Krstevska konstantinova, Marina

Preferred name
Krstevska konstantinova, Marina
Official Name
Krstevska konstantinova, Marina
Main Affiliation
Email
marina.krstevska.konstantinova@medf.ukim.edu.mk

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    ASSOCIATION OF POLAND SYNDROME AND HYPERTRICHOSIS IN A PUBERTAL GIRL - Case report
    (Institute of Public Health of the Republic of North Macedonia = Институт за јавно здравје на Република Северна Македонија, 2021-06-30)
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    Hristijan Nestorov
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    Poland syndrome (PS) is a rare congenital malformation, most commonly characterized by absence of chest wall muscles on one side of the body. It may be accompanied with other deformities of the extremities. We present the case of a 10-year-old girl with Poland syndrome and hypertrichosis of the back of the trunk and extremities. The clinical examination did not reveal the etiology of the syndrome, such as familial predisposition or some event that led to interrupted blood flow during the early embionic growth. The pregnancy was concieved with in vitro fertilization (IVF); triplets were born and our patient is one of these three girls. The hypertrychosis appeared at 8 years of life, without evidence of previous familial occurance, medications or hormonal disbalance. Other malformations that were found were: a mild form of kyphoscoliosis and mitral valve prolapse. The child was evaluated using a multidisciplinary approach, with further follow-up planned with surgical correction of the chest wall and breast augmentation.
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    Two cases of non-syndromic congenital unilateral breast hypoplasia in one family
    (Institute of Public Health of the Republic of North Macedonia = Институт за јавно здравје на Република Северна Македонија, 2020-02-20)
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    Ana Stamatova
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    Micromastia or breast hypoplasia is described as underdevelopment of a woman’s mammary tissue. We present the case of a 15-year-old girl with unilateral micromastia, with familial predisposition. Ultrasound, hormonal, dysmorphic, cardiologic, genetic examinations and testing were performed. No mutation in the whole- exome sequencing was found, nor novel mutation. Some of these cases have been reported to be related to breаst cancer so further follow-up is mandatory. Therapy consists of surgical reconstruction of the affected breast. This is a rare condition and it requires a multidisciplinary approach.
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    Autoimmune thyroiditis after long term gonadotropin- releasing hormone agonist treatment for central precocious puberty: case report
    (Институт за јавно здравје на Р Северна Македонија = Institute of Public Health of R North Macedonia, 2020-02-20)
    Maja Tankoska
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    Avdi Murtezani
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    There is a small number of studies that have reported abnormalities in endocrine function after a long-term gonadotropin-releasing hormone agonist (GnRHa) treatment in girls. This treatment is considered as safe and effective by most authors. We report our second case of unusual outcome of long-term GnRHa therapy in a girl with central precocious puberty (CPP) of idiopathic or familial etiology. She has received monthly depot of injections of triptorelin for a time period of 4 years. We have examined thyroid function by measuring serum levels of thyrotropin (TSH), thyroxine (T4), thyroid antibodies and ultrasound of thyroid gland. At the age of 11 years she developed a mild goiter and presented with autoimmune thyroiditis, having elevated thyroid antibodies and ultrasound of thyroid gland typical for Hashimoto thyroiditis. Having in mind these two cases, we suggest a closer monitoring of thyroid function in girls with CPP, before and during therapy with GnRH agonist.
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    Four generations in a family with neurofibromatosis 1: precocious puberty and optic nerve tumor (OPT)
    (Macedonian Academy of Sciences and Arts, 2010)
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    Jancevska, Aleksandra
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    Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with varied clinical manifestations. The proband is a 6-year-old boy with signs of precocious puberty. His penis was 10 cm, testicles 8 ml, pubic hair P2-3, and the genital skin was hyperpigmented. Multiple cafe au lait spots well above 5 mm were noticeable on his skin, as well as hard subcutaneous nodules, mostly on his trunk. His intelligence and hearing are normal. He has no history of seizures. Laboratory analysis showed: LH LH 1.4 mIU/ml, FSH 6.2 mIU/ml, testosterone 183 ng/ml. Bone age was 9 years. LHRH stimulation was characteristic of true precocious puberty (LH 9.8 mIU/ml and FSH 8.9 mIU/ml after 30 minutes). The MRI of the brain showed a tumor of the suprasellar region with compression of the pituitary stalk. At present the boy is 6 years old and has been treated with triptoreline acetate for 3 months. The volume of the testicles has decreased to 7 ml and a slight loss of pubic hair was noted. In addition, his mother and his grandfather exhibited dermal masses, and focal cutaneous and subcutaneous growths. The great-grand father had had the same cutaneous changes and died at the age of 75 from unrelated causes. It has already been well documented that NF is associated with an increased risk of malignancy and precocious puberty. Hence, we emphasize the need for a close and regular clinical follow-up of the OPT, puberty and patterns of growth.
