Kakasheva-mazhenkovska, Lena
Preferred name
Kakasheva-mazhenkovska, Lena
Official Name
Kakasheva-mazhenkovska, Lena
Main Affiliation
Email
lena.kakasheva@medf.ukim.edu.mk
12 results
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Item type:Publication, MORPHO-HISTOLOGICAL CHARACTERISTICS OF BRUISES WITH DIFFERENT AGE -qualitative study(Macedonian Association of Anatomists, 2022); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of sperm quality in young men in North Macedonia(Институт за јавно здравје на Република Македонија = Institute of public health of Republic of Macedonia, 2023); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MORPHOHISTOLOGICAL CHARACTERISTICS OF BRUISES WITH DIFFERENT AGE-QUANTITATIVE STUDY(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2022); ; ; Bruises as common skin lesions are important in forensic expert reports in determining the time of death in many cases of domestic violence or child abuse. The aim of this study was to present the differences between bruises with different time of origin by evaluation of their histological characteristics.The study included 60 human skin samples divided into control andexperimental groups A, B, C, D. Group A included skin samples with < 1day old bruises, group B included skin samples with 1-3 days old bruises, group C included skin samples with 3-7 days old bruises, and group D included skin samples with 7-14 days old bruises. Paraffin sections of the skin stained with Hematoxylin-eosin, Giemsa, Perl’s Prussian Blue and Masson-Goldner methods were evaluated by light microscopy and photodocumented,using stereological method for cell count and photodocumented.Histologicalanalysis in group A showed presence of dilated fibrous septa in dermis and hypodermis with extravasated erythrocytes and intense infiltration with neutrophils. In group B there was initial infiltration by macrophages. Group C also showed presence of macrophages, but itwas significantly more expressed than in group B (p<0.001). Group D showed a significant presence of macrophages when compared to groups B and C (p<0.001).Infiltration with neutrophils occurred shortly after the initiation of the bruise, while after few days of initiation, usually 1-3, there was macrophage infiltration. Presence of macrophages significantly increased as bruises age. These histological characteristics speak in favor of healing the bruises. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Correlation Between Microvessel Density and Morphological Features in Skin Squamous Cell Carcinoma(Walter de Gruyter GmbH/Macedonian Academy of Sciences and Arts, 2017-03-01); ; ; ; Abnormal angiogenesis is described in tumor growth and it facilitates its metastatic spread. Tumors with high angiogenic activity belong to the category of aggressive tumors with poor prognosis for patients. The aim of this study was to determine the blood vessels density (BVD), i.e. neovascularization at the tumor invasive front in skin squamous cell carcinoma (SCC) in order to determine its possible role in the tumor progression, and to correlate it to the blood vessels density of healthy skin and with the prognostic parameters of the TNM classification: T status, depth of tumor invasion (DI) and tumor histological grade (G), which were also correlated between each other. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The depth of the stromal invasion of cutaneous squamous cell carcinoma in correlation with tumor size and tumor differentiation(Macedonian Association of Pathology, 2016-09); ; ; ; Objective: The aim of this study was to determine the correlations between stromal invasion and the grade of differentiation as well as tumor’s size in squamous cell carcinoma of the skin (SCC). Material and Methods: Surgically resected skin specimens from 30 patients with cutaneous SCC, were included in the study. The hematoxylin-eosin stained histological sections containing the tumor tissue and the surrounding normal skin prepared from routinely processed paraffin blocks were analyzed by light microscopy. In each analyzed SCC, the degree of histological differentiation (G) and the postoperative tumor status (pT) of the neoplasm according to TNM classification (AJCC) were determined. The depth of stromal invasion in each case was measured on low power field (x40) using morphometry software. The distance from the basement membrane of the epidermis to the deepest invasive neoplastic focus of the tumor and the obtained values are presented in absolute numbers expressed in micrometers. Results: The SCC in 21 (70%) cases was classified as pT1 and in 9 (30%) cases as pT2 category tumor. Twelve tumors (40%) were classified as well (G1), 13 (43.3%) as moderately (G2), and 5 (16.7%) as poorly (G3) differentiated tumors. The depth of stromal invasion was ranging from 1561.2 μm to 13000.1 μm. A statistically significant difference was found between the depth of invasion in tumors belonging to different pT category (Mann-Whitney U test, p=0.003034 for pT1 and pT2), and different grade (Kruskal-Wallis test, p=0.00008 for G1, G2, G3). Conclusions: The depth of stromal invasion was higher in larger SCCs with a maximal diameter greater than 2 cm (pT2) and in poorly differentiated (G3) tumors. