Splenic Pigmented Macrophage Aggregates in Barbel (Barbus peloponnesius, Valenciennes, 1844) from River Bregalnica — Influences of Age, Sex and Season on a Pollution Biomarker

Journal
Turkish Journal of Fisheries and Aquatic Sciences
Date Issued
2016
Author(s)
Maja Jordanova, Katerina Rebok, Marija Naskovska, Vasil Kostov, Eduardo Rocha
DOI
DOI: 10.4194/1303-2712-v16_4_15
Abstract
Macrophages are involved in innate and acquired immune responses, being key players in immunotoxicology. Changes
in the quantities of pigmented macrophage aggregates (PMQ) in fish are often used as biomarkers of pollution. Most studies
offer only qualitative data on PMQ changes, and effects of age, sex and season are poorly known. We present a stereological
study of the relative and total volumes of PMQ in the barbel, Barbus peloponnesius spleen. Our focus is to disclose influences
of age, sex and season on PMQ, and check if the there is any positive association with aging. The females had a significantly
higher spleen and body weights and length. PMQ loaded with lipofuscin/ceroid and hemosiderin were dispersed throughout
both spleen pulps. Seasons impacted on PMQ, despite no too markedly. Differences existed between sexes, with males having
significantly higher relative volumes of PMQ: the total volumes had similar tendencies. The volumes of PMQ were positively
associated with age. The new data reinforce the importance of studying influences of both intrinsic and extrinsic factors that
model the quantities of PMQ so to better interpret their changes seen in biomonitoring works
Subjects

Barbel, melanomacroph...

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