Stojovski, Marjan

Preferred name
Stojovski, Marjan
Official Name
Stojovski, Marjan
Main Affiliation
Email
marjan.stojovski@medf.ukim.edu.mk

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    FACTORS INFLUENCING THE EARLY POSTOPERATIVE QUALITY OF LIFE IN PATIENTS TREATED SURGICALLY FOR GYNECOLOGICAL MALIGNANCIES
    (Macedonian association of anatomists and morphologists, 2019)
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    Jovanovska V
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    Tanturovski D
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    Stojchevski S
    ABSTRACT Aim: To evaluate the influence of inherent patient characteristics on early postoperative QoL in patients treated surgically for gynecological malignancies Materials and methods: The study was designed as a prospective cohort study. Patients scheduled for surgical treatment of a gynecological malignancy at the Department of gynecological oncology at the University Clinic of Gynecology and Obstetrics in Skopje, in the period January – December 2018. Quality of life was quantified using a standardized and validated questionnaire (FACT-G) preoperatively and 1 month after surgical treatment. We explored the effect of the following variables: age, BMI, nationality, education, marital status, place of residence, employment, primary location of the neoplasm, disease stage, extent of surgical resection, comorbidities and smoking. Results: Data from 123 patients were included in the final analysis. The average age of patients at the time of recruitment was 58±10 years (range 23-79 years). Eighty-four patients (68.29%) had endometrial cancer, 22 (17.89%) patients had cervical cancer, while 17 (13.82%) patients had ovarian cancer. Postoperative FACT-G scores were significantly lower (p=0.015). A clinically relevant postoperative decrease in quality of life was identified in 51 patients (41.5%). Independent predictors of deteriorated postoperative QoL in this study were: advanced disease stage, extensive surgical resection, comorbidities and higher education. Conclusion: The results illustrate the physical, psychological, and social effects of the surgical treatment on the early postoperative QoL, thereby emphasizing the need for a comprehensive, multidisciplinary approach to the pre and postoperative care of these patients.
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    Computed tomography or magnetic resonance imaging - our experiences in determining preoperative TNM staging of bladder cancer
    (Macedonian Academy of Sciences and Arts, 2013)
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    Lazarova, Aleksandra
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    Comparison Between HPV DNA Testing and HPV E6/E7 MRNA Testing in Women with Squamous Cell Abnormalities of the Uterine Cervix
    (Walter de Gruyter GmbH / MANU, 2019-05-01)
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    Duvlis, Sotirija
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    The aim of the study was to compare the results of two human papillomavirus (HPV) diagnostic techniques: human papillomavirus deoxyribonucleic acid (HPV DNA) testing and human papillomavirus E6/E7 messenger ribonucleic acid (HPV E6/E7 mRNA) testing in women with squamous cell abnormalities of the uterine cervix.
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    A rare case of pleomorphic dermal sarcoma presented during pregnancy, a case report
    (John Wiley & Sons, Inc., 2024)
    Milkovski, Daniel
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    Gjirevski, Vlatko
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    Kijajova, Ivana
    Soft tissue sarcomas are rare tumors arising in mesenchymal tissues and can occur almost anywhere in the body. They are rarely diagnosed during pregnancy. Pleomorphic dermal sarcoma (PDS) are dermal-based malignant tumors that usually present on sun-exposed sites of elderly patients and are morphologically similar to atypical fibroxanthoma (AFX). PDS is considered an aggressive cancer and likely to metastasize and reappear. Early detection and aggressive treatment improve outcomes.
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    Brucellosis in pregnancy: case reports with different outcomes in an endemic region
    (Sestre Milosrdnice University Hospital Center (KBC Sestre milosrdnice), 2020-06)
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    Siskova, Dijana
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    Ridov, Aleksandar
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    Kostoska, Emilija
    Different outcomes of brucellosis in pregnancy regarding the fetus/neonate and the mother are described. Medical records of five pregnant women with brucellosis were retrospectively analyzed. Patients were treated in several departments of infectious diseases in the Republic of Macedonia between 1995 and 2009. The diagnosis of brucellosis was based on clinical findings compatible with the disease supported by detection of specific antibodies. Pregnancy outcomes in patients were as follows: spontaneous abortion, intrauterine fetal death, premature delivery in two cases (one with twin pregnancy) and term delivery. One of the women experienced relapse. Follow-up results of neonates showed no infection and their normal growth and development. Brucellosis, especially if acquired in early pregnancy, can have an impact on pregnancy outcome. In endemic regions, in pregnant women with persisting fever and unspecific manifestations one should always have in mind brucellosis. In these areas, cases with unexplained spontaneous abortion, intrauterine fetal death and premature delivery should also be investigated for brucellosis.
