Higher Plasma Cocentration of Food-Specific Antibodies in Persons with Autistic Disorder in Comparison to Their Siblings
Journal
Focus on Autism and Other Developmental Disabilities
Date Issued
2008
Author(s)
Efinska-Mladenovska, Olivija
Arsov, Todor
Strezova, Ana
Ajdinski, Ljupcho
DOI
10.1177/1088357608320413
Abstract
Specific IgA, IgG, and IgE antibodies to food antigens in 35 participants with autistic disorder and 21 of their siblings in the Republic of Macedonia were examined. Statistically significant higher plasma concentration of IgA antibodies against alpha-lactalbumin, beta-lactoglobulin, casein, and gliadin were found in the children with autistic disorder. Plasma concentrations of IgG antibodies against alpha-lactalbumin, beta-lactoglobulin, and casein in participants with autistic disorder were significantly higher. IgE-specific antibodies (alpha-lactalbumin, beta-lactoglobulin, casein, and gluten), as well as plasma concentration of total IgE, also were statistically significantly higher in the participants with autistic disorder. Gender differences were found for select IgA, IgG, and IgE (but not for total IgE) food-specific antibodies (kU/L) in the participants with autistic disorder and their siblings.
Subjects
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