Makreski, Petre

Preferred name

Makreski, Petre

Official Name

Makreski, Petre

Main Affiliation

Web Site

https://ih.pmf.ukim.edu.mk/teachers/view/127

petremak@pmf.ukim.mk

petremak@gmail.com

Scopus Author ID

8924201100

Researcher ID

AAK-6396-2021

Now showing 1 - 10 of 60

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Solid-State Phase Transformation of Monohydrate and Anhydrous Form II of Sitagliptin Phosphate into a Novel Anhydrous Form IV – Solvent-Driven, Temperature-Induced and Stress Testings
(Elsevier BV, 2024-02)
Chachorovska, Marina
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Lefton, Jonathan B.
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Petrushevski, Gjorgji
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Geskovski, Nikola
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Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour
(Springer Science and Business Media LLC, 2022-06-01)
Koummich, Sarra Aicha
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Zoukh, Ikram Mustapha
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Gorachinov, Filip
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Geskovski, Nikola
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TY - JOUR AU - Koummich, Sarra Aicha AU - Zoukh, Ikram Mustapha AU - Gorachinov, Filip AU - Geskovski, Nikola AU - Makreski, Petre AU - Dodov, Marija Glavas AU - Goracinova, Katerina PY - 2022 DA - 2022/06/01 TI - Design of ophthalmic micelles loaded with diclofenac sodium: effect of chitosan and temperature on the block-copolymer micellization behaviour JO - Drug Delivery and Translational Research SP - 1488 EP - 1507 VL - 12 IS - 6 AB - Diclofenac sodium 0.1% is a commonly used NSAID with well-documented clinical efficacy in reducing postoperative inflammation; however, its corneal tolerability and ophthalmic tissue bioavailability require further improvement. Advanced micellar delivery systems composed of block-copolymers and chitosan showing fine balance between the mucoadhesion and mucus permeation, capable to slip through the mucus barrier and adhere to the epithelial ocular surface, may be used to tackle both challenges. The aggregation behaviour of the block-copolymers in the presence of different additives will dramatically influence the quality attributes like particle size, particle size distribution, drug-polymer interaction, zeta potential, drug incorporation, important for the delicate balance among mucoadhesion and permeation, as well as safety and efficacy of the ophthalmic micelles. Therefore, quality by design approach and D-optimal experimental design model were used to create a pool of useful data for the influence of chitosan and the formulation factors on the block copolymer’s aggregation behaviour during the development and optimization of Diclofenac loaded Chitosan/Lutrol F127 or F68 micelles. Particle size, polydispersity index, dissolution rate, FTIR and DSC studies, NMR spectroscopy, cytotoxicity, mucoadhesivity, mucus permeation studies, and bioadhesivity were assessed as critical quality attributes. FTIR and DSC studies pointed to the chaotropic effect of chitosan during the micelle aggregation. Mainly, Pluronic F68 micellization behaviour was more dramatically affected by the presence of chitosan, and self-aggregation into larger micelles with high polydispersity index was favoured at higher chitosan concentration. The optimized formulation with highest potential for ophthalmic delivery of diclofenac sodium, good cytotoxicity profile, delicate balance of the mucoadhesivity, and mucus permeation was in the design space of Chitosan/Lutrol F127 micelles. SN - 2190-3948 UR - https://doi.org/10.1007/s13346-021-01030-4 DO - 10.1007/s13346-021-01030-4 ID - Koummich2022 ER -
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PVDF/BaTiO3 composite foams with high content of β phase by thermally induced phase separation (TIPS)
(Springer Science and Business Media LLC, 2022-06-15)
Bužarovska, Aleksandra
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Kubin, Mateja
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Zanoni, Michele
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Gasperini, Leonardo
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Design and evaluation of nanostructured lipid carriers loaded with Salvia officinalis extract for Alzheimer's disease treatment
(Wiley, 2022)
Markova, Elena
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Taneska, Lea
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Kostovska, Monika
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Shalabalija, Dushko
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Mihailova, Ljubica
