Krstevska, Marija
Preferred name
Krstevska, Marija
Official Name
Krstevska, Marija
Main Affiliation
Email
marija@eccf.ukim.edu.mk
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Item type:Publication, Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns(Serbian Medical Society, 2012); ; Kojik, LjiljanaIt has been shown that some adipocytokines and their mutual relationship can be indicators of fetal and neonatal growth. Physiological role of leptin and adiponectin in fetal and neonatal growth is not well established. Objectives. The aim of this study was to assess the correlation of the anthropometrics parameters and serum concentration of leptin and adiponectin levels in healthy newborns. Methods. A cohort of 110 neonates, born after uncomplicated singleton pregnancies at term, were classified as AGA (n=60), SGA (n=30) and LGA (n=20) according to the Lubchenco curves. Anthropometric parameters of the neonates: birth weight (BW), birth length (BL), body weight/body length ratio (BW/ BL), Body Mass Index (BMI) and Ponderal Index (PI) were recorded after birth. Results. Mean serum leptin and adiponectin levels in both sexes were not significantly different (male: 1.85±0.75; 29.51±22.89 and female: 2.06±0.99; 31.60±23.51 ng/mL). There was a significant difference between leptin levels in AGA and LGA newborns (1.93±0.84 vs. 3.12±1.50 ng/mL) (p<0.05), and in adiponectin levels between AGA and LGA compared to SGA newborns (32.8±23.29 and 43.40±31.24 vs. 12.67±2.43 ng/mL, respectively; p<0.05; p<0.05). Leptin and adiponectin levels were positively correlated with BW (r=0.63 and r=0.41), BL (r=0.63, r=0.42), BW/BL (r=0.61, r=0.41), BMI (r=0.54, r=0.35), and PI (r=0.47, r=0.29, (p<0.01). Conclusion. Significantly higher adiponectin levels were found in AGA neonates compared to SGA neonates. Leptin and adiponectine levels were positively correlated with birth weight. These findings suggest that these adipocytokines may be involved in fetal growth regulation. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis(Panstwowe Wydawnictwo Naukowe, 2008); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, VASCULAR COMPLICATIONS IN PATIENTS WITH DIABETES MELLITUS TYPE 2 AND CORRELATION WITH ELEVATED HOMOCYSTEINE LEVELS AS A RISK FACTOR(2020-01); ; Background Elevated homocysteine levels (tHcy), oxidative stress and prolonged hyperglycemia are considered as potential factors for vascular endothelial damage. Correlation between elevated plasma homocysteine and microvascular or macrovascular complications of diabetes mellitus patients, and its possible role as an early predictor for endothelial imparement, is a scientific challenge up to date.Methods diabetes mellitus type 2 more than 12 months, glycosylated haemoglobin HbA1c ≥ 7,5%, BMI ≤ 40 kg/m2 and prescribed oral antidiabetic drugs (OAD) and / or insulin therapy, divided into two groups: 50 patients diagnosed with vascular complications and 30 patients without vascular complications. Complete haemogram, glycemic profile. HbA1c, lipid prorenal function tests, plasma tHcy levels, ultrasound, doppler sonography, blood preasure measurements, oftalmoscopy and urine test for microalbuminuria were performed in each patient. ResultsElevated levels of homocysteine within 16,05 ± 0,83 μmol/l were detected in the group of diabetic subjects with microvascular and macrovascular complications compared to the group where no complications were diagnosed and levels of homocysteine were 10,44 ± 0,24 μmol/l. Elevated homocisteine levels represent an additional risk factor for endothelial imparement in patients with diabetes Conclusion mellitus type 2. However, further research would provide clear evidence of the impact on endothelial vascular damage and long-term vascular complications - Some of the metrics are blocked by yourconsent settings
Item type:Publication, HOMOCYSTEINEMIA AND GENES MUTATION IN CORONARY ARTERY DISEASE(Croatian Laboratory Associoation, 2019-10); ; ; ; Zumberi, Nagip