Electrochemical detection and evaluation of diclofenac chloride with modified screen-printed electrodes

Abstract

drugs including the anti-inflammatory drugs (AIDs) in the waters became very important. Electrochemical methods offer an acceptable level of detection providing low-cost, reagent-consuming and fast analysis. So, in this study, a Cyclic Voltammetry (CV) was discussed in detail, along with scanning electron microscopy (SEM) and atomic force microscopy (AFM), as analytical characterization techniques. Screen-printed electrodes (SPE) based on carbon nanotubes (CNTs) were explored as a biosensors for ultrasensitive detection of biochemical entities, such as active pharmaceutical ingredient (API) – Diclofenac chloride (DIC). Surface modification of the SPEs was done using Polyvinylidene fluoride (PVDF), applied with drop modification method. Physical characterization made with SEM and AFM has found the surface morphology and grain topography of the working electrodes as well as the roughness changes. Results obtained with the electrochemical analysis show that the acidic environment contributes for better redox processes hence modifications with PVDF show better electrochemical response at low pH. In terms of redox processes and pH influence, diclofenac shows strong electrochemical response.