DIAGNOSING ABDOMINAL OBESITY IN WOMEN WITH CUT – OFF POINT VALUES OF THE ESTIMATED CENTRAL OBESITY INDEX DETERMINED WITH DUAL-ENERGY X-RAY ABSORPTIOMETRY

Abstract

Introduction: Dual-energy X-ray absorptiometric (DXA), central obesity index (COI) and estimated COI (eCOI) are useful diagnostic DXA test procedures of extreme central, abdominal obesity in Cushing’s syndrome (CS) and non CS abdominally obese women, and determination of their diagnostic cut-off point values (CPV) is very important. Materials and methods: COI and eCOI values were determined in 3 groups, each consisting of 18 women: 1st group of CS, 2nd group of obese women (O) not different according to their age and Body Mass Index (BMI) with CS and 3rd group of non-obese healthy women (C) with normal BMI. COI1 and eCOI1 CPV were used to best differentiate CS and O. COI2 and eCOI2 CPV were used to best differentiate CS and O with C. Their diagnostic accuracy (DG), sensitivity (S) and specificity (SP) were determined. Results: COI and eCOI values were significantly different among the 3 groups. COI1 CPV of 0.9 best differentiated CS from O with DG of 70% and sensitivity of 90% but eCOI1 CPV of 0.92 differentiated them with DG of 75% and S of 100%. COI2 CPV of 0.82 best differentiated C from O with DG of 82.14% and SP of 88.89% as well as eCOI2 CPV of 0.84 differentiated them for DG of 75% and SP of 80%. COI2 CPV of 0.82 and eCOI2 0.84 best differentiated CS from C in both cases for DG of 92.86% and SP of 88.89%. Conclusion: Cut-off point values of COI1 and COI2 as well as eCOI1 and eCOI2 are very important diagnostic test procedures in discovering abdominal and normal body fat distribution. Determined eCOI1 and eCOI2 cut-off point values are especially very useful diagnostic screening tests of body fat distribution in everyday routine clinical praxis during spine and hip bone mineral content assessment.