Bogdanov, Jane

Preferred name
Bogdanov, Jane
Official Name
Bogdanov, Jane
Main Affiliation
Email
janebogdanov@gmail.com

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    Monitoring Volatile Organic Compounds in Air Using Passive Sampling: Regional Cross-Border Study between N. Macedonia and Kosovo
    (Taiwan Association for Aerosol Research, 2024)
    Mula, Vllaznim
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    Stanoeva, Jasmina Petreska
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    Zeneli, Lulzim
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    Assessment of volatile organic compounds in indoor environments across North Macedonia and Kosovo using passive sampling
    (Society of Chemists and Technologists of Macedonia, 2024-12-28)
    Mula, Vllaznim
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    Petreska Stanoeva, Jasmina
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    Zeneli, Lulzim
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    Berisha, Avni
    <jats:p>Humans are exposed to various volatile organic compounds (VOCs) through ingestion, inhalation, or skin contact, potentially leading to adverse health consequences. In this study, the distribution of vari-ous VOCs in indoor air in North Macedonia and Kosovo was investigated for the first time. From March to December 2023, the monthly relative abundance of VOCs was monitored using Radiello® pas-sive/diffusive samplers, followed by gas chromatography mass spectrometry (GC MS) analysis.A total of 60 samples were collected from 17 sites, where over 70 individual VOCs belonging to several classes were identified. Benzene, toluene, ethylbenzene, and xylenes (BTEX) compounds were the most abundant in the chemical stockroom, contributing up to 77.84 % of the total VOC relative abun-dance. In the printing store/workplace, alkylbenzenes were predominant, comprising 69.72 %. Alcohols and ethers were primarily detected in the coffee shop, whereas organosiloxanes were dominant in the hair salon, accounting for 33.87 % and 54.46 % of the total VOCs, respectively. Terpenes were a significant component in the meat factory, representing 65.78 % of the total VOCs, while hydrocarbons were most prevalent in the oil & lubricants store, accounting for 58.23%. Halogenated compounds were primarily found in the superstore, constituting 20.42 % of total VOCs. The VOC composition results indicate that their presence in indoor environments may pose both acute and chronic health risks.</jats:p>
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    Systematic HPLC/DAD/MSn study on the extraction efficiency of polyphenols from black goji: Citric and ascorbic acid as alternative acid components in the extraction mixture
    (IOS Press, 2021-12-15)
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    BACKGROUND: The beneficial effects of the fruit of Lycium rhutenicum (black goji) have been linked to their polyphenolic profile. OBJECTIVE: Systematic examination of the extraction efficiency of polyphenols from cultivated black goji from Macedonia was carried out using 25 different solvent mixtures containing methanol, acetone or water combined with different acids (hydrochloric, acetic, citric and ascorbic acid). METHODS: An HPLC/DAD/MSn method was used for identification and quantification of phenolic acids, flavonoids, anthocyanins and also spermines and spermidines. RESULTS: The extraction solvent composition was found to have a significant effect on the yield of total as well as specific polyphenols. Pure methanol was found to be more efficient solvent for extraction of total phenolic compounds than pure water or acetone. Ascorbic acid in methanol (2%, m/v) was found to be the most efficient extraction solvent for total phenolic compounds. Aqueous solutions of citric and ascorbic acid gave the highest yield of phenolic acids, spermidines and flavonoids. The anthocyanin content in these extracts was somewhat lower in comparison with the one obtained with methanol/water/ascorbic acid (70 : 28 : 2). The qualitative analysis of the fruits cultivated in Macedonia showed similar polyphenolic pattern and anthocyanin content to the native plant growing in China. CONCLUSIONS: Citric and ascorbic acid can be used as alternative acid components in the extraction mixture.
