Stojkovic, Jagoda
Preferred name
Stojkovic, Jagoda
Official Name
Stojkovic, Jagoda
Main Affiliation
22 results
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Item type:Publication, Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report)(Scientific foundation Spiroski, 2016-12-15); ; ; Dragana StojkovicBACKGROUND: Goodpasture syndrome was originally described as an association of alveolar haemorrhage and glomerulonephritis. It occurs when the immune system attacks and destroys healthy body tissue. AIM: We are presenting a patient with a clinical picture of pulmonary haemorrhage and glomerulonephritis, which is diagnosed by renal biopsy. CASE PRESENTATION: His illness began a year and a half before being diagnosed. In that period he had occasional exacerbations. He was received at our Clinic in extremely serious condition, and after stabilisation of his medical condition, there was made a biopsy of the kidney. The p-ANCA was 8.93 U/ml (neg < 3, poz > 5 U/ml). Histopathological diagnosis of biopsy of the kidney was: Glomerulonephritis extra capillaries focalis, segmentalis et globalis. Based on this he was diagnosed with Goodpasture syndrome. He received corticosteroid therapy and cyclophosphamide, with good response to treatment, and he is currently in a stable condition, receiving only corticosteroid therapy. CONCLUSION: Goodpasture syndrome is a severe illness caused by the formation of antibodies to the glomerular basement membrane and alveolus with consequential damage to renal and pulmonary function. With current therapy, long-term survival is more than 50% - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Barriers and factors that facilitate the use of long-term oxygen therapy at home and the quality of life of patients with COPD(Association of Traditional Chinese Medicine and Acupuncture Tong Da Tang TCM, Skopje R.N. Macedonia, 2024); ; Aleksandra StefanovskaBackground: Long-Term Oxygen Therapy (LTOT) is a critical intervention for managing chronic obstructive pulmonary disease (COPD) in patients with severe hypoxemia. Despite its clinical benefits, the effective use of LTOT at home faces numerous barriers and facilitating factors that significantly influence the quality of life (QoL) of COPD patients. Objective: This study aims to explore the barriers and factors that influence the use of LTOT at home, as well as its impact on the quality of life of COPD patients Methods: Through a comprehensive review of the literature, we identify the challenges and facilitators associated with LTOT use, along with the factors that contribute to the quality of life of patients. A mixed-methods approach was utilized in this study, involving qualitative data from semi-structured interviews with patients, caregivers, and healthcare providers. The study included a cohort of COPD patients on LTOT, assessing their experiences and QoL over a specified period. Results: Key barriers to effective LTOT use at home included physical limitations, social stigma, equipment management issues, and insufficient patient education. Facilitating factors identified were robust social support, comprehensive education programs, and regular follow-up with healthcare providers. Conclusion: Understanding the barriers and facilitating factors in the use of LTOT at home is essential for enhancing adherence and improving the QoL of COPD patients. Tailored interventions that address these barriers and leverage facilitating factors can lead to more effective LTOT use and better patient outcomes. This study highlights the importance of a holistic approach in managing COPD, incorporating both medical treatment and supportive measures to optimize patient well-being. The findings provide valuable insights into enhancing the effectiveness of LTOT at home and improving the overall well-being of individuals living with COPD. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Nt-proBNP DISCRIMINATORY ROLE BETWEEN SYMPTOMATIC AND ASYMPTOMATIC PATIENTS WITH SEVERE VALVULAR AORTIC STENOSIS(Macedonian Academy of Sciences and Arts, 2018-08-13); ; ; Nikola Hadzy-PetrushevBackground: The aim was to evaluate the Nt-proBNP discriminatory role between symptomatic and asymptomatic patients with severe aortic stenosis. Methods: 187 patients with severe valvular aortic stenosis, with normal EF > 50%, were included, 61 asymptomatic and 126 symptomatic. We used clinical, laboratory (Nt-proBNP) and echocardiographic parameters. Endpoints of monitoring (occurrence of event) were: the onset of symptoms in asymptomatic patients and death in both groups. Results: The symptomatic group with severe AS had a significantly higher means of Nt-proBNP, in comparison with the asymptomatic group. Nt-proBNP was a significant predictor for the risk of event occurrence (HR 1.4). In the group of severe AS without CAD (n = 101), the subgroup with Nt-proBNP above the cut-off value, took significantly higher percentage of patients with chest pain, fatigue and syncope. In the group with Nt-proBNP above the cut-off value, we had a significantly higher percentage of patients with severe AS without CAD, compared to those with CAD (n = 142). Nt-proBNP was negatively correlated with AVA and LVEF, whether the positive correlation was expressed for: LVEDd, LVEDs, IVSd, AV_Vmax, AV_MaxGrad, LVM and LA. Patients with Nt-proBNP above the cut-off, had a significantly lower event free survival, compared to patients with Nt-proBNP below the cut-off (n = 187; n = 101). Conclusion: The Nt-proBNP cut-off> 460 pg/ml was confirmed as a useful tool in the determination of event free survival in patients with severe AS. Nt-proBNP not only had relevance in the assessment of the severity of the disease, but also was a significant predictor for the risk of event occurrence. