Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/16146
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dc.contributor.authorBreznica-Selmani, Pranveraen_US
dc.contributor.authorMladenovska, Kristinaen_US
dc.contributor.authorDräger, Geralden_US
dc.contributor.authorMikhova, Bozhanaen_US
dc.contributor.authorPanovski, Nikolaen_US
dc.contributor.authorKaftandzieva, Anaen_US
dc.contributor.authorKavrakovski, Zoranen_US
dc.contributor.authorHoxha, Ahmeten_US
dc.contributor.authorSheqerxhiu, Nardien_US
dc.contributor.authorJurhar Pavlova, Majaen_US
dc.contributor.authorPopovski, Emilen_US
dc.date.accessioned2022-01-14T09:02:46Z-
dc.date.available2022-01-14T09:02:46Z-
dc.date.issued2016-10-12-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/16146-
dc.description.abstract<jats:p>Herein we report the synthesis of different derivatives of (fluoro)quinolones norfloxacin, ciprofloxacin and pipemidic acid, by incorporating (benzoylamino)methyl on the free nitrogen of the pyperazinyl moiety. The compounds were structurally characterized by 1D and 2D NMR, FTIR and high-resolution mass spectroscopy. In addition, their physicochemical properties were a matter of interest to be correlated with their structure and antimicrobial activity<em> in vitro</em>. Their antimicrobial activities were screened against Gram-positive, Gram-negative bacteria and <em>C. albicans</em>. Higher distribution coefficients and consequently lower water solubility were determined for all synthesized compounds than the ones of the corresponding leading compounds. Inconsequential correlations between the lipophilicity of the compounds and MIC were observed, suggesting that passive diffusion is not the only mechanism for their penetration into bacterial cells. Further studies are needed to determine how substitutions in the (fluoro)quinolone moiety affect the primary target(s), substrate behavior in respect to bacterial transporters and overall bioavailability.</jats:p>en_US
dc.publisherSociety of Chemists and Technologists of Macedoniaen_US
dc.relation.ispartofMacedonian Journal of Chemistry and Chemical Engineeringen_US
dc.titleSynthesis, physicochemical characterization and antibacterial activity of novel (benzoylamino)methyl derivatives of quinolonesen_US
dc.identifier.doi10.20450/mjcce.2016.919-
dc.identifier.urlhttp://www.mjcce.org.mk/index.php/MJCCE/article/viewFile/919/528-
dc.identifier.urlhttp://www.mjcce.org.mk/index.php/MJCCE/article/viewFile/919/528-
dc.identifier.volume35-
dc.identifier.issue2-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptFaculty of Natural Sciences and Mathematics-
crisitem.author.deptFaculty of Pharmacy-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Pharmacy-
Appears in Collections:Faculty of Natural Sciences and Mathematics: Journal Articles
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XIII_2139.pdfP. Breznica-Selmani, K. Mladenovska, G. Dräger, B. Mikhova, N. Panovski, A. Kaftandzieva, Z. Kavrakovski, A. Hoxha, N. Sheqerxhiu, M. J. Pavlova, E. Popovski, Synthesis, physicochemical characterization and antibacterial activity of novel (benzoylamino)methyl derivatives of quinolones, Macedonian Journal of Chemistry and Chemical Engineering, 35(2) 179–197 (2016).1.31 MBAdobe PDFView/Open
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