Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/14237
Title: The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Authors: Geskovski, Nikola
Matevska-Geshkovska, Nadica
Dimchevska Sazdovska, Simona
Glavas Dodov, Marija
Mladenovska, Kristina 
Goracinova, Katerina
Keywords: CD44
EGFR
liquid tumors
molecular tumor targeting
myeloid leukemia
solid tumors
surface-engineered nanoparticles
Issue Date: 29-Apr-2021
Publisher: Beilstein Institut
Journal: Beilstein journal of nanotechnology
Abstract: Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, which create a great amount of data related to the unique molecular signatures of each tumor subtype, have emerged as an important tool for detailed profiling of tumors. They provide an opportunity to develop targeting agents for early detection and diagnosis, and to select the most effective combinatorial treatment options. Alongside, the design of the nanoscale carriers needs to cope with novel trends of molecular screening. Also, multiple targeting ligands needed for robust and specific interactions with the targeted cell populations have to be introduced, which should result in substantial improvements in safety and efficacy of the cancer treatment. This article will focus on novel design strategies for nanoscale drug delivery systems, based on the unique molecular signatures of myeloid leukemia and EGFR/CD44-positive solid tumors, and the impact of novel discoveries in molecular tumor profiles on future chemotherapeutic protocols.
URI: http://hdl.handle.net/20.500.12188/14237
ISSN: 2190-4286
DOI: 10.3762/bjnano.12.31
Appears in Collections:Faculty of Pharmacy: Journal Articles

Files in This Item:
File Description SizeFormat 
Geskovski et al. BJNano 2021.pdf1.85 MBAdobe PDFView/Open
Show full item record

Page view(s)

51
checked on Jun 27, 2022

Download(s)

7
checked on Jun 27, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.