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    Organochloride Pesticides in Macedonian Girls With Premature Sexual Development
    (Walter de Gruyter GmbH, 2007-04-01)
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    C Charlier
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    J Bourguignon
    Premature sexual development (PSD) in girls describes the appearance of secondary sexual signs before the age of 8 years. Early puberty is diagnosed if pubertal signs appear between the age of 8 and 9 years. We found a positive association between the levels of organochloride pesticides (p,p'-DDE) in precocious puberty in girls adopted from developing countries and significantly higher levels than in native Belgian girls with the same condition.</jats:p><jats:p>We have compared the serum levels of eight p,p'- DDE in 56 Macedonian girls with PSD and a control group of 24 normal, age-matched girls, using a gas chromatographic analyzer coupled to a tandem mass spectrometer detector. Of the 56 girls with PSD, 42 had premature thelarche, five had early puberty, and nine had precocious puberty of idiopathic (<jats:italic>n</jats:italic> = 8) or organic (<jats:italic>n</jats:italic> = 1) origin. We found traces of p,p'- DDE in nine girls (16%) and negative results in 41 (73%), while the remaining six (10%) had a mean level of 1.17 ± 0.7 μg/L. In the control group, traces were found in one girl (4%) and negative results in 18 (75%), while the remaining five (20%) had a mean level of 1.18 ± 0.6 μg/L. We found elevated levels of lindane in the girls with PSD (mean value 1.2 ± 0.8) and significantly higher levels in the control group (1.4 ± 0.8) (<0.05). We concluded that Macedonian girls with PSD do not have higher levels of p,p'-DDE in their serum than the normal controls. However, the elevated levels of lindane in this population should be further investigated.
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    Autoimmune thyroiditis and diabetes mellitus type 1 after long-term gonadotropin-releasing hormone agonist treatment for central precocious puberty: evolution or coincidence?
    (Walter de Gruyter GmbH, 2010-04)
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    Aleksandra Jancevska
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    Very few abnormalities in endocrine function have been reported during long term gonadotropin-releasing hormone agonist (GnRHa) treatment in girls. Most authors agree that this therapy is safe and effective. We present an unusual outcome of long term GnRHa therapy in two girls with central precocious puberty(CPP) of idiopathic or organic origin. They have received monthly depot injections of triptorelin acetate for a time period of 8 years. Thyroid function was examined by measuring serum levels of thyrotropin (TSH), thyroxine (T4), thyroid antibodies, and ultrasound of the thyroid gland. One of the girls was at the age of 8.5 years, having elevated thyroid antibodies, mild goitier and an abnormal ultrasound of the thyroid gland, suggesting autoimmune thyroiditis. Another girl with a hypothalamic hamartoma developed diabetes mellitus at the age of 9 years. Both of these girls were early diagnosed for CPP, at 6 months and 8 months respectively, and given GnRHa treatment. So far, it is not known whether these autoimmune diseases are related to the GnRHa treatment or are simply a coincidence. However, we suggest a closer monitoring of girls with CPP who have had a long period of treatment
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    Childhood craniopharyngioma in Macedonia: incidence and outcome after subtotal resection and cranial irradiation
    (Springer International Publ., 2011-02)
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    Ugrinovski, Jovica
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    Nastova, Vesna
    Craniopharyngioma is a frequent tumor in children with challenging surgical, endocrine, and visual consequences. We evaluated our experience in treating craniopharyngioma and its incidence in Macedonia.
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    Pericarditis in patients followed on rheumocardiology department in period of 2011-2016
    (Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2017)
    Neshkovska-Shumenkovska M
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    Jovanovska V
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    Pericard is double laided sheet of the heart. The inner serous layer (visceral pericard) is attached to the walls of the heart and on the great blood vessels makes duplicate and goes into fibrous layer (parietal pericard). Very tiny amount of pericard liqid is dividing two liflets of pericardium and that not allowed two liflets to come one to another.Acute pericarditis is the most common disease of the pericardium and it is from inflammatory etiology called pericarditis. Etiology of pericardits is usually viral, bacterial, .rheumatic, fever,.uremic or after cardio surgical treatment. Also neoplasm and tuberculosis can be reason for pericarditis.The aim: Aim of the state is to present different types of pericarditis treated on Cardio-rheumatological department in the Children Hospital in Skopje in period of 2011-2016. Materials and methods: We are presenting 13 patients who were hospitalized on our department. All patient were echocardiologically followed and have EKG following.We were realizing therapy with which we reached completely resolving of pericardial effusion. CONCLUSION. Pericarditis is inflammation with different etiology and pathophysiology and because of that exact diagnosis will lead to right treatment.