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http://hdl.handle.net/20.500.12188/30585
Title: | Postpartum decline in sflt-1/plgf ratio confirms placental source of angiogenic imbalance and endothelial dysfunction in preeclampsia | Authors: | Samardjiski, Igor Simeonova Krstevska, Slagjana Livrinova, Vesna Todorovska, Irena Paneva, I. Joksimovich, Marija Atanasova Boshku, Aleksandra |
Issue Date: | Feb-2024 | Publisher: | Elsevier BV | Journal: | European Journal of Obstetrics & Gynecology and Reproductive Biology | Abstract: | Preeclampsia (PE) is a multisystem disorder in pregnancy with a specific collection of signs and symptoms as a result of serious dysfunction of multiple organs. Abnormal placentation in the first trimester, most likely triggers the disbalance of the placental anti-angiogenic factor soluble fms-like tyrosine kinase-1(sFlt-1) and pro-angiogenic placental growth factor (PlGF), which result in systemic endothelial dysfunction (injury) to progressive end-organ damage. According the PROGNOSIS study, the cut-off value of the sFlt-1/PlGF ratio over 85 confirms the suspected PE and proved to be useful in preeclampsia diagnosis. A severely elevated sFlt-1/PlGF ratio is associated closely with the need to deliver within 48hours. | URI: | http://hdl.handle.net/20.500.12188/30585 | DOI: | 10.1016/j.ejogrb.2023.08.029 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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