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A survey for students’ experience in small group learning classroom of histology(Macedonian Association of Anatomists, 2019); ; ; Small group learning during practical sessions of histology & embryology was adopted to overcome students’ ‘authority-dependence’ and to enable creative thinking and learning in a socially cohesive group, for enhancing the learning process and developing certain skills. The study aims to identify students’ perception of the usefulness (in general) as well as of certain advantages of the learning process and gaining self-confidence. Online survey consisting of 13 questions/statements the students are supposed to give opinion on, by stating degree of agreement. Results are based on a four grade Likert type scale of evaluation. About half of the students practicing small group learning for the first time, expressed a strongly positive opinion in the survey. They find this method of cooperative learning favorable for: enhancement of the learning process, rational organization of time, conclusion drawing, learning how to apply knowledge in practice, rising motivation. Over all, students practicing small group learning for the first time find the cooperative learning very useful. They elucidate its positive effect on time organization and rationalization of the learning process and knowledge applying. The findings are encouraging and motivating for our continuous work with small group learning. They also highlight the need of working on improvement and creating additional ways to promote students’ participation - especially in questioning, answering and statement elaborating. This project has got ethical approval from the Committee for ethical research with humans. The survey which is part of the project was performed with the understanding and consent of the students. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Morphological Characteristics of the Stroma in Malignat Epithelial Neoplasms with Short Review of Skin Squamous Cell Carcinoma(Македонско лекарско друштво = Macedonian medical association, 2014-04-01); ; ; ; The stroma of the neoplasm is a highly complex structure built by: specialized mesenchymal cells typical for each tissue surroundings, cancer associated fibroblast/myofibroblast, congenital or acquired immune cells, vascular network with endothelial cells and pericytes, mastocytes, macrophages, leukocytes and adipocytes, all together incorporated in the extracellular matrix. Each neoplasm produces its own unique microenvironment where the tumor grows and modifies. Although most of the cells of the host in the stroma have compulsory tumor suppressor ability, the stroma is changing during the malignant process and it even promotes growth, invasion and metastasis. Genetic changes that occur during the development of the cancer, which are guided by the malignant cells lead to changes in the stroma of the host that will overtake it and adjust it to their own needs. In the early stages of the tumor development and invasion, the basal membrane is degraded and the stroma becomes active and contains an increased number of fibroblasts, inflammatory infiltrate and newly composed capillaries which come into direct contact with the tumor cells. These changes lead to cancer invasion. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of Density of Neovascularization in Lower Lip Squamous Cell Carcinoma in Relation to Neoplasm Differentiation Grade in Patients with and without Neck Lymph Nodes Metastasis(ID Design Press, 2019); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Determination of the density of neovascularization in invasive front in skin squamous cell carcinoma, with varying degrees of histological differentiation(Turkish Society of Anatomy and Clinical Anatomy (TSACA), 2015); ; ; ; Introduction: Angiogenesis is a process of formation of new blood vessels from the existing normal capillaries. Tumors with higher angiogenesis activity belong to the category of very aggressive tumors. Aim of this paper is determination of the density of the blood vessels, i.e. neovascularization in the invasive front of the tumor stroma in skin squamous cell carcinoma (SCC) in relation to the healthy skin and the ratio of the density of the blood vessels in the skin SCC with a different degree of histological differentiation. Methods: The material is consisted of operational materials from 30 patients with skin SCC. Neoplasms were classified according to the degree of histological differentiation (G). Histological sections of the invasive front of the neoplasms, the tumor tissue and the surrounding healthy skin were stained immunohistochemically using specific primary monoclonal antibodies SMA and CD34 and analyzed by light microscopy. The density of the blood vessels in the skin SCC in relation to the dermis of the healthy skin was determined, and the density of the blood vessels in neoplasms in relation to the degree of histological differentiation(G). Results: The histological analysis has shown high statistical difference in the density of the blood vessels in the invasive front of skin SCC compared to the healthy skin (Mann-Whitney U, p=0.0000001). The difference found in the density of neovascularization in the neoplasms with different degree of differentiation (G1, G2, G3) is statistically significant for (Kruskal-Wallis, p=0.0003). Conclusion: The density of the neovascularization changes considerably compared to the healthy skin. Depending on the degree of histological differentiation of the neoplasms, the found differences in the density of the blood vessels are statistically significant and there is positive correlation between them. The increase of vascularity in the invasive front of the neoplasm in a higher grade cancers suggest about its possible role in the progression of neoplasm. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, REVIVING CRANIAL OUTER TABLE PERFORATIONS AS A MODERN INNOVATION FOR COMPLEX SCALP AVULSION INJURIES RECONSTRUCTION: A CASE REPORT(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023); ; ; ;