BRIEF REVIEW OF THE THROMBOTIC CEREBROVASCULAR COMPLICATIONS ASSOCIATED WITH NONSTEROID ANTI-INFLAMMATORY DRUGS IN PATIENTS WITH CEREBROVASCULAR DISEASES

Abstract

Introduction. The use of the commonly used non-steroid anti-inflammatory medications can lead to specific complications in patients with cerebrovascular conditions. Their safety profile can be associated with both hemorrhagic and thrombotic complications, which can exert untoward influence in these patients. The aim of the present text is to 1) meaningfully recapture the main literature findings on the thrombotic complications due to use of NSAIDs in these patients and to 2) provide aid for physicians that encounter such decisions. Inhibition of the cyclo-oxygenase as main effect. The use of these medications rely on a common mechanism that inhibits a specific set of enzymes called cyclooxygenase inhibitors. Here, we revisit the specific cascade that enables their effect and the important interplay that may occur in patients with cerebrovascular diseases, including medications that exert unspecific vs targeted inhibition of those specific enzymes. Conclusion. The use of particular NSAIDs have been evaluated in patients with cerebrovascular diseases, and their specific risk for thrombotic complications in these patients have been examined in wide collection of patients. So far, these evaluations emphasize the association between the duration of use and type of selectivity of a particular NSAID and its risk for further thrombotic complications.