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http://hdl.handle.net/20.500.12188/1770| Title: | Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia | Authors: | Laurenti, Luca Petlickovski, Aleksandar Rumi, Carlo Gobessi, Stefania Piccioni, Paola Tarnani, Michela Puggioni, Pierluigi Marietti, Sara Sica, Simona Leone, Giuseppe Efremov, Dimitar G |
Issue Date: | Nov-2005 | Journal: | Haematologica | Abstract: | The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard. | URI: | http://hdl.handle.net/20.500.12188/1770 |
| Appears in Collections: | Faculty of Medicine: Journal Articles |
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