Is there an association between paternal age and aneuploidy? Evidence from young donor oocyte-derived embryos: a systematic review and individual patient data meta-analysis
Journal
Human Reproduction Update
Date Issued
2021-05
Author(s)
Dviri, Michal
Madjunkova, Svetlana
Koziarz, Alex
Madjunkov, Mitko
Mashiach, Jordana
Nekolaichuk, Erica
Al-Asmar, Nasser
Moskovtsev, Sergey Ivanovovich
Librach, Clifford
DOI
10.1093/humupd/dmaa052
Abstract
Delayed parenthood, by both women and men, has become more common in developed countries. The adverse effect of advanced maternal age on embryo aneuploidy and reproductive outcomes is well known. However, whether there is an association between paternal age (PA) and embryonic chromosomal aberrations remains controversial. Oocyte donation (OD) is often utilized to minimize maternal age effects on oocyte and embryo aneuploidy, thus providing an optimal model to assess the effect of PA. Several studies have revealed a higher than expected rate of aneuploidy in embryos derived from young oocyte donors, which warrants examination as to whether this may be attributed to advanced PA (APA).
Subjects