Faculty of Dentistry
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Item type:Publication, FACTORS INFLUENCING THE EARLY POSTOPERATIVE QUALITY OF LIFE IN PATIENTS TREATED SURGICALLY FOR GYNECOLOGICAL MALIGNANCIES(Macedonian association of anatomists and morphologists, 2019); ;Jovanovska V; ;Tanturovski DStojchevski SABSTRACT Aim: To evaluate the influence of inherent patient characteristics on early postoperative QoL in patients treated surgically for gynecological malignancies Materials and methods: The study was designed as a prospective cohort study. Patients scheduled for surgical treatment of a gynecological malignancy at the Department of gynecological oncology at the University Clinic of Gynecology and Obstetrics in Skopje, in the period January – December 2018. Quality of life was quantified using a standardized and validated questionnaire (FACT-G) preoperatively and 1 month after surgical treatment. We explored the effect of the following variables: age, BMI, nationality, education, marital status, place of residence, employment, primary location of the neoplasm, disease stage, extent of surgical resection, comorbidities and smoking. Results: Data from 123 patients were included in the final analysis. The average age of patients at the time of recruitment was 58±10 years (range 23-79 years). Eighty-four patients (68.29%) had endometrial cancer, 22 (17.89%) patients had cervical cancer, while 17 (13.82%) patients had ovarian cancer. Postoperative FACT-G scores were significantly lower (p=0.015). A clinically relevant postoperative decrease in quality of life was identified in 51 patients (41.5%). Independent predictors of deteriorated postoperative QoL in this study were: advanced disease stage, extensive surgical resection, comorbidities and higher education. Conclusion: The results illustrate the physical, psychological, and social effects of the surgical treatment on the early postoperative QoL, thereby emphasizing the need for a comprehensive, multidisciplinary approach to the pre and postoperative care of these patients. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of the value of p53 protein expression in the extra-capsular extension of prostate cancer(2011); ;Georgiev, V; ;Penev, MThe objective of this study is to identify the nuclear expression of the p53 protein in prostate cancer and to determine its relationship with clinico-pathological variables. - Some of the metrics are blocked by yourconsent settings
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Item type:Publication, Character and Temperament Dimensions in Subjects with Depressive Disorder: Impact of the Affective State on Their Expression(Scientific Foundation SPIROSKI, 2017-03-15); ;Novotni, A; ; The depression is a cross-cultural condition that occurs in all cultures and within all nations with certain specificities, even though there are some differences in its manifestation. The hereditary load is of major importance, but also the individual personality factors, in the form of risk factors, are associated with the occurrence of depression. Personality characteristics have a significant impact on the occurrence of the recurrent depressive disorder and the outcome of the treatment as well. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparative analysis of orthodontically indicated labial frenectomy with conventional surgery and diode laser(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2018); ;Milevski M ;Dzipunova B; Radojkova -Nikolovska V - Some of the metrics are blocked by yourconsent settings
Item type:Publication, COMPARISON OF TWO DIFFERENT PLATE TYPES IN THE MINIMALLY INVASIVE PERCUTANEOUS PLATE OSTEOSYNTHESIS OF DISTAL TIBIA FRACTURES(Macedonian Association of Anatomists and Morphologists, 2023) ;Nastov, Nebojsha ;Bekteshi, Labinot; ; Distal tibia fractures present a unique challenge for the surgeon due to the subcutaneous position of the tibia with a thin soft tissue envelope. The development of the technique for minimally invasive percutaneous plate osteosynthesis (MIPPO) is a well-accepted step towards this direction. In our study we explore the benefits and shortcomings of two different plate types used with this technique: the 3.5 mm anatomically pre-shaped titanium plate, and the 4.5 mm LC-DCP. The study was a prospective – retrospective clinical intervention case control study of 100 patients with closed, unstable, extraarticular and partially articular fractures of the distal tibia and fibula, classified as AO type 43A1, 43A2 and 43А3. Patients were divided in two groups of 50 patients. Group A were patients prospectively treated with a 3.5 mm pre-shaped plate, and Group B were patients with retrospectively collected data treated with a 4.5 mm LC-DCP. Patietns age was 38.15 years with 68 male and 32 female patients. Operation duration in Group A was 57.14 ± 8.30 and 66.67 ± 