Ristovski, Gligor
Preferred name
Ristovski, Gligor
Official Name
Ristovski, Gligor
Main Affiliation
Email
gligor.ristovski@medf.ukim.edu.mk
7 results
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Item type:Publication, Pigmented papillary carcinoma of male nipple mimicking melanoma(Springer, 2021-08-31); ; ; ; Background and objective: Primary melanomas of breast and carcinomas with pigment rich melanocytes are well known entities. Melanoma in nipple-areola complex is extremely rare and in differential diagnosis must be distinguished between Paget disease, melanoma from extramammary sites and other invasive carcinomas. We present a case of invasive papillary carcinoma of male nipple with melanin laden tumor cells. Methods: A 71-year old male patient presents with lobulated grayish tumor of the right nipple measuring 2x1, 3 cm elevated above the skin surface 1cm. The lesion was surgically removed with skin excision 0,7x 0,5x 0,5cm. The specimen was formalin-fixed and paraffin-embedded, routinely stained with HE. Additional immunohistochemical analysis was performed with CK7, ER, SMA, S-100, and Melan A. Results: The gross specimen on cut sections revealed solid white to brown tumor, well demarcated at the base and ulceration of overlying epidermis. Histomorphology of the sections showed papillary structures with tall columnar cells overlying fibrovascular cores, as well as micropapillary formations. There were areas of solid and cribriform growth pattern. Microcalcifications were diffusely present. There were accumulated melanophages in subepithelial tissue and melanin granules were also found in tumor cells. Immunohistochemical analysis showed that tumor cells were positive for CK7, with strong and diffuse nuclear stain for ER, with complete absence of myoepithelial cell on SMA stain. Melan A and S-100 were negative. Although rare, a diagnosis of pigmented papillary carcinoma was made. Conclusion: Pigmented carcinomas of breast are rare. When they are localized in areolar region the diagnosis should be carefully made to exclude lesions with melanocytic differentiation. The pigmentation should be considered also as a result by proximity to epidermis. The distinction between benign and malignant papillary lesions is quite difficult in most cases. The prognosis of patients with papillary carcinoma is relatively favorable. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Metachronous colon cancer metastasis to abdominal wall 7 years after rectosigmoid resection: a case report and literature review(Oxford University Press (OUP), 2023-12); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, When is surgery indicated in metastatic small intestine neuroendocrine tumor?(Oxford University Press (OUP), 2023-10); <jats:title>Abstract</jats:title> <jats:p>Small intestine neuroendocrine tumors are predominantly small but with high potential for distant metastases development. Diagnosis establishment in early-stage is often difficult and challenging. Small intestine neuroendocrine tumors often initially present with liver metastases. According to the Consensus Guidelines of the North American Neuroendocrine Tumor Society, in patients with liver metastases from unknown origin of primary neuroendocrine tumor, surgical exploration should be performed in order to identify the primary location, prevent small intestine obstruction, and treat one if already present. We present a case of a 69-year-old male patient diagnosed with liver and peritoneal metastases due to small bowel neuroendocrine tumor treated with surgery due to the presence of small intestine obstruction.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Spontaneous omental infarction in an obese young female patient treated with laparoscopy: a case report(Oxford University Press (OUP), 2024-06); ; ; Argirov, IvanPartial infarction of the great omentum is a rare cause of abdominal pain and may present as a surgical emergency. Omental infarction might occur due to its torsion, but cases without obvious cause are reported. Risk factors related to this condition are overweight, obesity, abdominal trauma, recent abdominal surgery, hypercoagulability, postprandial vascular congestion and an increase in intra-abdominal pressure. Because of the condition's rarity, most patients are treated with surgery and the diagnosis is established intraoperatively. Preoperative diagnosis allows successful conservative treatment with analgesics and anti-inflammatory drugs. This case reports a young female patient with class III obesity presented with spontaneous partial infarction of the great omentum treated with laparoscopy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Foetus acardius amorphous - report of two cases(Macedonian Association of Pathology, 2016-09); ; ; Objective: Foetus acardius amorphous is a rare congenital malformation with an incidence of 1:35000 births, which usually is a complication in multiple pregnancies. The main diagnostic dilemma is placental teratoma, a non-trophoblastic, extremely rare tumor, with only 27 cases reported in the literature. We present a case of a triplet pregnancy of a 35-year-old mother and a twin pregnancy of a 32-year old mother. Material and Methods: Case 1. Along with three live births, there was a teratogenic, skin-covered, oval tumor mass, weighing 1450 grams and 21x15x6 cm in size, with two epidermal buds with a diameter of 2-3 cm on the surface. On dissection, there were fatty tissue, muscle, cartilage, bone and large intestinal loops. Case 2. Along with a stillbirth, there was an oval, skin-covered structure weighing 67 grams and diameter of 9.5 cm, with visible elongated bud, resembling a limb, at one pole. The dissection showed autolytic organoid structures and cavities. Results: There are a few criteria for differentiating acardiac fetus from placental teratoma: a presence of umbilical cord, skeletal structures, visible rudimentary extremities and partially developed visceral organs. On the other hand, a placental teratoma is predominantly composed of a disorganized collection of mature tissues. The gross and histological findings solved our diagnostic dilemma. Conclusions: There is a great overlap between these two entities and the proposed criteria are useful only in clear cases. Some authors consider them as different levels of development and differentiation of a single pathological event. Nonetheless, the clinical information for multiple gestation pregnancies is very important and helpful for diagnosing foetus acardiacus. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Gastric schwannoma: a case report(Oxford University Press, 2024-03-27); ; ; ; Kostovska, IrenaGastric schwannomas are rare mesenchymal tumors that arise from the intestinal nerve plexuses. They present with nonspecific symptoms and are often discovered incidentally. We present the case of a 68-year-old patient who had been suffering from abdominal discomfort for 6 months. After a complete examination, including abdominal computed tomography and upper gastrointestinal endoscopy, we discovered a submucosal gastric lesion with benign gross features without evidence of lymph node or metastatic involvement. He underwent an open laparotomy. Final pathohistological and immunohistochemically identification of the surgical specimen established the diagnosis of benign schwannoma. Considering the excellent prognosis of the tumor, no adjuvant treatment was suggested other than simple clinical monitoring every 6 months. Despite the accessibility of advanced endoscopy and imaging techniques, the diagnosis of gastric schwannoma is rarely made preoperatively. In the latter case, the best treatment is still complete excision with wide margins. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Paget breast cancer immunoprofile as Toker's cells: a case report(Springer, 2018-09); ; Background&Objective: Paget's disease or Paget breast cancer is a rare and unusual breast cancer. The appearance of the disease may be associated with invasive or noninvasive tumour mass and rarely without an underlying neoplasm. The aim of this paper is to present a case of Paget’s carcinoma without an underlying carcinoma (PCWUC), arising from Toker's cells. Method: The patient was 70-years old woman with ulcerative and crusted changes of the nipple and areola. We examined a large number of sections taken from biopsy and surgical specimen of the nipple, areola and underlying breast tissue. All slices were processed and stained with standard procedures (haematoxylin–eosin) and immunohistochemical technique. Results: Epidermis and distal lactiferous channels were infiltrated with Paget cells resembling atypical neoplastic altered Toker's cells. Using immunohistochemistry, we found a clear demarcation between normal epithelial cells from malignant cells infiltrate. Cytokeratin 7 was positive only in tumour cells, but high molecular and low molecular weight cytokeratins were only positive in normal epithelial cells. Underlying breast tissue did not contain any tumour cells. Conclusion: The same immunoprofile of Toker's cells and PCWUC cells suggests a common histogenesis.