Nikolovski, Andrej

Preferred name

Nikolovski, Andrej

Official Name

Nikolovski, Andrej

Main Affiliation

andrej.nikolovski@medf.ukim.mk

andrejnikolovski05@gmail.com

Now showing 1 - 10 of 74

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Assessment of the Level of Middle Colic Artery Ligation Influence on Survival in Right-Sided Colon Cancer
(Walter de Gruyter GmbH, 2025-06-01)
Ulusoy, Cemal
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Duman, Mehmet Güray
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Aim: This study aims to investigate whether the addition of ligation of the Middle Colic Artery in its origin to Complete Mesocolic Excision (CME) with Central Vascular Ligation (CVL) affects overall survival and lymph node retrieval. Method: Patients with right-sided colon cancer who underwent curative right or extended right hemicolectomy with CME and CVL were included. In cases with tumors located in the distal part of the ascending colon and the hepatic flexure, the middle colic artery was ligated in its origin. For the cecal and proximal localization of the tumor, the point of ligation was decided on the surgeons' decision. Results: A total number of 169 patients were operated. In 78 patients the tumor was localized in the caecum, in 70 patients in the ascending colon, and 21 in the hepatic flexure. In 59 patients, the middle colic artery was ligated in its origin. Different artery ligation sites according to tumor localization subgroup presented with statistical significance (P = 0.004). The mean number of harvested lymph nodes between the groups was presented with a difference (33.4 vs. 28.5; P = 0.037). Survival rates for cecal, ascending, and hepatic flexure cancer were as follows: 61.5%, 67.1%, and 85.7%, respectively (P = 0.22). The survival rate for all patients was 66.9% (69.5% for patients with middle colic artery ligation and 65.5% for the right branch of middle colic artery ligation, P = 0.42). Conclusion: Ligation of the middle colic artery in its origin did not improve overall survival. However, it resulted in a significantly higher number of harvested lymph nodes.
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Radiation-induced rectal leiomyosarcoma in a cervical cancer survivor: a case report
(Oxford University Press (OUP), 2025-08)
Sulejmani, Haris
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Vasilevski, Filip
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Rectal leiomyosarcoma (LMS) is an exceptionally rare malignancy, representing ˂0.5% of all rectal cancers. Even more uncommon are the cases of radiation-induced LMS arising as an independent malignancy following pelvic radiotherapy. We report a case of a 56-year-old female patient with a history of high-grade large cell neuroendocrine cervical carcinoma treated 12 years earlier with radical hysterectomy and adjuvant chemoradiotherapy. The patient presented with rectal discomfort and altered bowel habits. A colonoscopy revealed a near-obstructing polypoid rectal mass, and a biopsy confirmed LMS. Surgical treatment via abdominoperineal resection with total mesorectal excision was performed. Adjuvant chemotherapy was conducted by an oncologist. Given the long latency period and absence of metastases, the tumor was stated as a radiation-induced primary malignancy. This case emphasizes the importance of awareness in cancer survivors previously treated with pelvic radiotherapy and highlights the critical role of surgery in the management of rectal LMS.
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Uncommon causes of acute appendicitis: Retrospective analysis of 6785 histopathological findings in a tertiary center
(Kare Publishing, 2022-12)
Harman Kamali, Gülçin
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Ulusoy, Cemal
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Eğin, Seracettin
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Kamalı, Sedat
This study aims to determine the uncommon causes of acute appendicitis in analyzed post appendectomy specimens.
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Incidentally diagnosed large asymptomatic Morgagni hernia in adult male patient
(SMC Media, 2023-08-31)
Misimi, Shqipe
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Shurlani, Arben
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<jats:p>Background: Congenital diaphragmatic hernias are rare congenital defects resulting in abdominal organ protrusion into the thoracic cavity; they mainly present with pulmonary or gastrointestinal symptoms. Although congenital and discovered in utero or in early childhood, they can be asymptomatic for a long time and even remain asymptomatic despite the growing hernia sac dimensions and the hernia sac contents. Case description: We present a case of a 58-year-old patient with incidentally diagnosed Morgagni hernia during the COVID-19 pandemic following a computerised tomography (CT) scan of the chest. He presented without any symptoms related to the existence of the hernia. Another CT scan was performed 20 months after the initial diagnosis to evaluate the progression of the hernia. The patient refused the offered surgery due to the absence of symptoms. Discussion: A Morgagni hernia is usually discovered during pregnancy or in early childhood, but sometimes can be asymptomatic for years. Main symptoms originate from the respiratory and gastrointestinal system. Conclusion: Due to the refusal of surgery, we were able to follow the CT scan enlargement progression of patients’ hernia over a 20-month period.</jats:p>
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Extranodal Diffuse Large B-Cell Lymphoma of the Small Bowel in Female Patient Causing Intestinal Obstruction: A Case Report
(Vilnius University Press, 2022-12-30)
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Dukovski, Dushko
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Diffuse large B cell lymphoma is the most common extranodal non-Hodgkin lymphoma of the small intestine accounting for more than 50% of cases. Forty percent of these cases initially present with small bowel obstruction. Therefore, the diagnosis is usually established after surgery for bowel obstruction. The treatment is then continued with a certain chemotherapy regimens. We present a case of a 46-years-old female patient with signs of small bowel obstruction due to previously undiagnosed diffuse large B-cell lymphoma. Postoperatively, the patient was treated with 7 cycles of R-CHOP protocol and complete response was achieved in the short follow-up period.</jats:p>