Considering the potential of Salvia officinalis in prevention and treatment of Alzheimer's disease (AD), as well as the ability of nanostructured lipid carriers (NLC) to successfully deliver drug molecules across blood-brain barrier (BBB), the objective of this study was design, development, optimization and characterization of freeze-dried salvia officinalis extract (FSE) loaded NLC intended for intranasal administration. NLC were prepared by solvent evaporation method and the optimization was carried out using central composite design (CCD) of experiments. Further, the optimized formulation (NLCo) was coated either with chitosan (NLCc) or poloxamer (NLCp). Surface characterization of the particles demonstrated a spherical shape with smooth exterior. Particle size of optimal formulations after 0.45 μm pore size filtration ranged from 127 ± 0.68 nm to 140 ± 0.74 nm. The zeta potential was -25.6 ± 0.404 mV; 22.4 ± 1.106 mV and - 6.74 ± 0.609 mV for NLCo, NLCc, and NLCp, respectively. Differential scanning calorimetry (DSC) confirmed the formation of NLC whereas Fourier-transform infrared spectroscopy confirmed the FSE encapsulation into particles. All formulations showcased relatively high drug loading (>86.74 mcg FSE/mg solid lipid) and were characterized by prolonged and controlled release that followed Peppas-Sahlin in vitro release kinetic model. Protein adsorption studies revealed the lowest adsorption of the proteins onto NLCp (43.53 ± 0.07%) and highest protein adsorption onto NLCc (55.97 ± 0.75%) surface. The modified ORAC assay demonstrated higher antioxidative activity for NLCo (95.31 ± 1.86%) and NLCc (97.76 ± 4.00%) as compared to FSE (90.30 ± 1.53%). Results obtained from cell cultures tests pointed to the potential of prepared NLCs for FSE brain targeting and controlled release.
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Solid-state compatibility screening of excipients suitable for development of indapamide sustained release solid-dosage formulation
(Informa UK Limited, 2013)
Antovska, Packa
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Petruševski, Gjorgji
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Differential scanning calorimetry and Fourier transform infrared spectroscopy were applied as screening analytical methods to assess the solid-state compatibility of indapamide (4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoyl-benzamide) with several polymers aimed for development of 24 h sustained release solid-dosage formulation. After the initial research phase which was directed towards selection of suitable polymer matrices, based on their solid-state compatibility with the studied pharmaceutical active ingredient, the second phase of evaluation was intended for compatibility selection of other excipients required to complete a sustained release formulation. The preformulation studies have shown that polyvinylpyrrolydone/polyvinyl acetate might be considered incompatible with indapamide, and the implementation of this polymer career should be avoided in the case of the entitled development. The experimental data additionally have revealed that sorbitol is incompatible with indapamide. The obtained results afforded deeper insight in to the solid-state stability of the studied binary systems and pointed out directions for further development of indapamide sustained release solid-dosage formulation.
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Minerals from Macedonia. XXVII: Theoretical and experimental study of the vibrational spectra of endemic nežilovite
(Elsevier BV, 2011-05)
Stamatovska, Nikolina
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Pejov, Ljupčo
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Jovanovski, Gligor
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Pholcodine monohydrate: Crystal structure and polymorphism
(Elsevier BV, 2013-07)
Petruševski, Gjorgji
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Zbačnik, Marija
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Kajdžanoska, Marina
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Ugarkovic, Sonja
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Trimčeski, Vase
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Near-infrared spectroscopy study for determination of adsorbed acetochlor in the organic and inorganic bentonites
(Elsevier BV, 2012-12)
Tomić, Zorica P
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Ašanin, Darko
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Đurović, Rada
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Đorđević, Aleksandar
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NIR spectroscopy is used to determine acetochlor herbicide adsorption on Na-montmorillonite (NaP) and organically modified montmorillonite (NaOM). Both montmorillonites NIR spectra shows bands at 7061 and 6791 cm(-1). Organo-montmorillonite is characterised by two emphasized bands at 5871 and 5667 cm(-1) that are attributed to the fundamental overtones of the mid-IR bands at 2916 and 2850 cm(-1). Bands at 6017 and 6013 cm(-1) are attributed to acetochlor adsorbed to organo-montmorillonite and Na-montmorillonite, which is confirmed by X-ray powder diffraction (XRPD). Greater quantity of acetochlor is adsorbed to organo-clays compared to non-modified montmorillonite. Acetochlor poses high risk to environmental contamination. Organo-clays are the most useful for removing acetochlor from water and soil.
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Laser-induced transformation of stibnite (Sb2S3) and other structurally related salts
(Elsevier BV, 2013-09)
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Petruševski, Gjorgji
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Ugarković, Sonja
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Jovanovski, Gligor
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Intriguing minerals: quartz and its polymorphic modifications
(Springer Science and Business Media LLC, 2022-05-10)
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Šijakova-Ivanova, Tena
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Boev, Ivan
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Boev, Blažo
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Makreski, Petre

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