5.55, in Group B which was statistically significant. Partial and full weight bearing, as well as time to union in both groups was achieved within a similar timeframe. Functional according to Johner and Wruh's criteria and showed that most patients in both groups (61) had excellent results (Group A: 32, Group B: 29) and 21 had good results (Group A: 10, Group B:11). Rate of complications were comparable between the two groups, in regard to superficial infection, deep infection and ankle stiffness. Only complication parameter which showed a significant difference between the two groups was rate of implant irritation, which was higher in the 4.5 mm LC-DCP group. Both 3.5 mm and 4.5 mm plates are reliable when used with a MIPPO technique. This method is minimally invasive, preserves the periosteal blood supply and ensures optimal conditions for biological repair of distal tibia fractures, regardless of the type of plate used. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluation of Total Thyroidectomy for Treatment of Benign Diseases of Thyroid Gland(Scientific foundation SPIROSKI, 2020-04-25); ;Tolevska, Natasha ;Qafjani, Ardit; BACKGROUND: The controversy of using total thyroidectomy (TT) in treatment of benign thyroid diseases still remains controversial over the rates of complication, mostly recurrence nerve palsy and hypocalcemia, compared to non-total thyroidectomies. The latest reports in this field of research showed that that the number of complications of TT is decreasing as the skills of surgeons increase. AIM: In this study, we reviewed 209 cases of total thyroidectomies for benign thyroid diseases where such surgery was indicated. The results were evaluated whether they support the previous reports that TT is save method of treatment of diffuse multinodular goiters, Graves’ disease thyroid adenomas with diffuse goiters and thyroiditis. METHODS: Two hundred and nine patients, 36 males and 173 females, medium age 47 (17–77) operated with TT between 2016 and 2018 were included in the evaluation study. We evaluated the: Diagnosis, indications for operation, pre-operative medication administration, laryngeal recurrent nerve palsy, hypocalcemia, hypoparathyroidism, and patohistology findings. The follow-up for hypocalcemia and laryngeal nerve palsy was performed 1 year postoperatively. RESULTS: The age of the patients was between 17 and 77 years, medium-range 47 years old. Of 209 patients, 173 (83%) were female and 36 (17%) male with a gender ratio of 1:4.8 males to females. Diagnoses before surgery were established as follows: Multinodular euthyroid goiter (MNEG) n = 106 (48.80%), multinodular toxic goiter n = 12 (5.74%), Graves’s disease n = 6 (2.87%), adenoma with multinodular goiter n = 73 (34.92%), and n = 16 (7.65%) patients with thyroiditis. Recurrence laryngeal nerve palsy (RLNP) occurred in 6 patients (2.87%), temporary within 3 months after the operation in 4 patients (1.92%) and permanent palsy within 6 months and more after an operation in 2 patients (0.95%). Voice hoarseness immediately and within 1 month after the operation was registered in 32 patients (15.3%). RLNP and hoarseness were registered mostly in patients with pre-operative problems, mostly with extra big MNEG. One of the permanent injuries of RLN was bilateral and all others were one sided. All patients were operated with normal pre-operative vocal cord movement findings. Post-operative hypocalcemia was registered in 35 patients (16.74%). Temporary nonsignificant hypocalcemia in 10 (4.78%), temporary significant hypocalcemia in 17 (8.13%), temporary severe hypocalcemia in 6 patients (2.87%), and permanent hypocalcemia in 2 patients (0.95%). CONCLUSION: Many studies have shown that the rate of complications is almost even for TT and NTT done for benign and malignant diseases of thyroid gland. Our data have shown that the risk of post-operative complications with TT is proportional to the number of complicated pre-operative findings of benign thyroid glands. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, МАКРОЕКОНОМСКИТЕ ЕФЕКТИ НА ФИСКАЛНАТА ПОЛИТИКА ВО РЕПУБЛИКА МАКЕДОНИЈА(Македонска Академија на Науките и Уметностите, 2017); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessment of mineralization of oral surgical defects in patients with diabetes mellitus according to Hba1C(Medical faculty, Ss Cyril and Methodius University in Skopje, 2018-11); ; ;Veleska Stevkova, D; Pisevska Cholakova, N - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Topical Imiquimod 5% as a Treatment Option in Solitary Facial Keratoacanthoma(ID Design 2012/Scientific Foundation SPIROSKI, 2018-03-15); ;Pepic, Senada ;Idoska, Sanela; Keratoacanthoma (KA) is a rapidly growing epithelial tumour with histopathologic and clinical features similar to squamous cell carcinoma (SCC) and a certain tendency toward spontaneous regression.