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Multiseptate gallbladder accompanied by an incomplete annular pancreas in a 19-year male patient: A case report
(Elsevier BV, 2025-10)
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Misimi, Shqipe
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Trpeski, Stanko
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Atanasov, Zvonko
Multiseptate gallbladder (MG) is a rare congenital malformation that may occur as an isolated anomaly or in conjunction with other abnormalities of the pancreaticobiliary, urinary, and gastrointestinal systems. The coexistence of MG with an annular pancreas is an exceedingly rare phenomenon. The diagnosis is typically established using abdominal ultrasound; however, further imaging modalities are often required to delineate the detailed anatomy and to identify any associated anomalies within the pancreaticobiliary system. We present a case of a symptomatic MG associated with an incomplete annular pancreas. This case underscores the importance of considering additional congenital anomalies in patients diagnosed with MG, as such associations may influence clinical management and outcomes.
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Large biloma as the initial presentation of gallbladder perforation: a case report and literature review
(Oxford University Press (OUP), 2023-12)
Limani, Nimetula
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Misimi, Shqipe
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Biloma is an encapsulated intra or extra-hepatic collection of bile after biliary tree trauma. Post-procedural and traumatic biliary damage are the most common etiologic causes. Gallbladder perforation due to acute cholecystitis rarely presents with biloma occurrence. We present a case of large extrahepatic biloma formation as a consequence of a perforated gallbladder.
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Giant (complex) inguinal hernia in female patient left untreated for 40 years: a case report
(Oxford University Press (OUP), 2024-11)
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Gjinoska, Klaudia
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Kocevski, Zhivorad
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Stoicovski, Emil
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Mitrev, Zan
A giant inguinal hernia is a rare clinical presentation in patients refusing hernia repair for different reasons during a long period. The appearance is remarkable, and the preoperative preparation and the surgery itself might be challenging. They can present in an emergency (hernia incarceration) or elective setting. Most of the patients are male, but exclusions exist. This is a rare case of a female patient with a giant inguinal hernia left untreated for 40 years.
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Value of MRI in multimodal treatment of locally advanced rectal carcinoma
(Scientific Foundation SPIROSKI, 2020-07-16)
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MRI is a basic tool in patient selection for preoperative neoadjuvant treatment of rectal carcinoma, with assessment of stage reduction. The aim of the paper was to evaluate chemoradiotherapy effects in advanced stage rectal carcinoma by comparison of MRI findings before and after chemoradiotherapy. Material and methods: Prospectively, MRI findings of 15 patients with rectal carcinoma confirmed at colonoscopy, were evaluated. In all patients preoperative neoadjuvant treatment was done and MRI restaging was performed after 6 to 8 weeks. MRI standard protocol was done on 1.5T machine, sagital T2WI, axial T1WI, T2WI and DWI. On MRI was assessed tumor and nodal stage, presence of extra-mural vascular invasion (EMVI), tumor localization within the rectum (low, medium, high rectum, recto-sigmoid junction). Computer tomography was performed in all patients for distant metastases assessment. Results: Out of 15 patients, 12 (66.7%) were male, and 3 (33.3 %) were female, with a mean age of 65 years (range 50 to 80years). Six cases had middle rectum localization, 6 cases in low rectum, and 3 patients had recto-sigmoid localization. At initial MRI, 7 cases (46.6%) had MR signs for T3 stage, and 8 cases (53.3%) had T4 stage. Comparison of MRI results before and after chemoradiotherapy showed stage decreasing in 5(33.3%), from T4 to T3 stage. In 11 patients (73.7%), EMVI after therapy became negative with a statistically significant difference before and after chemoradiotherapy. All patients before therapy had different numbers of metastatic lymph nodes in mesorectum, with number reduction in all cases after therapy and two patients were without metastatic lymph nodes. Conclusion: MRI has a significant value in pre- and post-neoadjuvant therapy assessment of resection margins involved by tumor, positive extramural vascular invasion, and metastatic lymph node around resection margins. This is important for operative planning in order to avoid extensive resection with surgery techniques that preserve the anal sphincter.
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Low-grade malignancy glomus tumor of the abdominal wall: a case report and literature review
(Oxford University Press (OUP), 2023-12)
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Gelevski, Radomir
Glomus tumors are painful neoplasms arising from the glomus body (responsible for body temperature and blood pressure regulation) in the skin. Although mostly present in the interdigital areas, glomus tumors can arise elsewhere. The vast majority of them are benign. Rarely, malignant variants are reported and are associated with the potential for local infiltration and metastatic dissemination. The abdominal wall location of glomus tumors is extremely rare regardless of whether they present as benign or malignant. We present a case of a 58-year-old female patient with a low-grade malignancy infiltrative glomus tumor of the abdominal wall.

Nikolovski, Andrej

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