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http://hdl.handle.net/20.500.12188/11562
Наслов: | Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation | Authors: | Starzl, T E Demetris, A J Trucco, M Zeevi, A Ramos, H Terasaki, P Rudert, W A Kocova, M Ricordi, C Ildstad, S |
Issue Date: | јун-1993 | Publisher: | LIPPINCOTT WILLIAMS & WILKINS | Journal: | Transplantation | Abstract: | Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n = 2) or modest (n = 2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance). | URI: | http://hdl.handle.net/20.500.12188/11562 | ISSN: | 0041-1337 | DOI: | 10.1097/00007890-199306000-00012 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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