Jovanovikj, Rubens

Preferred name

Jovanovikj, Rubens

Official Name

Jovanovikj, Rubens

Alternative Name

Jovanovic R

Rubens Jovanovic

Jovanovik R.

Jovanovic R.

Jovanovic Rubens

Main Affiliation

rubens.jovanovic@medf.ukim.edu.mk

Researcher ID

0000-0002-6574-9333

Now showing 1 - 10 of 64

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Vascular Lipoleiomyoma of the Uterus: an Unusual Case
(2016-12)
Chibisheva, Vesna
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Trajanova, Milka
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Uterine lipoleiomyomas are a rare type of uterine myomas, which have been seldom diagnosed and are less known and still unusual. Histologically they are composed of smooth muscle cells with multiple fat cells and fibrous tissue. Their pathogenesis is still a stigma and their preoperative diagnosis is still questionable. Case report history A 39-year old woman presented at the University clinic for obstetrics and gynecology with complaints of a mild low abdominal and pelvic pain, increased frequency of vaginal bleeding and abdominal distension. Ultrasound examination showed dislocated uterus by a large semisolid tumor, located between the uterus and the urinary bladder. This mass was not well defined and had great vascularity. Pelvic computerized tomography revealed a large heterogeneous tumor located behind the bladder, measuring 8.5x7.5cm in size, making compression on the other pelvic organs. Conclusion: We should pay more attention on the preoperative imaging studies, in order to select patients who require surgery and further treatment more appropriately.
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Demographic and Clinical Features of Thyroid Carcinomas in Republic of Macedonia (1999-2010)
(ID Design 2012/Scienfitic Foundation SPIROSKI, 2017-12-15)
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Thyroid carcinomas (TC) are the most common endocrine malignancies. In some parts of the world, the incidence of TCs has increased over the past few decades, especially in females according to some studies.
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SERTOLI-LEYDIG CELL TUMOR OF THE OVARY AS AN INCIDENTAL FINDING IN A PATIENT UNDERGOING HYSTERECTOMY DUE TO RECURRENT ABNORMAL UTERINE BLEEDING
(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2023)
Stojchevski, Sasho
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Sertoli-Leydig cell tumor (SLCT) of the ovary is a rare neoplasm that accounts for only 0.5% of all primary ovarian neoplasms. Clinical and histopathological presentations of the tumor are different, which makes diagnosis and treatment difficult. We present a case of a 67-year-old female patient, who presented at the University Clinic for Gynecology and Obstetrics with abnormal uterine bleeding. Explorative curettage was performed for the second time after 1 year, with a histopathological finding of endometrial hyperplasia. The patient underwent an excision of a lung tumor 2 years ago, with a histopathological finding of synovial sarcoma of the lungs, after which she received adjuvant chemotherapy. On transvaginal ultrasonography, the patient had no suspicious pathological findings on the uterus and ovaries. Laboratory tests of tumor markers did not show any elevation. Due to recurrent abnormal bleeding from the uterus, the patient underwent an abdominal hysterectomy with bilateral adnexectomy. Histopathology: Sertoli-Leydig tumor of the right ovary with retiform histoarchitectonics, stage IA and atypical endometrial hyperplasia. Sertoli-Leydig cell tumors have a relatively good prognosis, but their management, surgical treatment and postoperative follow-up due to their rarity is a challenge even today.
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EP778 The role of the E-cadherin/β-catenin signal transduction pathway in the prognosis of advanced stage high-grade serous ovarian/fallopian tube cancer
(BMJ Publishing Group Ltd, 2019-11)
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Introduction/Background The aim of the study was to evaluate the correlation between E-cadherin/β-catenin expression and the clinical and pathological parameters that influence the overall survival rate in patients with advanced stage high-grade serous ovarian/fallopian tube cancer Methodology We performed a retrospective cohort study on patients that underwent primary debulking surgery at the University Clinic of Gynecology and Obstetrics, University ‘Ss. Cyril and Methodius’, Skopje, Republic of North Macedonia between January 2010 and December 2015. The following disease characteristics were analyzed: age, stage, nuclear and tumor grade, lymphovascular