was performed and areas under the curve (AUC) were calculated for all analyzed severity indexes to evaluate their capacities to predict the mortality. Results: the mean age of studied patients was 61 year and 66,7% were males. An overall mortality was 43.4%. Charlson Comorbidity Index has higher value in non-survivors and it was associated with a poor outcome. All scores had significantly increased values among non-survivors, except CURB-65 that had similar results in both groups, with no statistical significance with the outcome. AUC for all scores had close values, ranging from 0.714 for APACHE II to 0.755 for SCAP. The highest AUC showed MPM and SOFA score when calculated at 48 hour after the admission, with values of 0.800 and 0.839 respectively. Conclusion: according to the results of our study, the most commonly used severity scoring indexes had strong ability to detect patients with pneumonia that had increased risk for poor outcome, but none of them showed to be superior over the others in pneumonia mortality prediction.