Dokikj, Dejan

Preferred name

Dokikj, Dejan

Official Name

Dokikj, Dejan

Main Affiliation

dejan.dokikj@medf.ukim.edu.mk

Now showing 1 - 10 of 47

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Rhabdomyolysis and Acute Kidney Injury in a Patient with Severe Form of Covid-19 Pneumonia- A Case Report
(Balkan Cities Association of Nephrology, Dialysis, Transplantation and Artificial Organs, 2020)
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Milenkova, Mimoza
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Introduction. The ongoing pandemic with the novel Corona virus poses unprecented challenges for the me- dical professionals worldwide. Acute kidney injury is frequently seen in patients infected with corona virus and often associated with a poor patient outcome. Rhabdo- myolysis has been recognized as one of the possible contributing mechanisms. Case. A 68-year-old man was referred to the emergen- cy department complaining of a dry cough, myalgia, general weakness with devastated energy feeling, chest pain and difficulties in breathing, symptoms he expe- rienced in the past five days. He also noticed that his urine was dark and in reduced amount. Quick antigen test for SARS CoV2 was performed, and the patient found Covid-19 positive. He was admitted at the hos- pital ward in a covid-designated unit. Laboratory findings revealed elevation of the inflammatory markers and elec- trolyte disbalance. Metabolic degradation products were markedly increased, serum urea was 44mmol/L (RF=2.7- 7.8 mmol/L) and serum creatinine 689umol/L (RF=45- 109umol/L), when deterioration of the kidney function was diagnosed. Urgent intermittent hemodialysis treatment was initiated. Patient suffered from a severe form of covid-19 pneumonia and was continuously on high flow oxygen mask. Duration of the patient hospitalization was 30 days, and thereafter, he was transferred to the reha- bilitation center for 28 days. Complete restoration of the physical motion and activity was accomplished, oxygen support was no longer needed, since he main- tained blood oxygen saturation above 95%. Renal func- tion has also been recovered with degradation products maintained within normal ranges. Conclusion. Rhabdomyolysis in covid-19 patients should be always kept in mind. Sometimes it can be an initial clinical manifestation in covid-19 patients [15], but on the other hand it can be presented as a late complication sometimes caused by the therapy itself. Multidiscipli- nary and comprehensive approach in the diagnosis, treat- ment and follow up of the patients can only guarantee timely detection and wide range of therapeutical moda- lity, leading to a better prognosis and outcome.
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The rationality of the use of NIV in elderly patients with acute COPD exacerbation
(European Respiratory Society, 2018-09-15)
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Jovanoski, Smilko
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Obstructive Sleep Apnea and Lipid Abnormalities
(ID-Design/Scientific foundation SPIROSKI, 2017-03-15)
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Georgievski, Oliver
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There has been a great interest in the interaction between obstructive sleep apnea (OSA) and metabolic dysfunction, but there is no consistent data suggesting that OSA is a risk factor for dyslipidemia.
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The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease
(Scientific foundation Spiroski, 2016-06-15)
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Sasha Anastasova
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Angela Debresliovska
BACKGROUND: High blood cholesterol is part of metabolic syndrome and can be caused by medical conditions or bad dietary habits. AIM: The aim of the study was to investigate the prevalence of hypercholesterolemia in privies diagnosed patients with the severe and very severe stage of COPD, which аre stable. MATERIAL AND METHODS: We investigated 100 subjects, all of them smokers, with smoking status >10 years, stratified into two groups: with severe and very severe stage of the disease. It was clinical, randomized, cross-sectional study. Besides demographic parameters and functional parameters, body mass index, cholesterol, LDL, and HDL were investigated. RESULTS: In the group of patients with very severe COPD were recorded significantly higher average values of cholesterol (6.16 ± 1.5 vs.5.61 ± 1.1,p = 0.039). As independent significant factors influencing cholesterol in the group with a very severe COPD were confirmed the age of the patients (p = 0.005), LDL (p = 0.004) and HDL (p = 0.002). In the group with severe COPD, only LDL was confirmed as an independent significant factor that has an impact on cholesterol (p <0.0001). CONCLUSION: The results of our survey demonstrated a high level of blood cholesterol and LDL, and low level of blood HDL in both investigated group’s patients with COPD
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Comorbid Conditions in a Cohort of Inpatients with SARS-CoV-2 and their Association with In-Hospital Mortality During the Early Phases of the Pandemic
(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2023-12-01)
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Cibrev, Dragan
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Chamurovski, Nikola