invasion, the extent of primary debulking, platinum-based chemotherapy resistance and overall survival. Further, we analyzed the expression of E-cadherin/β-catenin by preforming immunohistochemical staining on deparaffinized and rehydrated tissue specimens with specific monoclonal antibodies. Results A total of 84 patients with primary ovarian and 9 patients with primary fallopian tube cancer met the inclusion criteria. The overall survival of patients in the analyzed cohort was 46 months (95% CI 38–53 months). The residual tumor volume after primary debulking surgery was an independent bad prognostic factor with HR=5.32 (p<0.001). The low frequency of expression as well as the weak staining for E-cadherin were independent bad prognostic factors for the survival of these patients with HR=2.7 (p=0.05) and HR=3.38 (p=0.04), respectively. The univariate analysis also identified that the low frequency of expression and weak staining for β-catenin were bad prognostic factors, but the significance was lost in the multivariate analysis. Conclusion In this study, we identified that the residual tumor volume after primary debulking surgery and the low frequency of expression and weak staining for E-cadherin were independent, statistically significant bad prognostic factors for the overall survival of patients with advanced stage high-grade serous ovarian/fallopian tube cancer. Beta catenin expression was not found to be an independent prognostic factor in the multivariate analysis.
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Pigmented papillary carcinoma of male nipple mimicking melanoma
(Springer, 2021-08-31)
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Background and objective: Primary melanomas of breast and carcinomas with pigment rich melanocytes are well known entities. Melanoma in nipple-areola complex is extremely rare and in differential diagnosis must be distinguished between Paget disease, melanoma from extramammary sites and other invasive carcinomas. We present a case of invasive papillary carcinoma of male nipple with melanin laden tumor cells. Methods: A 71-year old male patient presents with lobulated grayish tumor of the right nipple measuring 2x1, 3 cm elevated above the skin surface 1cm. The lesion was surgically removed with skin excision 0,7x 0,5x 0,5cm. The specimen was formalin-fixed and paraffin-embedded, routinely stained with HE. Additional immunohistochemical analysis was performed with CK7, ER, SMA, S-100, and Melan A. Results: The gross specimen on cut sections revealed solid white to brown tumor, well demarcated at the base and ulceration of overlying epidermis. Histomorphology of the sections showed papillary structures with tall columnar cells overlying fibrovascular cores, as well as micropapillary formations. There were areas of solid and cribriform growth pattern. Microcalcifications were diffusely present. There were accumulated melanophages in subepithelial tissue and melanin granules were also found in tumor cells. Immunohistochemical analysis showed that tumor cells were positive for CK7, with strong and diffuse nuclear stain for ER, with complete absence of myoepithelial cell on SMA stain. Melan A and S-100 were negative. Although rare, a diagnosis of pigmented papillary carcinoma was made. Conclusion: Pigmented carcinomas of breast are rare. When they are localized in areolar region the diagnosis should be carefully made to exclude lesions with melanocytic differentiation. The pigmentation should be considered also as a result by proximity to epidermis. The distinction between benign and malignant papillary lesions is quite difficult in most cases. The prognosis of patients with papillary carcinoma is relatively favorable.
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The outcome of Pregnancy with Fetal Primitive Neuroectodermal Tumor
(ID Design 2012/DOOEL Skopje, 2018-08-20)
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Stefanija, Adela
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Josheva, Jasminka
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Fetal intracranial tumours are very rare. The overall incidence is 0.34 per one thousand live birth newborns. According to the new classification of central nervous system tumour (2016), a primitive neuroectodermal tumour of (PNETs) is an embryonal tumour group; these are tumours with high malignancy and belong to group IV (WHO). In our case, we will present a case of PNETs in 28 gestation week old fetus, diagnosed antenatally and confirmed postnatally.
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Chronic Graft-Versus Host Disease - Single Center Experience
(Scientific Foundation SPIROSKI, 2008-09-01)
