Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/24738
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dc.contributor.authorIvana Mitrevska,en_US
dc.contributor.authorHristijan Mickoski,en_US
dc.contributor.authorKaterina Brezovska,en_US
dc.contributor.authorAneta Dimitrovska,en_US
dc.date.accessioned2022-12-05T16:55:51Z-
dc.date.available2022-12-05T16:55:51Z-
dc.date.issued2021-04-30-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/24738-
dc.description.abstractThe aim of this study was to compare the in vitro dissolution behaviour of reference (R) and generic-test (T) medicinal products with non-linear effects model. Mathematical function Weibull, was employed as basis for the non-linear effects model, coupled with MATLABTM simulation software to describe the release profile of the active substance. Medicinal products selected for the presented study include immediate-release tablets Concor 10 mg and Bisoprolol 10 mg, which belongs to BCS class 1 of biopharmaceutics classification system. The result from the study indicated that Weibull distribution function coupled with computer-based program is more useful for comparison of the dissolution profiles. This combined approach provides robust and informative results, with accurate estimation on the in vitro performance for the medicinal products and it’s the most suitable tool for prediction of in vivo behaviour of the medicinal product. In summary, we have employed Simulink graphical programming to design our system in a simulation environment.</jats:p>en_US
dc.language.isoenen_US
dc.publisherGSC Online Pressen_US
dc.relation.ispartofWorld Journal of Advanced Research and Reviewsen_US
dc.titleEvaluation of in vitro dissolution similarity of bisoprolol film-coated tablets based on Weibull modelling using MATLABTM simulation softwareen_US
dc.typeArticleen_US
dc.identifier.doi10.30574/wjarr.2021.10.1.0143-
dc.identifier.urlhttps://wjarr.com/content/evaluation-vitro-dissolution-similarity-bisoprolol-film-coated-tablets-based-weibull-
dc.identifier.volume10-
dc.identifier.issue1-
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:Faculty of Pharmacy: Journal Articles
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