Trajkovska dokikj, Elena
Preferred name
Trajkovska dokikj, Elena
Official Name
Trajkovska dokikj, Elena
Main Affiliation
Email
elena.dokic@medf.ukim.edu.mk
29 results
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Item type:Publication, Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease(Academy of Medical Sciences of Bosnia and Herzegovina, 2012); ; Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of VITEK-2 yeast susceptibility test for antifungal susceptibility testing of Candida species to fluconazole(Македонско лекарско друштво = Macedonian Medical Association, 2011); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Susceptibility profile of Candida parapsilosis in critically ill neonates determined with VITEK-2 antifungal susceptibility method(INSTITUTE OF PUBLIC HEALTH OF REPUBLIC OF NORTH MACEDONIA, 2011); ; ; ; Progressive increase in the incidence of serious fungal infections during the last decades has been registered. Although spectrum of fungi causing serious infections continues to expand, Candida species remains responsible for most of them. C.albicans is still the most frequent etiological agent, but shift towards non-albicans Candida species has been noticed. From recently, C.parapsilosis is an emerging pathogen that has increased in significance and prevalence. Premature born neonates and patients in intensive care units are at highest risk for severe infection. Due to emerging resistance in Candida species to antifungal agents, there is a need for determination of susceptibility profile of clinically significant yeasts. The aim of this study was to investigate the susceptibility profile of ten blood cultures’ isolates of C.parapsilosis from critically ill neonates to fluconazole, voriconazole and amphotericin B. Antifungal susceptibility testing of all isolates was performed with the automated VITEK-2 method. All isolates of C.parapsilosis were susceptible to the investigated antifungal agents. The emergence of C.parapsilosis as the leading non-albicans Candida species in the etiology of candidemia in critically ill patients poses a major threat for the future. The VITEK-2 system is the first automated approach to antifungal susceptibility testing and provides optimal susceptibility test standardization. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phenotypic and genetic relationship of Acinetobacter Baumannii isolates(Македонска академија на науките и уметностите, Одделение за биолошки и медицински науки = Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences, 2011); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, THE ROLE OF THE FAECAL SAMPLES CULTIVATION IN THE DIAGNOSTICS OF CLOSTRIDIOIDES DIFFICILE INFECTION(University Ss. Cyril and Methodius in Skopje, 2025-11-25); ; ; ; <jats:p>Introduction: Clostridioides difficile is one of the most important intra-hospital pathogens. A few years ago, a new diagnostic algorithm for Clostridioides difficile infection (CDI) was introduced by ESCMID, stating that cultivation of the bacteria is not necessary for the diagnosis of CDI. Aim: We aimed to explore the role of the cultivation of faecal samples in the diagnosis of CDI. Materials and Methods: In 4 years, we have cultivated 80 different strains of C. difficile from as many patients. Initially, 1380 faecal samples from CDI-suspected patients were planted on selective and non-selective blood agar media and were accordingly incubated in order to isolate the strains. Quick immuno-chromatographic tests were performed on each faecal sample for detection of GDH (glutamate dehydrogenase) and C. difficile toxins A and B as well as on each confirmed C. difficile isolate (from one colony-toxins detection only). Results: In 14 of the 80 faecal samples from which the isolates originated, toxins A and B have not been detected. In 8 of these 14 strains, toxins A and B were detected only from the culture. Only 6 strains were confirmed as non-toxigenic. Conclusions: Although there was no statistical significance, the detection rate of C. difficile toxins A and B was higher from the culture than from the faecal samples by up to 10%. Cultivation of the samples for C. difficile could reduce the rate of false negative findings for CDI.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ANTIBIOTICS: CURE AND RISK FACTOR FOR CLOSTRIDIOIDESDIFFICILE INFECTION(Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 2024-04-22); ; ; ; Introduction: The major risk factor for acquiring an infection with Clostridioides difficile (CDI) is a long-term antibiotic treatment. Contrarily, the treatment of severe CDI cases involves application of antibiotics like vancomycin or metronidazole. Our aim was to investigate the percentage of resistance to eight antibiotics (vancomycin, metronidazole, tetracycline, clindamycin, erythromycin, imipenem, ciprofloxacin and moxifloxacin) among Clostridioides difficile isolates, indirectly evaluating the risks of acquiring CDI and the risks of therapeutic failure. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Multiplex PCR in diagnosis of invasive infections with Candida species(Medical Facilty, Ss Cyril and Methodius University, Skopje, R Macedonia, 2016); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antimicrobial Susceptibility of Campylobacter isolates in the Capital of North Macedonia(Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2019-10-01); ; ; ; Aneta BlazevskaBackground: Campylobacter infections are typically self-limited, but in cases with severe enteritis, immu-no-compromised system and bacteremia, an appropriate antimicrobial treatment is demanding. Our study aim was to determine the isolation rate of Campylobacter among patients with acute enteritis in the capital of North Macedonia and its antimicrobial susceptibility. Material and methods: A total number of 3820 patients clinically diagnosed as acute enteritis, were includ-ed in the study. Stool samples were collected and Campylobacter was isolated and identified by classical microbiological methods. Antimicrobial susceptibility of all isolates to Ceftriaxone, Amoxicillin-clavulonic acid, Erythromycin, Ciprofloxacin, Tetracycline and Gentamicin was determined by disc-diffusion technique. Additionally, minimal inhibitory concentrations of all Campylobacter isolates against erythromycin, cipro-floxacin and tetracycline were determined by Epsilon gradient tests.Results: Campylobacter species was isolated in 97 patients. Although the mean isolation rate of Campylobacter spp. during the whole study period was 2.53%, a statistically significant increase was detected in 2016 and 2017, in comparison with the data from previous four years of the study. The isolation rate of Campylobacter spp. didn’t reveal statistically significant difference between males and females (p > 0.05). 46.4 % of patients with Campylobacter enteritis were children at the age under 15 years. Forty-three C. jejuni isolates were susceptible to all six antibiotics, but the remaining 44 isolates revealed resistance to at least one antibiotic. C. coli isolates were resistant to 3 antibiotics simultaneously. Two C. coli isolates only, were susceptible to all 6 antibiotics. 40.90% of C. jejuni and 50% of C. coli isolates were resistant to beta-lactams, fluoroquinolones and tetracyclines, simultaneously. Conclusion: The increase of the isolation rate of Campylobacter from patients with acute enteritis indicates the need for permanent isolation and identification of Campylobacter from every clinically diagnosed patient, as acute enteritis. Erythromicin is the most effective antibiotic for treatment of Campylobacter enteritis in our patients. The high level of Campylobacter resistance to beta-lactams, fluoroquinolones and tetracyclines requires more rational approach in the treatment of Campylobacter enteritis - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Phenotipic and genetic relationship of Acinetobacter baumannii isolates(Macedonian Academy of Sciences and Arts, 2011); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Улогата на пробиотикот “Диастоп пробио” е превенција на колонизација и инфекција со Clostridium difficile кај хоспитализирани пациенти(INSTITUTE OF PUBLIC HEALTH OF REPUBLIC OF NORTH MACEDONIA, 2018); ; ; ;
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