Antovska, Vesna
Preferred name
Antovska, Vesna
Official Name
Antovska, Vesna
Main Affiliation
Email
vesna.antovska@medf.ukim.edu.mk
44 results
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Item type:Publication, Vascular Lipoleiomyoma of the Uterus: an Unusual Case(2016-12); ; Uterine lipoleiomyomas are a rare type of uterine myomas, which have been seldom diagnosed and are less known and still unusual. Histologically they are composed of smooth muscle cells with multiple fat cells and fibrous tissue. Their pathogenesis is still a stigma and their preoperative diagnosis is still questionable. Case report history A 39-year old woman presented at the University clinic for obstetrics and gynecology with complaints of a mild low abdominal and pelvic pain, increased frequency of vaginal bleeding and abdominal distension. Ultrasound examination showed dislocated uterus by a large semisolid tumor, located between the uterus and the urinary bladder. This mass was not well defined and had great vascularity. Pelvic computerized tomography revealed a large heterogeneous tumor located behind the bladder, measuring 8.5x7.5cm in size, making compression on the other pelvic organs. Conclusion: We should pay more attention on the preoperative imaging studies, in order to select patients who require surgery and further treatment more appropriately. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison Between HPV DNA Testing and HPV E6/E7 MRNA Testing in Women with Squamous Cell Abnormalities of the Uterine Cervix(Walter de Gruyter GmbH / MANU, 2019-05-01); ; ; The aim of the study was to compare the results of two human papillomavirus (HPV) diagnostic techniques: human papillomavirus deoxyribonucleic acid (HPV DNA) testing and human papillomavirus E6/E7 messenger ribonucleic acid (HPV E6/E7 mRNA) testing in women with squamous cell abnormalities of the uterine cervix. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECT OF ADIPOSITY AND FAT DISTRIBUTION ON ENDOMETRIAL CANCER RISK IN POSTMENOPAUSAL PATIENTS(University Ss. Cyril and Methodius in Skopje, 2023); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Influence of hysteroscopic metroplasty on reproductive outcome in patients with infertility and recurrent pregnancy loss(Walter de Gruyter GmbH/Macedonian Academy of Sciences and Arts, 2014); Patients with congenital uterine anomalies (CUA) have decreased reproductive potential and an unfavourable reproductive outcome compared to the population with normal uterine cavity. Patients with untreated CUA have a higher abortion rate, higher foetal loss rate and decreased live birth rate. Hysteroscopic metroplasty is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies. The aim of the study was to analyse the reproductive outcome in certain groups of patients with CUA and infertility, before and after hysteroscopic metroplasty. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The influence on coagulation of transdermal estrogen hormone replacement therapy as a preoperative preparation of the tissue before vaginal hysterectomy(Macedonian Academy of Sciences and Arts, 2004); ; ; ; Kiprovska, GordanaIn 32 postmenopausal patients who underwent vaginal hysterectomy due to the presence of uterine prolapse at the Department of Uro-gynaecology and Pelvic Floor Disorders in the Clinic of Gynaecology and Obstetrics, Medical School, Skopje in the period from 1st January 2002 to 1st January 2003, and who were preoperatively treated with transdermal estradiol 50 microg/day during 14 days the following parameters of the coagulating status were estimated: prothrombin time (PT) that is expressed in: absolute value, percentage and INR; activated partial thromboplastin time (aPTT Pathrombin SL); thrombin time and platelets number before and after hormone replacement therapy. After 14-day transdermal estrogen therapy, the parameters: PT, PT%, PT INR, aPTT Pathrombin SL didn't expressed significant changes, the thrombin time expressed significant extension, and the platelets expressed a significant decrease. According to our results, the transdermal estrogens might not have any influence on the hepatic synthesis of coagulating factors till the step of prothrombin formation. They might have an essential influence on the step of prothrombin transformation into thrombin, as well as on the process of megacaryocytes segregation into platelets. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-risk HPV E6/E7 messenger RNA testing versus HPV DNA testing in women with squamous cell abnormalities of the uterine cervix(BMJ Publishing Group Ltd, International Gynecologic Cancer Society & European Society of Gynaecological Oncology, 2017-11); ; Dabeski, AnaAims The study is performed in order to compare the results of two HPV screening methods: High-risk HPV E6/E7 mRNA and HPV DNA. Method Comparative prospective study, conducted in the period for April 2016 to March 2017 at the University Clinics for Gynecology and Obstetrics and Radiotherapy and Oncology in Skopje and Institute of Public Health of Republic of Macedonia of 98 sexually active women, age groups of 20 to 60 years, with squamous cell abnormalities on the cervical cytology. In all 98 women were done: HPV DNA testing, High-risk HPV E6/E7 mRNA testing and colposcopy and directed biopsy with endocervical curettage for histopathological analysis. Results Histopathologically, there were: 36.7% non-neoplastic lesions, 20.4% LGSIL cases, 29.6% HGSIL cases and 13.3% invasive squamous cell carcinomas. HPV DNA was found 78.6% of the cases; E6 and E7 transcripts were found in 58.2%. The rates of detection of HPV DNA and E6 and E7 transcripts were 83.3% and 22.2% for cases with non-neoplastic finding; 65.0% and 45.0% for cases with LGSIL; 75.9% and 93.1% for cases with HGSIL and 92.3% and 100% for cases with invasive squamous cell carcinoma. High-risk HPV E6/E7 mRNA testing showed a higher sensitivity than the HPV DNA testing (79.0% and 75.8%), higher specificity (77.8% and 16.7%) and a higher positive predictive value for HGSIL ( 93.1% and 75.9%) and invasive squamous cell carcinoma (100% and 92.3%). Conclusion High-risk HPV E6/E7 mRNA testing could be more powerful than HPV DNA testing for screening and investigation of HGSIL and invasive squamous cell carcinoma. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Struma Ovarii: A Rare Ovarian Teratoma and Follicular Adenoma of Thyroid Gland(Austin Publishing Group, 2022); ; ; ; Stojanovska, MIOvarian struma is a germ cell tumor in which thyroid tissue represents more than a half of the tumor and has incidence of 0,3-1% of all ovarian tumors. Most of the patients are asymptomatic and tumor is found incidentally during ultrasound, or with nonspecific symptoms, like pain or abdominal swelling. We report a case of 49-years old woman with no symptoms and an ovarian mass, which was incidentally found during a routine ultrasound examination. On ultrasound she had a tumorous mass on the left ovary with central cystic part filled with dense fluid. Color Doppler showed resistance index RI - 0.64, which did not indicate malignant nature of the tumor, and CA-125 was slightly elevated (38,4 U/ml). The result of the scoring system ROMI was 11 ponts, i.e. low risk for ovarian carcinoma. The patient underwent hysterectomy and bilateral adnexectomy. The final histopathologic report was struma ovarii with well-differentiated neoplasm of uncertain malignant potential. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Uterine artery pulsatility index as a relevant parameter in the prediction of preeclampsia(Macedonian Pharmaceutical Association, 2020-03); ; Mirjana Kaeva PejkovskaPreeclampsia is a clinical syndrome that occurs in 5-10% of pregnancies with increased perinatal morbidity and mortality. According to ISUOG (International Society of Ultrasound in Obstetrics & Gynecology), the use of the uterine artery pulsatility index (PI) is an important sensitive method in predicting the risk of preeclampsia. This study is to emphasize the value of PI as a more relevant predictive parameter in the detection of preeclampsia in the second trimester compared to the presence of isolated uterine artery notch. For the above purpose, 96 patients were examined at the University Clinic of Gynecology and Obstetrics in Skopje, divided into 2 groups: study and control group. The study group consisted of 48 patients from 14 to 20 gestational weeks with present uterine artery notch, being the main inclusion criterion. The control group consisted of 48 pregnant patients at the same gestational age with absence of uterine artery notch. In the study group, 43.7% developed clinical syndrome of preeclampsia. The resistance index (RI) value was up to 0.73 and the predictive value of the RI was 57.1%. In patients who developed preeclampsia syndrome, the value of the PI above 1.75 was of much greater predictive value, with value of 71.4%. The sensitivity of these values was 88%, which is a reliable parameter. PI is a reliable parameter in detecting the risk of developing preeclampsia and an indicator of great clinical significance in the daily practice in perinatology. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Postpartum Juvenile Granulosa Cell Tumor: A Case Report(Austin Publishing Group, 2023-01-25); ; ; ; Akiku Kamberi, ElmedinaGranulosa Cell Tumors (GCTs) are extremely rare, sex cord-stromal tumors constituting only 1% to 2% of all ovarian malignancies. On the basis of age of onset and pathohistological characteristics, these tumors are subdivided into two distinct forms, the adult type (AGCT) and the juvenile type (JGCT), representing 95% and 5% of the tumors, respectively. Compared to the adult type, which is more common in the fifth decade, JGCT is rarely seen and the majority (90%) is reported in prepubertal individuals or those aged less than 30 years. We report an interesting case of a 24-years old woman with enormous ovarian juvenile granulosa cell tumor of the right ovary. Considering all the anamnestic data and ultrasound reports before and during the first pregnancy, where there has been no evidence for the presence of any tumor, we came to conclusion that the tumor grew rapidly during the first year since delivery. Maybe the tumor was present during the pregnancy or even before, but most probably it was not noticed because it small initial size or it was masked by the growing uterus at ultrasound. The first data for the tumor existence is 3 months before the surgical treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, OBJECTIVE METHODS FOR ASSESSMENT OF DEEP MYOMETRIAL AND CERVICAL INVASION IN PATIENTS WITH ENDOMETRIAL CANCER(SHMSHM - AAMD, 2023-12); ; ; Introduction: Endometrial cancer is the most common gynaecological malignancy. This study analyzed different objective methods with transvaginal ultrasonography for the assessment of deep myometrial and cervical invasion in patients with endometrial cancer to choose the optimal surgical treatment. Material and methods: It represents a prospective cohort study in which 45 patients with a histological diagnosis of endometrial cancer were analyzed. They are examined with transvaginal ultrasound to assess deep myometrial and cervical invasion. Results: Objective parameters such as those of Gordon result in a sensitivity of 76% and a specificity of 85% and Carlson with a sensitivity of 72% and specificity 95%. 3D ultrasonography resulted in a sensitivity of 92% and a specificity of 78%. The objective assessment of cervical tumour invasion below the OUI (internal uterine orificum) had a sensitivity of 70% and a specificity of 85%, and the one with a cut-off <20.5mm distance from the OUE (external uterine orificium) to the lower margin of the tumour had a sensitivity of 86% and specificity 75%. Discussion: The therapeutic modality in patients with endometrial cancer depends on several factors such as histological type, nuclear grade, myometrial and cervical invasion, which, if present, require radical surgical treatment and the need for evaluation of lymph nodes for appropriate surgical staging. Conclusion: The obtained results are comparable with relevant works on this issue. Transvaginal ultrasonography is similarly effective to nuclear magnetic resonance for assessing deep myometrial and cervical invasion.