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    INFLUENCE OF BMI ON RESISTIN IN GDM AND NORMOGLYCEMIC WOMEN
    (SHMSHM - AAMD, 2020-01-25)
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    Bogoev, Milcho
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    Bogoeva, Ksenija
    Background: Gestational diabetes melitus is a glucose intolerance which is diagnosed for the first time in pregnancy. It may lead to potentially serious short term and long term maternal, fetal and neonatal complications. In GDM pregnancies biomarkers like resistin are elevated and may provide informations on pathophysiology and prediction of perinatal risk. Aim: to evaluate the average concentration of resistin in GDM and normoglycemic women, influence of body mass index on concentration of resistin in GDM and normoglycemic women. Material and methods: Case control study was made at the University Clinic for obstetrics and gynecology, Skopje in a period of one year. 100 pregnant women were regruted from the pregnant women that performed 75g OGTT in the second trimester for sreening for gestational diabetes melitus. Body mass index was calculated according to the terms of Institute of medicine and pregnant women were divided in 4 groups: GDM BMI>25 (n=25), GDM BMI<25(n=25), normoglycemic BMI>25(n=25), normoglycemic BMI<25(n=25). Serum levels of resistin were analysed with ELISA method. Results: The average values of resistin in GDM were 3.15 ± 2.02 ng/ml vs 1.94 ± 0.8 ng/ml in the control group, p=0.00021. In GDM, BMI>25 average values of resistin were 3.15 ± 2.0, whereas in GDM, BMI<25 resistin was significantly lower, 1.94 ± 0.8, p=0.0003. Pregnant women with GDM and BMI>25 had significantly higher average values of resistin (3.16 ± 2.2 ng/ml vs 2.09 ± 0.7 ng/ml, p=0.029) than normoglycemic women with BMI>25. Also pregnant women with GDM, BMI<25 had significantly higher values of resistin than normoglycemic pregnant women with BMI<25 (3.14±1.8 ng/ml vs 1.77±0.9 ng/ml), p=0.003. Normoglycemic overweight women had insignificantly higher values of resistin vs normoglycemic women with normal weight (2.09 ± 0.7 ng/ml vs 1.78 ± 0.9 ng/ml; p=0.19). Conclusion: The results from the study confirmed that GDM significantly alters the values of resistin. In the group of pregnant women with GDM the values of resistin are significantly elevated in women with BMI>25 vs BMI<25. Both women with GDM, BMI>25 and GDM, BMI<25 had significantly higher resistin than normoglycemic women with same BMI. In normoglycemic pregnant women resistin does not have a significant correlation with BMI.
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    #1081 Evaluation of urinary dysfunction after nerve-sparing radical hysterectomy in patients with cervical cancer
    (BMJ Publishing Group Ltd, 2023-09)
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    Milkovski, Daniel
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    Gjirevski, Vlatko
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    Kijajova, Ivana
    Introduction/Background: Urinary dysfunction is one of the most frequently described postoperative complications after radical hysterectomy. Extensive dissection leads to damage to the pelvic autonomic nerves that innervate the bladder muscles, urethral sphincter and pelvic floor fascia, and thus to urinary dysfunction. The aim of this study is to assess the length of the recovery phase and functional establishment of urinary function after radical hysterectomy type C1. Methodology It is a retrospective cross-sectional study conducted at the University of Gynecology and Obstetrics in the period from January to December 2022 in a total of 33 patients with cervical cancer (stage IA-IIA2) treated with radical hysterectomy. Postoperatively, urinary function was determined by measuring residual urine after appropriate training on the 5th-7th day, a residual volume below 100ml was considered as limit value for well-established urinary function. Results: The average age of the patients in the study was 51 years, the youngest patient was 29 years old, and the oldest 73 years old. The calculated mean length of urinary function recovery was 7.3±1.9 days, with a mean measured residual urine volume of 40.6±26.3 ml. Average time of hospital treatment is 7.7±2.41 days, but no longer than 14 days. Conclusion Monitoring the recovery phase and establishment of urinary function after radical hysterectomy is essential. Good surgical technique with maximum nerve preservation leads to early establishment of urinary function, removal of the urinary catheter and additional urinary complications prevention, shorter hospital stay and better quality of life for patients.
