Induction of hypothyroidism in albino wistar rats-expire mental animal model

Abstract

Introduction: Altered thyroid function (hypothyroidism / hyperthyroidism) can be considered as a frequent and common medical issue. Due to metabolic changes, almost all systems and functional processes in the human body are. Experimental animal models of thyroid dysfunc- tion are the key for further scientific investigations of the peripheral effects of thyroid hormones at cellular and sub cellular level. Aim: To establish an experimental animal model of impaired function of the thyroid gland – hypothyroidism. Matherials and methods: 20 Wistar rats (10 males - 350 ± 40 gr and 10 females - 320 ± 40 gr), average age 7 months old, were analyzed in the period of 2 months (treated for 1 month with Propilthiouracil 1 mg/100g body mass in drinking water and 1 following month without treatment). The following basic parameters were determined for each subject (body mass index, temperature, thyroid status). The second group of 10 Wistar rats - (5 males and 5 females) did not recieve Propilthiouracil and this was the control group used to obtain normal morphomet- ric and biochemical parameters. Results: Between the mean values of FT4 and FT3 at the beginning, at the intersection and at the end of the study, there were statistically significant differences with decreased levels at the cross section and no statistically significant difference between the beginning and the end of the examination in the group treated with Propiltiouracil. No statistically significant differences were detected in the control group. Conclusion: Experimental animal model of impaired function of the thyroid gland – hypothy- roidism in Wistar rats was successfully established.