Babulovska, Aleksandra
Preferred name
Babulovska, Aleksandra
Official Name
Babulovska, Aleksandra
Translated Name
Александра Бабуловска
Alternative Name
Aleksandra Babulovska
Babuloska Aleksandra
Aleksandra B
Babulovska A
Babuloska A
A Babulovska
Бабуловска,Александра
Main Affiliation
Email
aleksandra.babulovska@medf.ukim.edu.mk
59 results
Now showing 1 - 10 of 59
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Item type:Publication, Cardiovascular toxicity in acute tricyclic antidepressant (Amitriptyline) overdose(Elsevier BV, 2006-09) - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CLINICAL AND BIOCHEMICAL FINDINGS OF RHABDOMYOLYSIS IN ACUTE INTOXICATIONS WITH PSYCHOACTIVE AND CHEMICAL SUBSTANCES(2020); ; ; ; The aim of the study is to identify possible differences in demographic, laboratory and clinical characteristics between patients with rhabdomyolysis due to intoxication with psychoactive and chemical substances. The study is a cross-sectional study conducted between 1 January and 30 June 2019. All the patients included during this period were treated due to intoxication (outpatient or hospitalized) at the University Clinic of Toxicology in Skopje. The patients with rhabdomyolysis were divided in two groups according to the nature of the substance used for intoxication: a) psychoactive substances and b) a chemical substance. Rhabdomyolysis was determined with a value of CPK (creatinine phosphate kinase) >250 U/L. Patients with rhabdomyolysis due to intoxication with chemical substances were significantly older than patients with rhabdomyolysis due to intoxication with psychoactive substances. There is a significant difference between the two groups of patients with rhabdomyolysis in terms of CPK, urea, hemoglobin values during the first day with regards to significantly higher values in the group where intoxication occurred with psychoactive substances. Five patients with rhabdomyolysis due to intoxication with psychoactive substances experienced muscle pain (10.9%), and one patient (3.8%) of those with rhabdomyolysis due to intoxication with chemicals, without any significant association between muscle pain and type of intoxication (Fisher exact test: p=0.3003). Muscle weakness and pigmented urine were identified consequently in six patients (13.0%) vs. five (10.9%) of patients with psychoactive intoxication and none with chemical. Rhabdomyolysis caused by psychoactive and chemical substances is associated with clinical manifestations and biochemical abnormalities. The values of CPK, myoglobin, AST, ALT, LDH, urea and creatinine were higher in favor of the group of intoxicated patients with rhabdomyolysis with psychoactive substances. The clinical symptoms of rhabdomyolysis are not present in all intoxicated patients, but are more present in the group intoxicated with psychoactive substances. Biochemical findings are crucial in establishing the diagnosis of rhabdomyolysis. Abnormalities of biochemical findings need to be identified in order to initiate appropriate treatment immediately to prevent mortality and morbidity. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Heroin dependence duration influences the metabolic parameters: mechanisms and consequences of impaired insulin sensitivity in hepatitis C virus seronegative heroin dependents(Hagerstown, MD : Lippincott Williams & Wilkins, 2012-12); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Program of the University Clinic of Toxicology, Skopje, Republic of Macedonia in treatment of drug addiction (buprenorfin treatment protocol)(ScopeMed Publishing, 2011); ; ; Irena JurukovThe program of our Clinic includes, not only treatment of acute intoxication with opioids and other drugs, but also comprehends clinical investigations and treatment of the somatic complications of this population. For the first time in our country our Clinic offers to this population the alternative way of treatment with Buprenorfin. The Clinic started with this protocol on August 1, 2009. During a period of two years, the treatment with Buprenorfine has been initiated in 353 patients, of which 211 regularly attend the medical check ups. This model is used according to the national clinical guidelines and procedures for the use of buprenorfine in the treatment of opioid dependence The dose of this medicament depends on the evolution of the withdrawal symptoms. We have used the objective and subjective opioid withdrawal scale for the observation of these symptoms (OOWS ; SOWS - Handelsman et al 1987). This protocol starts with a complete clinical investigations, (i.e. where all patients undergo the inclusion and exclusion criteria with a written consent). Afterwards, the patients are hospitalized and start with a Buprenorfin teratment. After period of 7-10 