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, QUALITY OF LIFE, FORCED EXPIRATORY VOLUME IN ONE SECOND AND BODY MASS INDEX IN PATIENTS WITH COPD, DURING THERAPY FOR CONTROLLING THE DISEASE(Macedonian Academy of Sciences and Arts, 2009); Stevcevska G.Abstract: Patients with chronic obstructive pulmonary disease (COPD) are characterized by an impaired lung function and limited exercise tolerance. Medication and rehabilitation programmes are generally directed towards relief of symptoms and improvement of lung function and exercise tolerance. 130 patients were included in the examination with diagnosed chronic obstructtive pulmonary disease, stable form, 114 male and 16 female, of whom 121 were smokers and 9 were non-smokers. Inclusive criteria were FEV1 < 50% from predicted (with moderate and severe level of the disease), the relation FEV1/FVC < 70%, the test of reversibility with β2-agonist < 15%. The patients were followed up for 18 months. They were evaluated at the start, and then at the end of the study. During the examination 9 patients were excluded because they did not obey recommendations of the examination, and three patients died during the examination. At the end of our study 77 patients in group I, 66 male and 11 female, were evaluated, and 41 patients, 35 male and 6 female, in group II. The patients were divided on the basis of BMI (body mass index), group I with BMI from 21 to 28 kg/m2 and group II with BMI < 21 kg/m2 . The mean age of the patients was 63 ± 7.2 years in group I, and 68 ± 8.3 in group II. The values of FEV1 at the start were 1.33 ± 0.35L (43 ± 8.1%) in group I, and 0.89 ± 0.27 L (28 ± 7.9%) in group II. Both were significantly lower in group II (p < 0.001). At the end of the study the values of FEV1 were lower in both groups than at the start (Fig. 1). At the start of the study SGRQ scores in group I were significantly lower (p < 0.001) than in group II. This indicated a better quality of life in patients with BMI from 21 to 28 kg/m2 . The SGRQ scores at the end of the study were also significantly lower in group I (p < 0.001). And they were lower than at the start in both groups, indicating a better quality of life in patients with COPD after18 months’ regular use of therapy (Fig. 2). The values of Pearson’s coefficient r = -0.49 (p < 0.05) in group I and r = -0.35 (0.05) in group II, shows that between these two variables there is an indirect, or negative correlation; lower values of FEV1 are associated with higher SGRQ total scores. It can be concluded that regular use of therapy for controlling the disease leads to improved quality of life in COPD patients, which is not associated with improvement in lung function. Patients with malnutrition (BMI < 21kg/m2 ) have lower values of FEV1, and they have higher SGRQ scores of quality of life. High levels of SGRQ scores are associated with lower values of FEV1. Key words: COPD, therapy, quality of life, forced expiratory volume in one second, body mass index. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Prevalence of Diabetes Mellitus in COPD Patients with Severe and Very Severe Stage of the Disease(ID-Design/Scientific foundation SPIROSKI, 2016-05-22); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Level of Cholesterol in COPD Patients with Severe and Very Severe Stage of the Disease(Scientific foundation Spiroski, 2016-06-15); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The effect of smoking on lung function and respiratory symptoms in population of 25-40 years who worked in state administration(Здружение на физиолози и антрополози на Македонија, 2016); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Prevalence of Diabetes Mellitus in COPD Patients with Severe and Very Severe Stage of Disease(Scientific Foundation SPIROSKI, Skopje, 2016-05-22); ; ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Female patient with sarcoidosis first diagnosed with asthma (case report)(Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2016); Abstract Introduction: Sarcoidosis is a disease in which are present restrictive changes, the functional properties of lung and reduced values of diffusion capacity. Some authors showed the presence of airway obstruction in 2/3 of patients with a confirmed diagnosis of sarcoidosis who were not smokers. Case presentation: A female patient IT, from Skopje, born 09.16.1983 year, pharmacy technician, employed, non-smoker, does not consume alcohol, denied food or drugs allergies.Complaining of shortness of breath, cough with scant sputum, wheezing, the appearance of red spots on the legs, mutual, which withdrawn after two weeks. First she was diagnosed as asthma and a therapy was recommended.Her health situation has not improved and then a computered tomography of lung was performed. After that a bronchoscopy was performed and sarcoidosis histopathological was confirmed. She received corticosteroid therapy for one year, and her health situation become better. Conclusions:Sarcoidosis should be considered in the differential diagnosis of poorly responsive asthma. Obstructive symptoms resulting from airway involvement can occur in patients with pulmonary sarcoidosis but less frequently than a decrease in DLCO and restrictive disease. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Overweight and obesity: prevalence and effect on asthma control(Македонско лекарско друштво, 2016); ; ; Debreslioska A.
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