Manusheva, Nensi

Preferred name

Manusheva, Nensi

Official Name

Manusheva, Nensi

Translated Name

Манушева, Ненси

Alternative Name

Manuseva, Nensi

Manusheva, N

Manuseva, N

Nensi Manusheva

Ненси Манушева

Nensi Manuseva

Main Affiliation

nensi.manuseva@medf.ukim.edu.mk

Now showing 1 - 10 of 24

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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume
(Wiley, 2023-03)
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Aleksovski, Boris
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Mihajlovska Rendevska, Ana
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We aimed to analyze the inflammatory and oxidative stress (OS) markers after intracerebral hemorrhage (ICH) and their temporal changes, interaction effects, and prognostic values as biomarkers for the prediction of the edema volume. Our prospective, longitudinal study included a cohort group of 73 conservatively treated patients with ICH, without hematoma expansion or intraventricular bleeding, which were initialized with the same treatment and provided with the same in-hospital care during the disease course. Study procedures included multilevel comprehensive analyses of clinical and neuroimaging data, aligned with the exploration of 19 inflammatory and five OS markers. White blood cells (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophilia, and lymphopenia peaked 3 days post-ICH, and they showed much stronger correlations with clinical and neuroimaging variables, when compared to the admission values. An intricate interplay among inflammatory (WBC, CRP, neutrophils, neutrophil-to-lymphocyte ratio [NLR], interleukin (IL)-6, and IL-10) and OS mechanisms (catalase activity and advanced oxidation protein products [AOPP]) was detected operating 3-days post-ICH, being assessed as relevant for prediction of the edema. The overall results suggested complex pathology of formation of post-ICH edema, via: (A) Not additive, but statistically significant synergistic interactions between CRP-ESR, neutrophils-CRP, and neutrophils-IL-6 as drivers for the edema formation; (B) Significant antagonistic effect of high protein oxidation on the CRP-edema dependence, suggesting a mechanism of potential OS-CRP negative feedback loop and redox inactivation of CRP. The final multiple regression model separated the third-day variables NLR, CRP × AOPP, and WBC, as significant prognostic biomarkers for the prediction of the edema volume, with NLR being associated with the highest effect size. Our developed mathematical equation with 3D modeling for prediction and quantification of the edema volume might be beneficial for taking timely adequate strategies for prevention of delayed neurological deteriorations.
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RELATION BETWEEN FAMILY HISTORY, AGE OF ONSET, RELAPSES OF THE DISORDER AND SERUM CORTISOL, DEHYDROEPIANDROSTERONE SULFAT AND THEIR RATIO IN SCHIZOPHRENIA
(University Ss. Cyril and Methodius in Skopje, 2022)
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Main effects of sleep disorders related to shift work-opportunities for preventive programs
(Springer Science and Business Media LLC, 2011-12)
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Novotni, A
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Miceva-Velickovska, Elizabet
The sleep-related problems of shift workers usually occur as transient phenomena related to the timing of work. Sleep disorders, related to sleep deprivation, have a major impact on the quality of life and health status of healthcare workers. Reduced quantity and quality of sleep negatively affects the activities of shift workers, particularly in terms of their social functioning, quality of life and health. However, it seems that health authorities and the medical staff are negligent when it comes to the negative effects on health caused by work in night shifts. Recently published studies in this field suggest that appropriate public health preventive programs dealing with sleep disorders successfully contribute towards the quality of life of workers.
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Depression and insomnia among students during COVID-19 pandemic - cross sectional study
(National Library of Serbia, 2023)
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Aleksovski, Boris
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Bukovetz, Jansun
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<jats:p>Introduction/Objective In the first year of COVID-19 pandemic, global prevalence of anxiety and depression increased by a massive 25%, according to the World Health Organization. Objective of the study was to determine the level of depression and insomnia among students in North Macedonia during COVID-19 pandemic. Methods Cross-sectional study was performed among students at the Ss. Cyril and Methodius University in Skopje during May-July of 2021. The anonymous online survey contained questions for sex, age, their opinion, and attitude to COVID-19 infection, if they had any infection/isolation and about physical activity during the pandemic. We used scales for assessment of insomnia (Insomnia Severity Index - ISI) and depression (Patient Health Questionnaire 9 - PHQ-9). Results The study was completed by 355 participants, 28.4% of them had clinically important insomnia scores and almost 47.5% of the participants presented clinically important depression scores. Female and younger participants had higher scores for both scales. A highly statistically significant, positive correlation was detected between ISI and PHQ-9 scores (? = 0.646, p = 4.05?10-43), suggesting that during the examined cross-sectional period of COVID-19 pandemics, depression and insomnia were mutually connected. Conclusions COVID-19 pandemic caused a serious impact on mental health of the population, especially on young people, girls, students, and those who live alone. Therefore, we should be prepared for support and treatment of these vulnerable groups, not only as health care services, but also as educational institutions to give support to students in terms of consultation and motivation.</jats:p>
