Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/16146
DC Field | Value | Language |
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dc.contributor.author | Breznica-Selmani, Pranvera | en_US |
dc.contributor.author | Mladenovska, Kristina | en_US |
dc.contributor.author | Dräger, Gerald | en_US |
dc.contributor.author | Mikhova, Bozhana | en_US |
dc.contributor.author | Panovski, Nikola | en_US |
dc.contributor.author | Kaftandzieva, Ana | en_US |
dc.contributor.author | Kavrakovski, Zoran | en_US |
dc.contributor.author | Hoxha, Ahmet | en_US |
dc.contributor.author | Sheqerxhiu, Nardi | en_US |
dc.contributor.author | Jurhar Pavlova, Maja | en_US |
dc.contributor.author | Popovski, Emil | en_US |
dc.date.accessioned | 2022-01-14T09:02:46Z | - |
dc.date.available | 2022-01-14T09:02:46Z | - |
dc.date.issued | 2016-10-12 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/16146 | - |
dc.description.abstract | <jats:p>Herein we report the synthesis of different derivatives of (fluoro)quinolones norfloxacin, ciprofloxacin and pipemidic acid, by incorporating (benzoylamino)methyl on the free nitrogen of the pyperazinyl moiety. The compounds were structurally characterized by 1D and 2D NMR, FTIR and high-resolution mass spectroscopy. In addition, their physicochemical properties were a matter of interest to be correlated with their structure and antimicrobial activity<em> in vitro</em>. Their antimicrobial activities were screened against Gram-positive, Gram-negative bacteria and <em>C. albicans</em>. Higher distribution coefficients and consequently lower water solubility were determined for all synthesized compounds than the ones of the corresponding leading compounds. Inconsequential correlations between the lipophilicity of the compounds and MIC were observed, suggesting that passive diffusion is not the only mechanism for their penetration into bacterial cells. Further studies are needed to determine how substitutions in the (fluoro)quinolone moiety affect the primary target(s), substrate behavior in respect to bacterial transporters and overall bioavailability.</jats:p> | en_US |
dc.publisher | Society of Chemists and Technologists of Macedonia | en_US |
dc.relation.ispartof | Macedonian Journal of Chemistry and Chemical Engineering | en_US |
dc.title | Synthesis, physicochemical characterization and antibacterial activity of novel (benzoylamino)methyl derivatives of quinolones | en_US |
dc.identifier.doi | 10.20450/mjcce.2016.919 | - |
dc.identifier.url | http://www.mjcce.org.mk/index.php/MJCCE/article/viewFile/919/528 | - |
dc.identifier.url | http://www.mjcce.org.mk/index.php/MJCCE/article/viewFile/919/528 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 2 | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Faculty of Natural Sciences and Mathematics | - |
crisitem.author.dept | Faculty of Pharmacy | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Pharmacy | - |
Appears in Collections: | Faculty of Natural Sciences and Mathematics: Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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XIII_2139.pdf | P. Breznica-Selmani, K. Mladenovska, G. Dräger, B. Mikhova, N. Panovski, A. Kaftandzieva, Z. Kavrakovski, A. Hoxha, N. Sheqerxhiu, M. J. Pavlova, E. Popovski, Synthesis, physicochemical characterization and antibacterial activity of novel (benzoylamino)methyl derivatives of quinolones, Macedonian Journal of Chemistry and Chemical Engineering, 35(2) 179–197 (2016). | 1.31 MB | Adobe PDF | View/Open |
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