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    РИЗИК ФАКТОРИ НА СКВАМОЗНИТЕ КЛЕТОЧНИ АБНОРМАЛНОСТИ НА ГРЛОТО НА МАТКАТА
    (SHMSHM / AAMD, 2017)
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    Duvlis, Sotirija
    Вовед: Целта на нашата студија беше да ги детектираме најчестите ризик фактори на сквамозните интраепителни лезии и сквамозниот инвазивен карцином на грлото на матката. Материјал и методи: Case-control студија, работена на 192 сексуално активни жени, на возраст од 20 до 59 години, поделени во две групи: испитувана и контролна, на Универзитетските клиники за гинекологија и акушерство и радиотерапија и онкологија во Скопје и на Институтот за јавно здравје на Република Македонија, во периодот од Јануари 2016 година до Јуни 2017 година. Кај сите жени се направи: анкета со специфичен прашалник, ХПВ ДНК тестирање, Nugent-ов скор систем, а по индикација, кај сите жени од испитуваната група и колпоскопска цервикална биопсија со ендоцервикална киретажа за хистопатолошка анализа. Резултати: Анализата на податоците покажа асоцијација помеѓу ХПВ ДНК инфекцијата (хи квадрат тест=4.8204, p=0.028125, p<0.05), бактериската вагиноза (хи квадрат тест=4.1906, p=0.040649, p<0.05) и сквамозните клеточни абнормалности на грлото на матката. Нашата студија покажа дека пониското ниво на едукација за 2,29 пати (OR=2.29; 95%CI: 1.093-4.797) го зголемува ризикот за појава на сквамозни клеточни абнормалности на грлото на матката. Релативниот ризик за сквамозни клеточни абнормалности на грлото на матката, кај пациентките со понизок социјален статус беше 2,59 (OR=2.59; 95%CI: 1.137-5.503). Нашата студија покажа дека пушењето цигари за 2,45 пати го зголемува ризикот за појава на сквамозни клеточни абнормалности на грлото на матката (OR=2.45; 95%CI=1.3165-4.5762). Релативниот ризик за сквамозни клеточни абнормалности на грлото на матката, кај пациентките кои употребувале орални хормонски контрацептивни средства подолго од 5 години беше 3,00. Нашата студија покажа дека раниот прв сексуален однос пред 17 година од животот за 2,14 пати го зголемува ризикот за појава на сквамозните интраепителни лезии и сквамозниот инвазивен карцином на грлото на матката (OR=2.14; 95%CI: 1.0723-4.2821). Анализата на податоците од нашата студија покажа и асоцијација помеѓу сквамозните клеточни абнормалности на грлото на матката и диеталната исхрана (OR=2.11; 95%CI=1.0218-4.3832). Заклучок: Анализата на податоците на нашата студија покажа асоцијација помеѓу сквамозните клеточни абнормалности на грлото на матката и ХПВ ДНК инфекцијата, бактериската вагиноза, нередовните гинеколошки контроли, честиот вагинален исцедок, раниот прв сексуален однос, пушењето цигари, долготрајната употреба на хормонски орални контрацептивни средства и диеталната исхрана. Introduction: The purpose of our study was to detect the most common risk factors for squamous cell abnormalities of the uterine cervix. Material and methods: Case-control study, performed on 192 sexually active women aged 20 to 59, divided into two groups: examination and control, at the University Clinics of Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje and the Institute for Public Health of the Republic of Macedonia, in the period from January 2016 to June 2017. All women were made: a questionnaire, HPV DNA testing, Nugent score system, and by indication, in all women in the study group and colposcopic cervical biopsy with endocervical curettage for histopathological analysis. Results: The analysis of the data showed an association between the presence of HPV DNA infection (chi-square test = 4.8204, p = 0.028125, p <0.05), bacterial vaginosis (chi-square test = 4.1906, p = 0.040649, p <0.05) and the occurrence of squamous intraepithelial lesions and squamous invasive carcinoma of the uterine cervix. Our study showed that the lower level of education for 2.29 times (OR = 2.29; 95% CI: 1.093-4.797) increased the risk of squamous cell abnormalities of the uterine cervix. The relative risk of squamous cell cervical abnormalities in patients with lower social status was 2.59 (OR = 2.59; 95% CI: 1.137-5.503). Our study showed that smoking cigarettes by 2.45 times increases the risk of squamous cell abnormalities of the uterine cervix (OR = 2.45; 95% CI: 1.3165-4.5762). The relative risk of squamous cell cervical abnormalities in patients who used oral hormone contraceptives for more than 5 years was 3.00. Our study showed that the first sexual intercourse before the age of 17 years of life for 2.14 times increases the risk of squamous intraepithelial lesions and squamous invasive cervical cancer (OR = 2.14; 95% CI: 1.0723-4.2821). The analysis of the data from our study also showed an association between squamous intraepithelial lesions and squamous invasive cervical cancer and dietary nutrition (OR = 2.11; 95% CI: 1.0218-4.3832). Conclusion: The analysis of the data of our study showed an association between squamous intraepithelial lesions and squamous invasive cervix cancer and HPV DNA infection, bacterial vaginosis, irregular gynecological controls, frequent vaginal discharge, early first sexual intercourse, cigarette smoking, long-term use of hormonal oral contraceptives and dietary nutrition.
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    Атосибан наспроти конвенционален третман за заканувачко предвремено породување
    (Лекарска комора на Република Северна Македонија, 2023)
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    Ива Панева
    Предвременото породување е најважната причина за неонатален морбидитет и морталитет на светско ниво.