Petrushevska, Gordana
Preferred name
Petrushevska, Gordana
Official Name
Petrushevska, Gordana
Main Affiliation
Email
gordana.petrusevska@medf.ukim.edu.mk
153 results
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Item type:Publication, AML-327: Plasmacytoid Dendritic Cell Proliferation Associated with Acute Myeloid Leukemia: A Case Report(Elsevier BV, 2021-09); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extranodal Diffuse Large B-Cell Lymphoma of the Small Bowel in Female Patient Causing Intestinal Obstruction: A Case Report(Vilnius University Press, 2022-12-30); ; ; Diffuse large B cell lymphoma is the most common extranodal non-Hodgkin lymphoma of the small intestine accounting for more than 50% of cases. Forty percent of these cases initially present with small bowel obstruction. Therefore, the diagnosis is usually established after surgery for bowel obstruction. The treatment is then continued with a certain chemotherapy regimens. We present a case of a 46-years-old female patient with signs of small bowel obstruction due to previously undiagnosed diffuse large B-cell lymphoma. Postoperatively, the patient was treated with 7 cycles of R-CHOP protocol and complete response was achieved in the short follow-up period.</jats:p> - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Tumour Lymphocytic Infiltration, Its Structure and Influence in Colorectal Cancer Progression(Scientific Foundation Spiroski, 2018); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synchronous occurrence of ileal stromal tumor (GIST) and colonic adenocarcinoma: a case report.(2015); ; ; Introduction: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract. There is an increasing number of literature reports on synchronous occurrence of gastrointestinal stromal tumors and another malignancy of distinct etiology and evolution. The most reported cases include gastric synchronous occurrence of gastrointestinal stromal tumors and adenocarcinoma and gastric gastrointestinal stromal tumors and colonic adenocarcinoma. Case report: We present a case of a 77-old female, with synchronous cecal moderately differentiated adenocarcinoma in Stage IIA according to the TNM classification and ileal spindle cell type GIST with low malignant potential, positive for c-Kit, CD34, vimentin, Actin, and negative for S100. Conclusion: The synchronous occurrence of small bowel gastrointestinal stromal tumors and other primary gastrointestinal malignancies has been rarely reported. There is a need of further investigations to identify the relationship between gastrointestinal stromal tumors and colorectal cancers. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Sentinel Lymph Node Detection in Breast Cancer – First Experience(Macedonian Academy of Sciences and Arts / Walter de Gruyter GmbH, 2015-05-01); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Calcification of the cavernosal bodies may be responsible for development of erectile dysfunction in uremic apolipoprotein E deficient (apoE-/-) mice(Elsevier BV, 2019-12-30); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Impact of Size of the Tumour, Persistence of Estrogen Receptors, Progesterone Receptors, HER2Neu Receptors and Ki67 Values on Positivity of Axillary Lymph Nodes in Patients with Early Breast Cancer with Clinically Negative Axillary Examination(2017-12-15); ; ; ; The study aimed to identify factors that influence the positivity of axillary lymph nodes in patients with early breast cancer and clinically negative axillary lymph nodes, who were subjected for modified radical mastectomy and axillary lymphadenectomy. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EP778 The role of the E-cadherin/β-catenin signal transduction pathway in the prognosis of advanced stage high-grade serous ovarian/fallopian tube cancer(BMJ Publishing Group Ltd, 2019-11); ; ; ; Introduction/Background The aim of the study was to evaluate the correlation between E-cadherin/β-catenin expression and the clinical and pathological parameters that influence the overall survival rate in patients with advanced stage high-grade serous ovarian/fallopian tube cancer Methodology We performed a retrospective cohort study on patients that underwent primary debulking surgery at the University Clinic of Gynecology and Obstetrics, University ‘Ss. Cyril and Methodius’, Skopje, Republic of North Macedonia between January 2010 and December 2015. The following disease characteristics were analyzed: age, stage, nuclear and tumor grade, lymphovascular invasion, the extent of primary debulking, platinum-based chemotherapy resistance and overall survival. Further, we analyzed the expression of E-cadherin/β-catenin by preforming immunohistochemical staining on deparaffinized and rehydrated tissue specimens with specific monoclonal antibodies. Results A total of 84 patients with primary ovarian and 9 patients with primary fallopian tube cancer met the inclusion criteria. The overall survival of patients in the analyzed cohort was 46 months (95% CI 38–53 months). The residual tumor volume after primary debulking surgery was an independent bad prognostic factor with HR=5.32 (p<0.001). The low frequency of expression as well as the weak staining for E-cadherin were independent bad prognostic factors for the survival of these patients with HR=2.7 (p=0.05) and HR=3.38 (p=0.04), respectively. The univariate analysis also identified that the low frequency of expression and weak staining for β-catenin were bad prognostic factors, but the significance was lost in the multivariate analysis. Conclusion In this study, we identified that the residual tumor volume after primary debulking surgery and the low frequency of expression and weak staining for E-cadherin were independent, statistically significant bad prognostic factors for the overall survival of patients with advanced stage high-grade serous ovarian/fallopian tube cancer. Beta catenin expression was not found to be an independent prognostic factor in the multivariate analysis. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Poster: AML-327: Plasmacytoid Dendritic Cell Proliferation Associated with Acute Myeloid Leukemia: A Case Report(Elsevier BV, 2021-09); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, MONOMORPHIC EPITHELIOTROPIC INTESTINAL T-LYMPHOMA – CASE REPORT(Scientific Foundation SPIROSKI, 2022-06-28); ; ; Karanfilska, AleksandraBackground: Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II) is an extremely rare peripheral T-cell lymphoma that involves the malignant proliferation of a T- lymphocyte in the gastrointestinal tract. Over time, these T cells commonly spread throughout the mucosal lining of a portion of the GI tract (particularly the jejunum and ileum of the small intestine), lead to GI tract nodules and ulcerations, and cause symptoms such as abdominal pain, weight loss, diarrhea, obstruction, bleeding, and/or perforation. Its clinical, morphologic, and immunophenotypic features distinguishing it from the more common Enteropathy Associated T-Lymphoma (previously EATL type I) made it a separate entity. Case report: We present a case of a rare extremely aggressive T cell lymphoma that originates from the gastrointestinal tract, spreads to surrounding organs and is refractory to surgery and chemotherapy. We describe а case report of 79 years old patient with clinical features of acute abdomen, ileus, treated with surgery two times. During the first surgery partial resection of jejunum was performed. Pathohistology and immunоhistochemistry findings of MEITL. PET/CT scan revealed infiltration of intestinum, uterus, ovarium. During the second operation partial resection of ileum and hysterectomy with adnexectomy was performed. The patient is treated with antracycline-based regimen CHOP21 (4 cycles). Re-evaluation with second PET/CT scan revealed residual tumor on the intestinum and bladder. The patient deteriorate with acute renal failure and multi-organ failure. Despite aggressive treatment with extensive surgery and aggressive anthracycline-based chemotherapy, in a short time the tumor spread to surrounding organs (sigma, bladder). The patient survived 11 months from the initial definitive diagnosis. Conclusion: MEITL is a challenging primary intestinal T cell lymphoma to treat as the outcome is frequently poor despite surgery and chemotherapy. Most patients are elderly with co-morbidities and they usually present late rendering any therapy ineffective. Young age, early Ann-Arbor/Lugano disease stage, good performance scale status, patients receiving autologous stem cell transplantation and less bulky disease are associated with an improved survival outcome. Further research is needed to incorporate new therapeutic modalities based on molecular research for successful treatment of this aggressive lymphoma.</jats:p>