Now showing 1 - 10 of 31
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    Risk scoring for Alzheimer's disease in individuals with family history
    (S. Karger AG, 2015)
    Novotni, Gabriela
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    Novotni, A
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    Aleksovski, V
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    Intracerebral Hematoma, Perihemorrhagic Edema and Urinary Excreted Cysteinyl Leukotrienes Correlation Study
    (Walter de Gruyter GmbH, 2014-08-01)
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    Nikodijevic, Dijana
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    <jats:title>Abstract</jats:title><jats:p><jats:bold>Introduction.</jats:bold>Several mechanisms in formation of perihemorrhagic edema are activated after contact of brain tissue-extravasated blood in intracerebral hemorrhage. Cysteinyl leukotrienes (cysLT) (C4, D4, E4) are included in this process as significant edema factors and they determine the neurological deficit and outcome. The study aim was a 5-day follow-up (admission/3 day/5 day) of urinary cysLT, hematoma volume, edema volume values and their correlation in patients after spontaneous, primary supratentorial intracerebral hemorrhage.</jats:p><jats:p><jats:bold>Methods.</jats:bold>An enzyme immunoassay was used for urinary cysLT measured in 62 patients and 80 healthy controls. Hematoma and edema volumes were visualized and measured by computed tomography and mathematically calculated with a special spheroid shape formula (V=AxBxC/2).</jats:p><jats:p><jats:bold>Results.</jats:bold>CysLT of hemorrhagic patients (1842.20±1413.2, 1181.54±906.2, 982.30±774.2pg/ml/mg creatinine) were significantly excreted (p<0.01). Brain edema (12.86±13.5, 22.38±21.1, 28.45±29.4cm<jats:sup>3</jats:sup>) was significantly increased (p<0.01). Hematoma volume values (13.05±14.5, 13.13±14.7, 12.99±14.7cm<jats:sup>3</jats:sup>) were not significant (p>0.05). A high correlation (multiple regression) between cysLT, hematoma and edema was found on the 3<jats:sup>rd</jats:sup>day (R=0.6) and a moderate correlation at admission (R=0.3) and on the 5<jats:sup>th</jats:sup>day (R=0.3).</jats:p><jats:p><jats:bold>Conclusion.</jats:bold>In our 5-day follow-up study a significant cysLT brain synthesis and significant brain edema progression versus constant hematoma volume values in hemorrhagic patients was found. A high correlation between cysLT, hematoma and edema volume was found on the 3<jats:sup>rd</jats:sup>day, a moderate correlation on admission and on the 5<jats:sup>th</jats:sup>day, which means that high cysLT and hematoma values were associated with high/moderate edema values.</jats:p>
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    Cysteinyl leukotrienes and hematoma-correlation study
    (League against Epilepsy of Macedonia, 2016)
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    Nikodijevic, Dijana
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    Baneva, Emilija
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    Refractory Epilepsy-MRI, EEG and CT scan, a Correlative Clinical Study
    (ID Design 2012/DOOEL Skopje, 2016-03-15)
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    Refractory epilepsies (RE), as well as, the surgically correctable syndromes, are of great interest, since they affect the very young population of children and adolescents. The early diagnosis and treatment are very important in preventing the psychosocial disability. Therefore MRI and EEG are highly sensitive methods in the diagnosis and localization of epileptogenic focus, but also in pre-surgical evaluation of these patients. The aim of our study is to correlate the imaging findings of EEG, MRI and CT scan in refractory symptomatic epilepsies, and to determine their specificity in detecting the epileptogenic focus.
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    Legal Issues of Patients with epilepsy - a 5 year study
    (League against Epilepsy of Macedonia, 2016)
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    Kedeva, K
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    Chavdar, K
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    THE EFFECT OF PLASMA PREPARATION RICH IN GROWTH FACTORS ON PATELLAR STABILITY AFTER MEDIAL PATELLOFEMORAL LIGAMENT REEFING
    (Association of medical doctors "Sanamed" Novi Pazar, 2016)
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    Nanceva, Andrea
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    Introduction: Although more than 100 operative procedures have been described for the treatment of patellar instability, there is no single universally successful procedure. For the most patients with lateral patellar instability medial patellofemoral ligament (MPFL) reefing is recommended. When we perform MPFL reefing we are not aware of the quality and strength of the MPFL tissue. In the presence of recurrent patellar instability,the quality and strength of MPFL tissue is often compromised and it disturbs patellar stability after MPFL reefing. Biomedicine development,recognizing the ligament healing process show us that autologous blood products, particularly PRP can enhance healing in soft tissue injuries. Purpose: The purpose of this study was to determine the potential effect of Plasma preparation rich in growth factorson patellar stability after MPFL reefing. Material and methods: Plasma preparationrich in growth factors was produced from a unit of autologous whole blood using Arthrex ACP double syringe system.Platelet gel was prepared by adding bovine thrombin and 10% solution of calcium chloride.The platelet gel was applied locally into the place where suturing of the MPFL was performed. In this prospective, randomized and double blindstudy12 patients were included:6 patients in the PG group who received platelet gel and 6 patients in the control group who were not treated with platelet gel. Patellar stability was evaluated before surgery and 3 months after surgery with Axial stress radiographs. Results: The calculated 3 month improvement was 12.67 2.51 in the control group and 17.33 1.52 in the PG group, (p=0.064).Although there was greater improvement in patellar stability in PG group comparing to the control group, the difference was not statistically significant (p>0.05).The main reason for this was probably the small number of patients included in the study. Conclusion: Results showed that growth factors from the plasma preparation rich in growth factorshave positive effect on patellar stability after MPFL reefing.We believe that they stimulate and accelerate physiological healing and reparative tissue processes in ligament healing. More studies should be made, including more patients, if we want to get more relevant results.
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    Painful diabetic neuropathy: Clinical Approach
    (Macedonian Ophtalmologists Society, 2018)
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    Medjiti, Fatmir
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    Correlative study between serum matrix metalloproteinase-9 values and neurologic deficit in acute, primary, supratentorial, intracerebral haemorrhage
    (Walter de Gruyter GmbH, 2014)
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    Chepreganova-Changovska, Tatjana
    One of the essential characteristics of intracerebral haemorrhages (ICH) is the occurrence of brain oedema (BE). Matrix metalloproteinase-9 (MMP-9) belongs to the family of proteolytic enzymes connected with zinc, which in brain bleeding or a stroke can induce matrix proteolyse into the neurovascular unit, and increase the BE. The aim of the study was to determine the MMP-9 values in serum, and to assess the degree of correlation with neurological deficit in patients with acute, primary and supratentorial ICH.
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    Spectrum of functional neurological disorders
    (2018)
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    Medjiti, Fatmir
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    Mitrevska-Velkov, Jasmina