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Introduction: Studies determined that age and associated comorbidities are associated with worse outcomes for COVID-19 patients. The aim of the present study is to examine previous electronic health records of SARS-CoV-2 patients to identify which chronic conditions are associated with in-hospital mortality in a nationally representative sample. Materials and Methods: The actual study is a cross-sectional analysis of SARS-CoV-2 infected patients who were treated in repurposed hospitals. The study includes a cohort of patients treated from 06-11-2020 to 15-03-2021 for COVID-19 associated pneumonia. To examine the presence of comorbidities, electronic health records were examined and analyzed. Results: A total of 1486 in-patients were treated in the specified period, out of which 1237 met the criteria for case. The median age of the sample was 65 years. The overall in-hospital mortality in the sample was 25.5%, while the median length of stay was 11 days. From whole sample, 16.0% of the patients did not have established diagnoses in their electronic records, while the most prevalent coexisting condition was arterial hypertension (62.7%), followed by diabetes mellitus (27.3%). The factors of age, male gender, and the number of diagnoses showed a statistically significant increase in odds ratio (OR) for in-hospital mortality. The presence of chronic kidney injury was associated with the highest increase of OR (by 3.37) for in-hospital mortality in our sample. Conclusion: The study reaffirms the findings that age, male gender, and the presence of comorbidities are associated with in-hospital mortality in COVID-19 treated and unvaccinated patients. Our study suggests that chronic kidney injury showed strongest association with the outcome, when adjusted for age, gender, and coexisting comorbidities.
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Relationship between Vitamin D, Inflammation and Lung Function In Patients with Severe Uncontrolled Asthma
(Scientific Foundation SPIROSKI, 2017-12-15)
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Jovkovska-Kaeva, Biserka
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Breskovska, Gorica
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Goseva, Zlatica
BACKGROUND:Recently epidemiological studies showed that low vitamin D is linked toairway hyperresponsiveness, decreasedlung function, poor asthma control, and steroid–resistant asthma.AIM:We investigatedtherelationshipbetween Vitamin D, inflammation with circulating IL-33 and lung function in 30 patients with severe uncontrolled asthma. MATERIALS AND METHODS:The study included 30 patients with severe uncontrolled asthma. In each of them were measured serum levels of IL-33 and Vitamin D by the ELISA method. The pulmonary function is measuredby basic spirometry parameters, FEV1. The results were statistically elaboratedaccording to the Pearson’s Correlation Tests. RESULTS:The results showed statistically insignificant correlation between Vitamin D and IL-33, and Vitamin D with FEV1 (Vit.D/IL-33; r=0.11323, p=0.551); (Vit.D/FEV1; r=-0.1005; p=0.597) Correlation between IL-33 and FEV1 is negative but statistically significant (IL-33/FEV1; r=-0.5248; p=0.003). CONCLUSION:Because there arelittle studies about the link between vitamin D and asthma, further research toclarify the mechanism how vitamin D control the activity of CD4+ T cells and the related Th2-type cytokines in the parthenogenesis of asthma.
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The effect of smoking on lung function and respiratory symptoms in population of 25-40 years who worked in state administration
(Здружение на физиолози и антрополози на Македонија, 2016)
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Jovanovski S
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Angelovska I
Among young people, the short-term health consequences of smoking include respiratory and non-respiratory effects, addiction to nicotine, and the associated risk of other drug use. Long-term health consequences of youth smoking are reinforced by the fact that most young people who smoke regularly continue to smoke throughout adulthood. In that aim we investigated 230 subjects from January 2012 to December 2013: 150 males and 80 females, 110 (47,8 %) non-smokers, 80 (34,78 %) smokers and 40 (13 %) ex-smokers, age between 25 and 40 years, who worked in state administration. Smoking impairs lung function: lower FEV1 values in smokers were found compared to non-smokers. Smoking increase cough and sputum production. In our survey, a significantly higher frequency of symptoms was observed in smokers compared to nonsmokers. We did not prove the influence of smoking on wheezing or breathlessness.
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Assessment of infectious etiology in severe exacerbations of chronic obstructive pulmonary disease; relationship with respiratory failure
(Macedonian Association of Anatomists, 2021)
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Debreslioska Angela
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Miletic Milena
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Karanfilova Grueva Ada
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Correlation between detected respiratory pathogens and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease
(Македонско лекарско друштво = Macedonian medical association, 2021)
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Leukotriene receptor antagonist (LTRA) added to regular preventive therapy: inhaled corticosteroids and longacting beta agonists (ICS/LABA) in patients with severe uncontrolled asthma
(Macedonian Pharmaceutical Association, 2020-10-29)
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Goseva, Zlatica

Dokikj, Dejan

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