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Gocev, Georgi
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Novel Ret Mutations in Macedonian Patients with Medullary Thyroid Carcinoma: Genotype-Phenotype Correlations
(Walter de Gruyter GmbH / MANU, 2015-05-01)
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Bogoeva, Biljana
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Medullary thyroid carcinomas (MTCs) are rare neoplasms comprising 2-10% of all thyroid malignnancies. More than 75% are sporadic tumors and the remainder is familial and MEN2 related. Both sporadic and syndromic MTCs frequently show mutations in the RET proto-oncogene. It has been noted that some MTC cases present an indolent, and some an aggressive clinical course. Ki-67 expression is generally low, with documented exceptions, whereas high expression of Bcl-2 has been reported in majority of the cases. Some studies have shown that Ki-67 and Bcl-2 expressions have prognostic value, as well as RET mutational status. We analyzed 20 unrelated MTC cases for Ki-67, Bcl-2 expression and RET mutations and tested their intercorrelations, correlations to the morphologic features and stage of the tumors, as well as their influence on survival. In 13 of the 20 analyzed cases we found 23 sequence changes distributed in exons 8, 10-13 and 16. There were 11 different missense mutations, single nucleotide deletion with frameshift, and 8 different synonymous mutations. Only 4 of the sequence changes have been previously published. Twelve patients (60%) had tumors expressing one or more missense mutations or single nucleotide deletion and 7 of them (35%) had at least one damaging or possibly damaging RET mutation. Most of the tumors had low Ki-67 expression (mean 6.48% of cells) and high Bcl-2 expression (mean 68.3%). Significantly better survival was observed in cases with low Ki-67 (< 6.5%; p < 0.05), high Bcl-2 expression (> 68.3%; p < 0.01) and younger age at diagnosis (< 51 years; p < 0.05).
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TP53 Mutation in Correlation to Immunohistochemical Expression of P53 Protein in Patients with Hepatocellular Carcinoma
(ID Design 2012/DOOEL Skopje, 2018-07-20)
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Chalovska-Ivanova, Viktorija
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BACKGROUND: Mutations causing p53 inactivation are among the most common genetic alterations in human malignant tumours including hepatocellular carcinoma. Detection of p53 gene mutations in patients with hepatocellular carcinoma (HCC) should provide relevant data for the patients from the Republic of Macedonia and should allow the survivals additional therapeutic option as is gene therapy. AIM: We aimed to detect p53 gene mutations in HCC tissue, and to correlate them with the immunoexpression of p53 protein and multiple clinicopathologic characteristics of a tumour. MATERIAL AND METHODS: We analysed thirty patients with HCC for multiple clinic-pathological characteristics. Tumour tissue samples were immunostained for p53 and detection of p53 gene mutations was performed by polymerase chain reaction followed by Sanger sequencing. RESULTS: Changes in p53 gene sequence were detected in four patients (13.33%), one of them a polymorphism and the other three were missense point mutations with p53 immunoexpression of 50%, 0%, 0% and 90%, respectively. All patients with p53 mutations had cirrhosis. Two of them had Hepatitis B infection, moderately differentiated tumour and T2 status. There was one case with a well-differentiated tumour and one with T4 status. All of them were with vascular invasion. The size of the tumours was in the range of 2.5 cm to 16 cm. All 3 mutations were located in exon 7. CONCLUSION: Mutations in p53 gene are not always associated with obviously altered immunoexpression of p53 protein. Detection of p53 gene mutations is necessary in each case because the new therapeutic modalities offer to apply gene therapy.
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The Evaluation of Sentinel Lymph Node Biopsy Using Radiocolloid in First Stage Endometrial Cancer
(Galenos Yayinevi, 2023-06-20)
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Stojchevski, Sasho
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Detection of a sentinel lymph node (SLN) in patients with endometrial cancer (EC) reduces the rate of unnecessary systemic lymph dissection. The aim of this study was to assess the SLN detection rate, accuracy of the method using Tc-99m-SENTI-SCINT and the rate of metastatic nodal involvement in patients with preoperative first stage EC.

Jovanovikj, Rubens

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