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    Chlamydia pneumoniae and helicobacter pylori serology - importance in patients with coronary heart disease
    (Academy of Medical Sciences of Bosnia and Herzegovina, 2012)
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    Zafirovska, Planinka
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    Jaglikovski, Branko
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    Chronic infections in CHD are due to one or both of the organisms Chlamydia pneumoniae and Helicobacter pylori.
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    Epidemiological Characteristics of Great Depression diseases of hospitalized patients in psychiatric hospital Skopje for a five year period from 2013 to 2017
    (2021)
    Iliev, Biljana
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    Депресијата е честа и истоштувачка болест која ги погодува луѓето од адолесценцијата до староста и има изразено негативно влијание на менталното и физичкото здравје, како и врз социјалната и финансиската благосостојба на поединецот и општеството. Депресијата често е недоволно дијагностицирана, недоволно лечена и поврзана со негативен исход. Познавањето на епидемиолошките карактеристики на депресијата е од големо значење за планирањето на соодветниот третман на депресијата, нејзино навремено откривање и лекување со цел намалување на далекусежните последици на индивидуален и општествен план. Со оглед дека во нашата земја недостасуваат епидемиолошки податоци за депресијата истражувањето ја испитува болничката преваленца на депресијата во трите психијатриски болници во Македонија, социодемографските карактеристики во однос на половите специфики на заболените, како и должината и зачестеноста на хоспитализациите, суицидалноста и коморбидитетот во однос на половите специфики. Податоците се собрани од историите на болест на болнички лекуваните депресии во трите болници во периодот 2014-2017 год со дијагноза депресија (Ф32.0 - Ф32.3) исклучувајќи ги оние со биполарно нарушување. Резултатите упатуваат на ненавремност во дијагностицирањето, касен почеток на лекувањето кој доминантно се сведува на хоспитален третман без пред и постхоспитално следење на пациентите со депресија. Ваквите наоди ја нагласуваат потребата од неопходност од справување со стигмата која депресијата ја носи со себе и развивање на сеопфатен систем за рано дијагностицицирање, третман и следење на ова растројство особено во однос на половите специфики.
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    Risk for Occurrence of Laryngeal Cancer Among Current Cigarette Smokers
    (American Society of Clinical Oncology (ASCO), 2018-10-01)
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    <jats:p> Background: Cancer is a leading cause of death worldwide. It is on the second place as a death cause in developed countries and among the three leading death causes in adults in developing countries. Every year, worldwide, approximately 10 million persons have been diagnosed with malignant tumors (in every locations), and more than 6 million of these people die. According to many studies, several risk factors are brought in connection with laryngeal cancer (LarC). The most significant and generally accepted is alcohol consumption and the habit of cigarette smoking. Cigarette smoking habit caused about 30% of all cancers, due to which it represents the most significant risk factor for occurrence of these disorders in humans. Aim: Aim of the study was to determine the existence of the eventual causal associations among the cigarette smoking and development and distribution of the laryngeal cancer. Methods: This study is an analytical type of case-control study. It elaborated 185 patients, suffering from laryngeal cancer and the same number of persons without malignant disease (control group-CG). Risk analyses were done using unconditional logistic regression, which provides results in the form of adjusted odds ratio. The odds ratios and their 95% confidence intervals (CI) were computed. Results: Among patients were 79% of current smokers (CS), 18.3% of former smokers (FS) and only 2.7% of never smokers (NS), compared with 40.5% of CS, 28.7% of FS and 30.8% of NS among controls. More than a half of the CS has been smoking 21-40 cigarettes per day (c/day) (54.8%), while in CG members this percent was 29.3%. Group of so called “heavy” smokers (> 40c/day), includes 13.7% of patients, and only 4% from CG. Majority of CS with LarC had smoking length, ranging from 31-45 years (56.2%). CS had 16.03 (95% CI, 6.25-41.12), times significantly higher risk to become ill from LarC, compared with NS. CS who were smoking < 20 c/day had 10.49 (95% CI, 3.87-28.45), while those who were smoking > 20 c/day, had 45.6 (95% CI, 16.55-125.67), times significantly higher risk to become ill, compared with NS. Univariate analysis in CS showed significantly higher risk for the persons to become ill, who were smoking > 40 years, compared with those who were smoking < 40 years (OR=3.73; 95% CI 2.03-6.84). The risk of occurring LarC has been four times (95% CI, 2.35-7.88), significantly higher in the CS who are smoking > 20 years, > 20 c/day, compared with those, who in the same time period, smoke < 20 c/day. Conclusion: Cigarette smoking is by far the most important risk factor for laryngeal cancer. Concerted control of smoking appears to be an urgent priority in LarC prevention, including efforts to prevent adolescents from starting to smoke. </jats:p>
