Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/28815
Title: Comparison of Oxidative Stress Levels in Healthy Children and Children with Allergic Rhinitis
Authors: Arnaudova Danevska, Ivana 
Jakjovska, Tatjana 
Zendelovska, Dragica 
Atanasovska, Emilija 
Dzekova Vidimliski, Pavlina 
Petrushevska, Marija 
Boshkovska, Katerina 
Popova, Gorica
Tasevska, Elena Gjinovska
Balkanov, Trajan 
Issue Date: 1-Mar-2023
Publisher: Walter de Gruyter GmbH
Journal: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) 
Abstract: Background/aim: Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa. Under the influence of exogenous factors - allergens, reactive oxygen species (ROS) are released during cellular metabolism. They induce a series of pathological changes in the mucosa. Oxidative stress is а result of an imbalance between the production of ROS and the ability to neutralize them. The aim of this study is to compare the levels of oxidative stress between healthy children and children with allergic rhinitis. Material and methods: A total number of 60 children were included (30 healthy children and 30 children with AR). The oxidative stress index was determined by using the FRAS 5 (Free Radical Analytical System) Bravo system. Demographic characteristics, medical history, children's living conditions and eating habits were obtained from the questionnaire. Anthropometric measurements and the absolute number of eosinophils in the peripheral smear were performed on each child. Results: This study showed high oxidative stress index and a significantly higher value of the absolute number of eosinophils in the peripheral smear in children with AR in comparison to healthy children (p<0.05). The group of children with AR had more atopic characteristics and was more exposed to passive smoking than healthy children. Conclusion: Compared to healthy children, children with AR have a high index of oxidative stress, despite of the very high mean value of the concentration of water-soluble antioxidants in serum (PAT test) in the group of children with AR.
URI: http://hdl.handle.net/20.500.12188/28815
DOI: 10.2478/prilozi-2023-0003
Appears in Collections:Faculty of Medicine: Journal Articles

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