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Наслов: Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation
Authors: Starzl, T E
Demetris, A J
Trucco, M
Zeevi, A
Ramos, H
Terasaki, P
Rudert, W A
Kocova, M 
Ricordi, C
Ildstad, S
Issue Date: јун-1993
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Journal: Transplantation
Abstract: Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n = 2) or modest (n = 2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance).
URI: http://hdl.handle.net/20.500.12188/11562
ISSN: 0041-1337
DOI: 10.1097/00007890-199306000-00012
Appears in Collections:Faculty of Medicine: Journal Articles

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