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Mental health in Central and Eastern Europe: a comprehensive analysis
(Elsevier BV, 2025-10)
Winkler, Petr
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Guerrero, Zoe
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Kågström, Anna
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Petrášová, Michaela
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Pashoja, Arlinda Cerga
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Depression and insomnia among students during COVID-19 pandemic - cross sectional study
(National Library of Serbia, 2023)
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Aleksovski, Boris
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Bukovetz, Jansun
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<jats:p>Introduction/Objective. In the first year of the COVID-19 pandemic, global prevalence of anxiety and depression increased by a massive 25%, according to the World Health Organization. The objective of the study was to determine the level of depression and insomnia among students in North Macedonia during the COVID-19 pandemic. Methods. A cross-sectional study was performed among students of the Ss. Cyril and Methodius University in Skopje during May?July of 2021. The anonymous online survey contained questions regarding their sex, age, their opinion and attitude towards the COVID-19 infection, if they had any infection/isolation, and about physical activity during the pandemic. We used scales for assessment of insomnia (Insomnia Severity Index ? ISI) and depression (Patient Health Questionnaire 9 ? PHQ-9). Results. The study was completed by 355 participants, 28.4% of them had clinically important insomnia scores and almost 47.5% of the participants presented clinically important depression scores. Female and younger participants had higher scores for both scales. A highly statistically significant, positive correlation was detected between ISI and PHQ-9 scores (? = 0.646, p = 4.05 ? 10-43), suggesting that during the examined cross-sectional period of the COVID-19 pandemic, depression and insomnia were mutually connected. Conclusion. The COVID-19 pandemic caused a serious impact on mental health of the population, especially on young people, girls, students, and those who live alone. Therefore, we should be prepared for support and treatment of these vulnerable groups, not only as health care services, but also as educational institutions, to provide support to students in terms of consultation and motivation.</jats:p>
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HYPONATREMIA IN OLANZAPINE TREATED PATIENT
(Department of Anaesthesia and Reanimation, Faculty of Medicine, “Ss. Cyril and Methodius” University Skopje, R.N.Macedonia, 2021-06)
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Chabukovska E
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Hyponatremia is sodium level imbalance, defined as levels below 135 mmol/l. Numerous factors may lie in its etiology and pathogenesis including psychotropic drug use, and in such cases hyponatremia is an adverse event. The syndrome of inappropriate secretion of antidiuretic hormone secretion (SIADH) has been reported with the use of antidepressants, antipsychotics and mood stabilizers. The exact pathophysiological mechanisms for this syndrome are still in the process of investigation. The findings so far indicate: increased secretion of ADH from hypothalamus as a result of dopamine-D2 receptor inhibition (suppression of the inhibitory effect of dopamine on ADH secretion), as well as the effect of 5-HT2 and 5-HT1C serotonin receptors which also leads to an increase in ADH levels and potentiation of its effect at the renal level. Having seen similar symptoms in SIADH and in psychiatric entities, it can cause hyponatremia to remain unrecognized in clinical practice, especially if mild and if it develops slowly. However, in some cases it may progress to severe hyponatremia which becomes an urgent condition. On the other hand, if recognized and treated in time, there is a satisfactory outcome. We report a case-report of 64-year-old woman who has been treated for a schizophrenia disorder for thirty years with good remission of symptoms by regular use of antipsychotics (orally and in depot form). The current deterioration occurred in the last five months, due to non-compliance to the treatment. During treatment hyponatremia was induced by the second generation of antipsychotic drug. In conclusion we recommend for clinicians not only to be cautious when prescribing psychotropic drugs, and to assess sodium laboratory values and clinical symptoms for all patients after initiation of antipsychotic drug as a routine clinical practice, but also to take into account differential diagnoses for presented symptoms