days hospitalization they come to our Clinic, like outpatients for a regular controls. We have precise evidence for every patient who comes for control (e.g. medical record with all biochemical and toxicological screenings). All patients are recommended a tight cooperation with psychiatrists who are specialized to treat the problematic drug addictions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ТЕРАПИСКИ ПРИСТАП СО БУПРЕНОРФИН ОДНОСНО МЕТАДОН КАЈ ЗАВИСНИЦИ ОД ХЕРОИН(2015); ; ; Oвој труд има за цел да ги спореди искуствата од терапискиот пристап со бупренорфин односно метадон при зависност од хероин. Maтеријал и методи: Истражувањето е проспективно рандомизирано, контролирано. Спроведено е на Универзитетската Клиника за Токсикологија и Центарот за зависности. Со истражувањето се опфатени вкупно 140 зависници од хероин поделени во две групи од по 70 испитаници кои минимум три месеци пред почетокот на истражувањето биле доброволно вклучени на супституционен третман со бупренорфин (испитувана група) односно метадон (контролна група). Во двете групи следена е: просечната доза на одржување како и влијанието на времетраењето на зависноста од хероин врз висината на просечната доза на одржување. Резултати: Постои сигнификантна разлика од две години (t-test<0,05), во однос на просечното времетраење на злоупотребата на хероин помеѓу испитуваната (5,9±2,3) и контролната група (7,8±2,4). Согледана е позитивни, односно директни корелација помеѓу просечното времетраење на користење на хероин и просечната доза на одржување на бупренорфин односно метадон при третман на хероински зависници. Заклучок: Соодветната доза на бупренорфинот и метадон во индукционата фаза е критичниот фактор за успешноста во лекувањето на хероинските зависници. Ниските дози на бупренорфин и метадон во фазата на оджување ја зголемуваат “гладта“ за хероин, со што се објаснува зголемениот процент на рецидиви. Постои позитивна корелација помеѓу историјата на просечното времетраење на користење на хероин и просечната доза на одржување на бупренорфин односно метадон при третман на хероински зависници - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Influence of Duration of Heroin Dependence on Humoral Immunologic Indicators(American Society of Addiction Medicine, 2016-06); ; ; ; Irena JurukovObjective: The incidence of autoantibodies may be associated with the duration of drug use. In this study, we assessed the association between the duration of heroin dependence and various humoral immunologic indicators, including IgA, IgG, IgM, complement component 3, complement component 4, rheumatoid factor, antib2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating immune complexes, and cryoglobulins. Methods: A total of 363 patients with heroin dependence were enrolled in this cross-sectional and prospective study over a 3.5- year period. Depending on the duration of heroin use, participants were divided into 3 groups: up to 3 years, 4 to 7 years, and more than 7 years of heroin dependence. All patients were analyzed for the indicators. Results: There was a significant difference between the duration of heroin dependence and increased concentration of IgA (P ¼ 0.0000), IgG (P ¼ 0.0000), IgM (P ¼ 0.0001), complement component 3 (P ¼ 0.042), rheumatoid factor (P ¼ 0.0001), anti-b2-glycoprotein 1 (IgA, P ¼ 0.0098; IgG, P ¼ 0.0000; IgM, P ¼ 0.0000), the presence of antinuclear antibody (P ¼ 0.01) and cryoglobulins (P ¼ 0.0000), and decreased concentration of complement component 4 (P ¼ 0.002). There was no significant difference in circulating immune complex concentration (P ¼ 0.097). Conclusions: A longer duration of heroin dependence was associated with increased concentrations of IgA, IgG, IgM, complement component 3, rheumatoid factor, anti-b2-glycoprotein 1 (IgA, IgG, IgM), presence of antinuclear antibodies and cryoglobulins, and decreased concentrations of complement component 4, but there was no influence on circulating immune complex values. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Physical birth outcomes in neonates prenatally exposed to buprenorphine – our first experiences(2019-09-17); ; Introduction/Objective Buprenorphine appears generally similar to, and in some cases superior to, methadone in terms of maternal, fetal, and neonatal outcomes. The objective of the study was to assess some physical birth outcomes in neonates prenatally exposed to buprenorphine. Methods During a seven-year period, nine patients have been treated with buprenorphine during their pregnancy. All women underwent interview, clinical investigations, biochemical analysis, toxicological screening, viral markers for hepatitis B, C, HIV, with regular check-ups by an obstetrician and a psychiatrist. Newborn outcomes included: birth weight in grams, birth