Dimitrovski, Kocho

Preferred name
Dimitrovski, Kocho
Official Name
Dimitrovski, Kocho
Main Affiliation
Email
kocho.dimitrovski@medf.ukim.edu.mk

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    Distribution of the most Common Genetic Variants Associated with a Variable Drug Response in the Population of the Republic of Macedonia
    (Walter de Gruyter GmbH, 2014-12)
    Kapedanovska Nestorovska, A
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    Naumovska, Z
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    Hiljadnikova Bajro, M
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    Sterjev, Z
    Genetic variation in the regulation, expression and activity of genes coding for Phase I, Phase II drug metabolizing enzymes (DMEs) and drug targets, can be defining factors for the variability in both the effectiveness and occurrence of drug therapy side effects. Information regarding the geographic structure and multi-ethnic distribution of clinically relevant genetic variations is becoming increasingly useful for improving drug therapy and explaining inter-individual and inter-ethnic differences in drug response. This study summarizes our current knowledge about the frequency distribution of the most common allelic variants in three broad gene categories: the Phase I oxidation-cytochrome P450 (CYP450) family (CYP2C9, CYP2C19, CYP3A5, CYP2D6); the Phase II conjugation (GSTT1, SULT1A1; UGT1A1) and drug target (TYMS-TSER, MTHFR and VKORC1) in the population of the Republic of Macedonia and compares the information obtained with data published for other indigenous European populations. Our findings define the population of the Republic of Macedonia as an ethnic group with a highly polymorphic genetic profile. These results add to the evidence regarding the distribution of clinically important variant alleles in DME and drug target genes in populations of European ancestry.
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    The Presence of Some Humoral Immunologic Indicators and Clinical Manifestations in Cryoglobulin Positive Heroin Addicts without Evidence of Hepatitis Virus Infection
    (2015-05)
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    Andon Chibishev
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    Cvetanka Bozinovska
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    SUMMARY Introduction Cryoglobulins are single or mixed immunoglobulins that are subject to reversible precipi￾tation at low temperatures. Objective The aims of this paper were: 1. Comparison of cryoglobulin positive (CP), cryoglobulin nega￾tive (CN) heroin addicts and the control group (CG) in terms of serum immunoglobulins IgG, IgA and IgM and complement components C3 and C4; 2. Comparison of CP and CN heroin addicts in terms of rheumatoid factor (RF) and circulating immune complexes (CIC); 3. Assessment of clinical manifestations in CP heroin addicts. Methods This is a comparative study of cases (outpatients) treated at the University Clinic of Toxicology in Skopje over 3.5 years, from January 2009 to June 2012. In this study 140 heroin addicts without HbsAg were examined, seronegative for HCV and HIV infections. They were divided into 2 groups: 70 CP and 70 CN heroin addicts. A previously designed self-administered questionnaire was used as a data source on participants. All heroin addicts underwent the following analyses: urea and creatinine in serum; creati￾nine in urine; proteinuria; 24-hour proteinuria; IgM, IgG, IgA, C3, C4 ; RF; CIC; creatinine clearance; ECG; toxicological analyses for opioids in a urine sample; cryoglobulins. In addition to these 2 groups, IgG, IgA, IgM, C3 and C4 were also examined in 70 healthy subjects (CG). Results The study showed that there was no statistically significant difference between CP, CN heroin ad￾dicts and CG regarding the concentration of IgA, IgG, IgM, C3 and C4, and between CP and CN regarding the concentration of CIC. There was significant difference between CP and CN regarding the concentra￾tion of RF. The following conditions were significantly more frequently manifested in CP than in CN heroin addicts: arthralgia, Raynaud’s phenomenon, respiratory difficulties, neurological disorders, manifested skin changes, hematuria, 24-hour proteinuria levels, and decreased renal clearance. Conclusion There were no differences in concentrations of IgG, IgA, IgM, C3, C4 and CIC, while there was a difference in concentration of RF between CP and CN heroin addicts. Clinical manifestations (arthralgias, Raynaud’s phenomenon, respiratory, neurologic, renal disorders and skin changes) were more common in CP heroin addicts.
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    Urinary Proteomics in Kidney Transplantation
    (Macedonian Academy of Sciences and Arts/Walter de Gruyter GmbH, 2021-12-01)
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    Dohcev, Sasho
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    Although kidney transplantation is the best treatment option for end stage kidney disease, it is still associated with long-term graft failure. One of the greater challenges for transplant professionals is the ability to identify grafts with a high risk of failure before initial decline of eGFR with irreversible graft changes. Transplantation medicine is facing an emerging need for novel disease end point-specific biomarkers, with practical application in preventive screening, early diagnostic, and improved prognostic and therapeutic utility. The aim of our review was to evaluate the clinical application of urinary proteomics in kidney transplant recipients at risk for any type of future graft failure.
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    Acute fulminant hepatatis in kidney transplant recipient after repeated sevoflurane anesthesia--a case report and literature review
    (Bentham Science Publishers Ltd., 2013-04)
    Masin-Spasovska, Jelka
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    Dohchev, Saso
    A liver dysfunction induced by halogenated volatile anaesthetics is considered as a significant diagnostic problem. The aim of our report was to describe the first case of lethal hepatic failure in a female patient undergoing kidney transplantation (KTx) from a living donor after repeated sevoflurane anaesthesia.
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    Effects of data transformation on multivariate analyses in intracerebral hemorrhage
    (Macedonian Pharmaceutical Association, 2016)
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    Aleksovski, Boris
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    Kolevska, Milena
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    Stojanov, Dragan
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    <jats:p>Multivariate statistical approaches have been increasingly applied in hemorrhagic stroke data analysis. Nevertheless, several aspects regarding their relevance and validity in respect of the application of data transformations have not been studied in details. This paper examines the effects of different data transformations in the standard statistical methods of the multivariate analysis of the intracerebral hemorrhage (ICH) parameters in small group samples. Two different methods for data transformations (log transformation (log(Xi )), square root transformation (√Xi ))have been carried out. The initial volume of the ICH have been studied using several test for skewness, kurtosis, histogram distribution method and different quartile-quartile (Q-Q) and probability-probability (P-P) plots as criteria for normal distribution. Multivariate analyses for the prediction of the perifocal edema was performed using raw and transformed data. Our results indicate that the data transformation operations should be performed very carefully because different analytical outputs lead to different scientific conclusions.</jats:p>
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    Covid infection as devastating post-transplant complication
    (Macedonian Society of Nephrology, Dialysis, Transplantation and Artificial Organs, 2020)
    Dohchev, Sasho
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    Trifunovski, Aleksandar
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    Trajkovski, Dimitar
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    Janchulev, Josif
    In march 2020 Covid 19 was declared as a pandemic by World Health Organisation. The marked risk group were older patients and patients with comorbidity such as hypertension, DM, obstructive pulmonary disease and chronic kidney disease. Patients on dialysis and kidney transplant recipients are among highest risk groups to be infected with Corona virus. Since the very beginning, Corona virus pandemic have great impact on the transplant program worldwide. There are recommendations for kidney transplant profe- ssionals that suggest the prioritization of patients for kidney transplantation. We present an expanded criteria donor, and recipient with multiple vascular access problems as an indication for kidney transplantation. In the early posttransplant period vascular problems with implication on the graft function were diagnosed and surgically treated, and cholecystecto- my was performed due to an uncalculous cholecystitis. Unexpected Corona virus infection early post transplan- tation occurred as a devastating complication for our kidney transplant recipient.