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Inflammatory and oxidative stress markers in intracerebral hemorrhage: Relevance as prognostic markers for quantification of the edema volume
(2023-03)
Rendevski, Vladimir
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Aleksovski, Boris
;
Mihajlovska Rendevska, Ana
;
Hadzi-Petrushev, Nikola
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We aimed to analyze the inflammatory and oxidative stress (OS) markers after intracerebral hemorrhage (ICH) and their temporal changes, interaction effects, and prognostic values as biomarkers for the prediction of the edema volume. Our prospective, longitudinal study included a cohort group of 73 conservatively treated patients with ICH, without hematoma expansion or intraventricular bleeding, which were initialized with the same treatment and provided with the same in-hospital care during the disease course. Study procedures included multilevel comprehensive analyses of clinical and neuroimaging data, aligned with the exploration of 19 inflammatory and five OS markers. White blood cells (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophilia, and lymphopenia peaked 3 days post-ICH, and they showed much stronger correlations with clinical and neuroimaging variables, when compared to the admission values. An intricate interplay among inflammatory (WBC, CRP, neutrophils, neutrophil-to-lymphocyte ratio [NLR], interleukin (IL)-6, and IL-10) and OS mechanisms (catalase activity and advanced oxidation protein products [AOPP]) was detected operating 3-days post-ICH, being assessed as relevant for prediction of the edema. The overall results suggested complex pathology of formation of post-ICH edema, via: (A) Not additive, but statistically significant synergistic interactions between CRP-ESR, neutrophils-CRP, and neutrophils-IL-6 as drivers for the edema formation; (B) Significant antagonistic effect of high protein oxidation on the CRP-edema dependence, suggesting a mechanism of potential OS-CRP negative feedback loop and redox inactivation of CRP. The final multiple regression model separated the third-day variables NLR, CRP × AOPP, and WBC, as significant prognostic biomarkers for the prediction of the edema volume, with NLR being associated with the highest effect size. Our developed mathematical equation with 3D modeling for prediction and quantification of the edema volume might be beneficial for taking timely adequate strategies for prevention of delayed neurological deteriorations.
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Evaluation of peripheral serotonin content and α2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements
(Informa UK Limited, 2018-09)
Aleksovski, Boris
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Vujović, Viktorija
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We aimed to evaluate the role and the relations between peripheral platelet serotonin content, blood plasma serotonin concentration and the function of platelet α2-adrenergic receptors (α2-AR) as potential state or trait biomarkers for recurrent depressive disorder (RDD).
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Correlation Between the Different Types of Antipsychotics and Serum Cortisol, Dehidroepiandrosterone Sulfat and their Ratio in Schizophrenia
(Walter de Gruyter GmbH, 2022-03-01)
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<jats:title>Abstract</jats:title> <jats:p> <jats:bold>Background</jats:bold>: Evidence for disturbances in HPA activation and abnormal HPA regulatory mechanisms in schizophrenia is accumulating.</jats:p> <jats:p> <jats:bold>Aim</jats:bold>: To compare serum levels of cortisol, DHEA-S and their ratio between patients with schizophrenia and healthy controls and among patients before and after treatment with different types of antipsychotics.</jats:p> <jats:p> <jats:bold>Material and methods</jats:bold>: In this clinical prospective study, 60 patients with schizophrenia and 40 healthy age and sex matched control subjects were included. All patients experienced an acute exacerbation of the illness (PANSS: P1 and P3 ≥ 4). Clinical evaluation of patients was performed using the Positive and Negative Symptom Scale. A questionnaire for socio-demographic and clinical data collection was used. Serum levels of cortisol, DHEA-S and their ratio were measured at baseline in all participants and after 3 and 6 weeks, respectively, of the antipsychotic treatment with different types of antipsychotics in patients with schizophrenia.</jats:p> <jats:p> <jats:bold>Results</jats:bold>: Patients with schizophrenia had significantly higher serum cortisol and DHEA-S levels in comparison to the control group. There was no significant difference in serum levels of cortisol, DHEA-S and their ratio between patients treated with different types of antipsychotics (typical/atypical). Serum levels of the analyzed hormones significantly reduce during the 6-week period of examination in both subgroups treated with different types of antipsychotics.</jats:p> <jats:p> <jats:bold>Conclusion</jats:bold>: Elevated serum cortisol and DHEA-S in schizophrenic patients might be associated with their role in the pathophysiology of the disorder. There is no significant difference in serum levels of cortisol, DHEA-S and their ratio among the patients treated with different types of antipsychotics.</jats:p>

Manusheva, Nensi

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