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http://hdl.handle.net/20.500.12188/34133| Title: | DETECTION OF JAK2 V617F MUTATION IN A PATIENT WITH C-KIT POSITIVE GASTROINTESTINAL STROMAL TUMOR: CASE REPORT | Authors: | Trajkova, Sanja Krstevska Balkanov, Svetlana Pivkova Veljanovska, Aleksandra Lichoska Josifovikj, Fana Popova Labachevska, Marija Ridova, Nevenka Stojanovska Jakimovska, Simona Cvetanovski, Milche Kochoski, Bozhidar Paunovska, Andrea Stojanovski, Martin Purde, Merve Panovska Stavridis, Irina |
Issue Date: | 2-May-2025 | Publisher: | Macedonian Association of Anatomists | Journal: | Journal of Morphological Sciences | Abstract: | <jats:p>C-Kit is receptor tyrosine kinase which is involved in various signaling pathways and has been recognized in pathogenesis of several types of cancers including gastrointestinal stromal tumor (GIST). More than 50 years, scientist have been studied GIST and made advances in treatment based on c-Kit inhibition. One of the signaling pathway involving activation via c-Kit is the JAK/STAT pathway located on hematopoietic cells resulting activation of transcription of a variety of genes. Here, we provide a case report of patient with two malignancy c-Kit positive GIST and Essential Thrombocytemia (ET) positive for JAK2 V617F mutation.</jats:p> | URI: | http://hdl.handle.net/20.500.12188/34133 | DOI: | 10.55302/jms2581193t |
| Appears in Collections: | Faculty of Medicine: Journal Articles |
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| File | Size | Format | |
|---|---|---|---|
| DETECTION OF JAK2 V617F MUTATION IN A PATIENT WITH C-KIT POSITIVE.pdf | 161.19 kB | Adobe PDF | View/Open |
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