Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/19128
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Russo, Manuela | en_US |
dc.contributor.author | Repisti Selman | en_US |
dc.contributor.author | Blazhevska Stoilkovska, Biljana | en_US |
dc.contributor.author | Jerotic, Stefan | en_US |
dc.contributor.author | Ristic, Ivan | en_US |
dc.contributor.author | Mesevic Smajic, Eldina | en_US |
dc.contributor.author | Uka, Fitim | en_US |
dc.contributor.author | Arenliu, Aliriza | en_US |
dc.contributor.author | Bajraktarov, Stojan | en_US |
dc.contributor.author | Dzubur Kulenovic, Almai | en_US |
dc.contributor.author | Injac Stevovic, Lidija | en_US |
dc.contributor.author | Priebe Stefan | en_US |
dc.contributor.author | Jovanovic, Nikolina | en_US |
dc.date.accessioned | 2022-06-22T15:21:44Z | - |
dc.date.available | 2022-06-22T15:21:44Z | - |
dc.date.issued | 2021-12-14 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/19128 | - |
dc.description.abstract | Background: Negative symptoms are core features of schizophrenia and very challenging to be treated. Identification of their structure is crucial to provide a better treatment. Increasing evidence supports the superiority of a five-factor model (alogia, blunted affect, anhedonia, avolition, and asociality as defined by the NMIH-MATRICS Consensus); however, previous data primarily used the Brief Negative Symptoms Scale (BNSS). This study, including a calibration and a cross-validation sample (n = 268 and 257, respectively) of participants with schizophrenia, used the Clinical Assessment Interview for Negative Symptoms (CAINS) to explore the latent structure of negative symptoms and to test theoretical and data-driven (from this study) models of negative symptoms. Methods: Exploratory factor analysis (EFA) was carried out to investigate the structure of negative symptoms based on the CAINS. Confirmatory factor analysis (CFA) tested in a cross-validation sample four competing theoretical (one-factor, two-factor, five-factor, and hierarchical factor) models and two EFA-derived models. Result: None of the theoretical models was confirmed with the CFA. A CAINS-rated model from EFA consisting of five factors (expression, motivation for recreational activities, social activities, vocational, and close/intimate relationships) was an excellent fit to the data (comparative fix index = 0.97, Tucker–Lewis index = 0.96, and root mean square error of approximation = 0.07). Conclusions: This study cannot support recent data on the superiority of the five-factor model defined by the NMIH-MATRICS consensus and suggests that an alternativemodel might be a better fit. More research to confirm the structure of negative symptoms in schizophrenia, and careful methodological consideration, should be warranted before a definitive model can put forward and shape diagnosis and treatment of schizophrenia. | en_US |
dc.description.sponsorship | This study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 779334. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers | en_US |
dc.relation.ispartof | Frontiers in Psychiatry | en_US |
dc.subject | negative symptoms, confirmatory factor analysis, CAINS, BNSS, five-factor model, schizophrenia | en_US |
dc.title | Structure of Negative Symptoms in Schizophrenia: An Unresolved Issue | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | doi: 10.3389/fpsyt.2021.785144 | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Philosophy | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Philosophy 04: Journal Articles / Статии во научни списанија |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fpsyt-12-785144 (1).pdf | 208.11 kB | Adobe PDF | View/Open |
Page view(s)
72
checked on Sep 17, 2024
Download(s)
10
checked on Sep 17, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.