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    Establishing mass spectral fragmentation patterns for characterization of 1,2 -unsaturated pyrrolizidine alkaloids and N-oxides in Boraginaceae species from Macedonia using LC-ESI-MS/MS
    (Society of Chemists and Technologists of Macedonia, 2022-06-20)
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    Stefova, Elena
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    Cvetanoska, Marinela
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    <jats:p>Pyrrolizidine alkaloids (PAs) are secondary plant metabolites, and their 1,2-unsaturated derivatives, which contain the retronecine, heliotridine, or otonecine type of the necine base, have raised concern due to their ability to form hepatotoxic intermediates and exhibit serious toxic effects. Several hundred individual pyrrolizidine alkaloids and their N-oxides have been identified mostly using liquid chromatography coupled with mass spectrometry, although the number of available reference standards is limited. In this work, characteristic fragment ions and their abundance in the mass spectra of different PAs were used to reveal typical fragmentation patterns for various classes of PAs that can be further employed to distinguish monoesters (retronecine, heliotridine type), open chain diesters and macrocyclic diesters, and corresponding N-oxides. Fragment ions at m/z 120 and 138 were found in all types of PAs with a different relative abundance. Additional observation of fragment ions at m/z 94 and 156 was found to be typical for monoester PAs esterified at position C9 of the necin base, whereas fragment ions at m/z 111 and 172 were characteristic for monoester N-oxides. Fragment ions at m/z 180 and 220 were found to be typical for open chain diesters with esterification at C7 with acetic and angelic acid, respectively, whereas fragment ions at m/z 214 and 254 were characteristic for the respective N-oxides. For the 3ʹ-acetyl PA monoester or open chain diester derivatives, characteristic fragment ions were observed after loss of the acetyl moiety ([M+H]+–60), whereas for macrocyclic diesters and their N-oxides, fragment ions due to the neutral loss of CO were found ([M+H]+–28).</jats:p>
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    Passive sampling-based characterization of volatile organic compounds in Skopje: seasonal trends and source identification
    (Springer Science and Business Media LLC, 2025-10-27)
    Sofronievska, Ivona
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    Sofronievski, Bojan
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    Semi-Quantitative Characterization of Volatile Organic Compounds in Indoor and Outdoor Air Using Passive Samplers: A Case Study of Milan, Italy
    (MDPI AG, 2025-09-16)
    Mula, Vllaznim
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    Zeneli, Lulzim
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    Mehmeti, Valbonë
    This study presents a semi-quantitative characterization of volatile organic compound (VOC) concentrations and their emission sources in indoor and outdoor environments across four residential and laboratory sites in Milan, Italy, during the summer of 2024. Radiello® passive samplers (Fondazione Salvatore Maugeri in Padova, Italy) were employed for VOC collection, followed by gas chromatography–mass spectrometry analysis. The semi-quantitative mean total VOC (TVOC) concentration was 220.8 ± 195.4 µg/m3 for the outdoor air and slightly higher at 243.6 ± 134.3 µg/m3 for the indoor air, resulting in an indoor-to-outdoor relative ratio of 1.10. The outdoor VOC profile was dominated by hydrocarbons, accounting for 80.3% ± 4.6% (173.2 ± 143.8 µg/m3) of TVOCs, followed by aromatic hydrocarbons at 13.3% ± 5.5% (37.2 ± 49.7 µg/m3). Indoors, hydrocarbons also predominated, representing 34.1% ± 15.2% (95.2 ± 80.1 µg/m3) of the TVOCs, followed by terpenes at 20.7% ± 15.5% (49.0 ± 46.4 µg/m3). Other VOC groups contributed smaller fractions in both environments. The emission profiles from cleaning and personal care products were assessed semi-quantitatively to determine their relative percentage contributions to the indoor VOCs. Source attribution was further supported by diagnostic relative ratios—benzene/toluene, toluene/benzene, and (m + p)-xylene/ethylbenzene—which provided insight into dominant emission sources and photochemical aging.
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    Pharmacokinetics of different selenium supplements in healthy individuals and patients with autoimmune thyroiditis after oral administration
    (Society of Chemists and Technologists of Macedonia, 2025-06-24)
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    Stafilov, Trajče
    Selenium is essential for the function of key selenoproteins such as glutathione peroxidase, thiore-doxin reductase, and iodothyronine deiodinase, which have antioxidant properties and support thyroid hormone metabolism. Due to the low selenium content in European soils – particularly in the Southeast-ern regions, supplementation is often recommended, especially for conditions like Hashimoto's thyroidi-tis. However, careful consideration of selenium dosage and pharmacokinetics is crucial, as the margin be-tween essential and toxic levels is very narrow. The aim of this study was to investigate the pharmacoki-netics of selenium absorption and plasma concentration following oral administration of various selenium doses and chemical forms, both in the short and long term, in healthy individuals and patients with auto-immune thyroiditis. Selenium concentrations in blood plasma were measured using electrothermal atomic absorption spectrometry (ETAAS). The study found that L-selenomethionine is absorbed more efficiently than inorganic sodium selenite, with peak plasma concentrations reached and sustained within 6 – 8 hours. Selenium levels remained elevated 48 hours after ingestion compared to baseline. At a daily dose of 200 μg of selenium as L-selenomethionine, plasma selenium concentrations increased by approximate-ly 30 %, and by about 25 % at 100 μg/day, relative to the initial value. Long-term studies showed that plasma selenium concentrations rose significantly after the first month of supplementation, with a slower increase in subsequent months. After supplementation ended, selenium levels declined rapidly. Interest-ingly, no significant differences in selenium absorption or excretion were observed between patients with Hashimoto's thyroiditis and healthy controls.