length in centimeters, physical anomalies, head/chest circumference in centimeters, Apgar score at 1 minute / 5 minutes, gestational age (weeks), newborn length of hospital stay in days, breast-feeding, the newborn’s need for pharmacologic treatment after delivery. Results The mean birth weight was 2,991.11 ± 37 g; birth length was 49.44 ± 2.29 cm; head circumference was 33.11 ± 0.78 cm; chest circumference was 32.33 ± 1 cm; first minute Apgar score was 8.22, fifth minute 9.22; age at delivery was 38.77 ± 1.09 weeks; hospitalization after delivery 4.44 ± 1.13 days. None of the newborns had physical anomalies. Six of the newborns were breastfed. Conclusion Buprenorphine is a safe and important part of a complete comprehensive treatment approach in pregnant women with opioid use disorder. Buprenorphine treatment of maternal opioid use disorder indicated a low risk of preterm birth, normal birth weight and length, head and chest circumference, Apgar score, short hospitalization after delivery. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Acute severe poisoning with disinfectant in senior aged patient-case report and overview of literature considering age influence on treatment decision in alcohol-based intoxications(2021); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Role of Urgent Esophagogastroduodenoscopy in Prognosis of Acute Caustic Poisonings(Academy of Medical Sciences of Bosnia and Herzegovina, 2011); ; ; Vesna ChibishevaIntroduction: Ingestion of corrosive substances causes severe lesions to the upper gastrointestinal tract. The aim of this paper was to present our clinical experience with the 4-grade endoscopic classification of post-corrosive injuries in prognosis of the outcome in acute caustic poisonings. Material and methods: This was a retrospective study comprising 33 patients with grade II B and III injury hospitalized at the University Clinic for Toxicology in Skopje, Republic of Macedonia in the period 2008-2009. The grade of injury was determined with urgent esophagogastroduodenoscopy performed in the first 12-24 hours. After treatment the patients were followed for a minimum of six months. Results: A total of 33 patients were analyzed. At the time of hospital admission post-corrosive injuries of grade III predominated (n=22, 66.67%) and post-corrosive injuries of grade II B (n=11, 33.33%). The most common late postcorrosive complications of the esophagus was stenosis esophagei (n=19, 57.58%). The most common post-corrosive damages of the stomach were: stenosis antropylori (n=10, 30.30%), stenosis pylori (n=6, 18.18%) and stenosis antri (n= 3, 9.09%). Conclusion: Urgent esophagogastroduodenoscopy has to be done in all acute caustic poisonings in the first 12-24 hours and they are to be classified according to Kikendall’s four-grade classification. The classification in four grades of post-corrosive injuries to the upper gastrointestinal tract might help in therapeutic approach and prognosis of the outcome - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Non-Opioid Substances Acute Poisonings with Suicidal Intent in Patients with Opioid Use Disorder(2020-03-31); ; Introduction: Several epidemiological studies have evaluated the role of illicit drug use in suicide behaviour. Aim: To assess patients with opioid use disorder and suicidal intent related to behavior, severity of acute poisoning and the most commonly used non-opioid substances. Materials and methods: This cross sectional study included 67 patients diagnosed with opioid use disorder. The study was conducted at the University Clinic of Toxicology in Skopje over a 5-year period (2013-2017). The following variables were examined: gender, age, duration and route of opioid administration, duration of hospitalization, and types of substances used in acute poisoning. Assessment of patients’ behavior and severity of poisoning was made by using the Suicide Behaviours Questionnaire-Revised and the Poison severity score. Results: The majority of patients were male (88.1%). The mean age of patients was 30±6.1 years. The average duration of opioid use disorder was 8.5±3.9. A single poisoning was found in 62.7%, double poisoning in 25.4%, and triple poisoning in 11.9% of participants. Benzodiazepines were most commonly used by the patients (55.2%). The largest number of patients (32.8%) had minor Poison severity score (PSS), and only 17.9% had severe PSS. None of the patients had a fatal suicide attempt. 86.6% of patients had a score of ≥7 indicating a high risk of repeat suicide attempts. Conclusion: Benzodiazepines were most commonly used as a single or combined substance in patients with opioid use disorder. PSS indicated that most of the participants were with minor PSS and with high risk of a repeat suicide attempt.