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    Endothelial Cyst of the Left Adrenal Gland in Female Patient Presented as a Cystic Tumor of the Pancreas: A Case Report
    (International Institute for Science, Technology and Education, 2021-01)
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    Zuferi, Agron
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    Limani, Nimetula
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    Right-sided colonic diverticulitis in the young population
    (Shiraz University of Medical Sciences, 2023-12)
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    Although it is a condition of the elderly, diverticular disease (especially in the right colon) is seen in patients under the age of 50. In the past two decades, there have been an increasing number of reports on right-sided colon diverticulitis in the young population. Etiological and epidemiological studies give us partial answers on the occurrence of this condition. The sidedness and the fact that it occurs in younger populations makes this condition actual in terms of early and proper diagnosis thus avoiding unnecessary surgical explorative laparoscopies, laparotomies, appendectomies, etc. Most of the cases with acute right-sided colonic diverticulitis are mild, thus requiring a conservative treatment. However, complicated right-sided colonic diverticulitis is treated with some kind of intervention (percutaneous drainage or surgery). No treatment guidelines are present yet and the approach should be individualized and tailored according to the patient's condition and the severity of the diverticulitis. In case of a clinical deterioration, surgery should be considered regardless open or minimally invasive.
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    SOCIO-DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF LUNG CANCER PATIENTS IN NORTH MACEDONIA
    (Macedonian Association of Anatomists, 2024-04)
    Dimitrievska, Ljubica
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    Stefanoska, Julijana
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    Nehteparova, Meliha
    Lung cancer disease is one of the most common causes of mortality in the world, coming right after cardiovascular diseases. It is a big and is a special problem in the highly developed countries, especially in the USA, but also in developing countries. The reason for the research is the fact that the number of newly diagnosed and death cases from lung cancer is constantly growing, especially in the last few years. The aim of the study is to determine the influence of socio-demographic factors in the occurrence of lung cancer(gender, age, national and ethnic origin, place of residence) and smoking as the main risk factor associated with this neoplasm. The research is a descriptive study in which 82 patients with pathohistological confirmed lung cancer participated. It was implemented at the Institute for Oncology and Radiotherapy at the clinical center in Skopje for a period of 3 months. A total of 82 patients were registered from Institute for Oncology and Radiotherapy in Skopje, North Macedonia who were diagnosed with primary lung cancer. Of all, 64.7% of them were males and 35.3% were females. Histologically, 51.2% had adenocarcinoma, 25.6 had squamous cell carcinoma, 20.7% had small cell carcinoma and 7.4% had no small cell carcinoma. It was observed that the proportion of females diagnosed with primary lung cancer is increasing. Patients get diagnosed at a later stage of the disease, which calls for screening and early detection of lung cancer.
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    RISING TREND OF USING LAPAROSCOPY IN THE TREATMENT OF COMPLICATED APPENDICITIS IN OUR INSTITUTION DURING JANUARY 2017-MAY 2019
    (Македонско лекарско друштво = Macedonian Medical Association, 2019)
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    Gjorgji Stavridis
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    Igor Fildishevski
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    Abstract Introduction. Laparoscopic appendectomy was performed for the first time in the University Clinic for Surgery “St. Naum Ohridski” back in 2003 by the pediatric surgeons. At the moment it is still unrecognized by many senior surgeons as a reliable and safe alternative procedure for acute appendicitis. The end-point of this study is to present the rising trend of using laparoscopy in the treatment of complicated appendicitis. Methods. In the period between January 2017 and May 2019 a total number of 403 patients were operated on due to a preoperative diagnosis of acute appendicitis (270 with open and 133 with laparoscopic appendectomy) and were retrospectively analyzed. Results. Simple appendicitis was diagnosed intraoperatively in 248 patients and complicated appendicitis was diagnosed in 141 patients. The rising trend for overall use of laparoscopy for acute appendicitis was seen during the study period (20.9%, 32.2% and 63.3% in 2017, 2018 and 2019, respectively). In terms of complicated appendicitis, a drastic positive trend followed in favor of laparoscopy (8.9%, 24.6% and 36.7% in 2017, 2018 and 2019, respectively). The negative appendectomy rate with other intraoperative finding was 3.46% (14 cases). The conversion rate was 2.25%. Conclusion. We can finally conclude that the laparoscopic appendectomy is recognized as an effective and safe alternative in the treatment of complicated appendicitis in our institution.