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    Outcomes of surgically treated distal radius fractures associated with triangular fibrocartilage complex injury
    (Elsevier B.V., 2020-09)
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    Study design: Prospective cohort. Introduction: Clinical studies that evaluate the correlation between associated lesions of the triangular fibrocartilage complex (TFCC) and outcome of distal radius fractures expressed with the patient-rated disability are missing. The purpose of this study was to evaluate the outcomes of distal radius fractures associated with or without an injury of the TFCC. Methods: Patients undergoing operative treatment for distal radius fracture were prospectively enrolled (n = 70). TFCC was examined by wrist arthroscopy and injuries classified according to Palmer. Comparative analyses were performed on 45 patients with TFCC injury (injured group) and 25 patients with intact TFCC (intact group). The outcome measures included the Patient-Rated Wrist Evaluation (PRWE) and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaires, 3 and 12 months after injury. Results: TFCC was injured in 45 patients (64%). In patients with intact TFCC, mean total PRWE score was 27 (3 months) and 16 (12 months), compared to patients with TFCC injury with 40 (at 3 months) and 24 (at 12 months). Mean DASH scores were 26 and 13 at 3 and 12 months for the intact group and 39 and 27 for the injured group. PRWE and DASH results showed significant difference at 3 and 12 months when compared with Mann-Whitney test. Discussion: PRWE and DASH scores evaluation showed that patients with associated TFCC injury had greater pain and disability at 3 and 12 months after injury. Conclusions: Disability outcomes were worse in patients with distal radius fracture, where TFCC was injured. TFCC injuries are an important cofactor affecting the outcome of distal radius fractures.
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    Identification of risk factors for lethal outcome in patients with severe community-acquired pneumonia
    (Medical Faculty, Ss. Cyril and Methodius University in Skopje, 2020)
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    Denkovska E
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    Aim of the study. To determine clinical and biochemical parameters as risk factors for mortality in patients with severe community-acquired pneumonia. Material and methods. A prospective, parallel group analysis of patients with community-acquired pneumonia, treated at the Intensive Care Unit of the University Clinic for Infectious Diseases in period of one year. A total of 42 adults (>=18 years) were enrolled, who were divides in two groups according to the outcome; survived and deceased. The outcome was defined as survival or death during the 30-day hospital treatment. Demographic, clinical as well as laboratory parameters were evaluated in all patients on admission. A statistically significant finding was considered if p<0,05. Results: The average age of patients was 61+15.2 years, and 33 (78.6%) were males. The overall mortality was 50%. In 29 (69%) patients a comorbid condition was registered, and comorbidity showed a statistical significance regarding the outcome. All had tachycardia, tachypnea and hypotension on admission, but impaired consciousnesses and shock were associated with mortality. Patients who died had a higher leukocyte count (15.9+11.8x109/L), higher procalcitonin levels (43.9+77.3 mg/ml), higher serum glucose levels (11.4+6.2 mmol/L) and lower PaO2/Fi O2 (122.64+ 52.8). Hyperglycaemia and hypoxia were the biochemical parameters that showed a statistically significant difference between the two study groups. Conclusion: Early identification of the risk factors for lethal outcome in patients with severe community acquired pneumonia enables implementation of adequate therapeutic measures, thereby decreasing the mortality in this group of critically ill patients.
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    Testicular infection in brucelosis: Report of 34 cases
    (Elsevier, 2018-02)
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    Silvana Miskova
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    Danco Balalovski
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    Background/Purpose To present clinical and laboratory features, treatment options, and outcome in patients with brucellar testicular infection and to compare them with analogous in brucellar patients without testicular involvement. Methods Thirty four brucellar patients with testicular infection treated in two general hospitals in the Republic of Macedonia, during the period 1998–2009, were retrospectively analyzed. Their clinical and laboratory characteristics were compared with analogous in 364 male brucellar patients without testicular infection, who were treated at the same hospitals during the same time period. Results Brucellar testicular infection was evident in 34 (8.5%) out of 398 male patients with brucellosis. The median age of the patients was 46.5 years. In all patients testicular involvement was presented as an acute form with a median duration of 5 days (range, 2–14 days) prior to diagnosis. Twenty-three of the patients had at least one other simultaneous focal infection. After starting with the treatment testicular infection lasted a median 10 days, range 7–21 days. Brucellar patients with testicular infection when compared with other brucellar patients more frequently manifested fever (97% vs. 61%), concomitant spondylitis (32% vs. 16%), and urinary system involvement (12% vs. 2%). Also, the relapse rate in patients with testicular involvement was significantly higher (24% vs. 9%). Conclusion In endemic regions brucellosis should be taken into consideration in any patient with testicular infection. Brucellar testicular involvement is usually characterized with a severe acute clinical presentation and a high percentage of relapses which entails the need of timely recognition and proper treatment duration of at least 60 days.
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    Upper Extremity Nerve Compression Syndromes – More Than Just a Carpal Tunnel Syndrome: A Review Article
    (Scientific Foundation SPIROSKI, Skopje, Republic of North Macedonia, 2025-05-10)
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    BACKGROUND: Besides carpal tunnel syndrome and cubital tunnel syndrome, other nerve entrapment sites in the upper extremity are less recognized. Only half of the upper extremity compression neuropathy syndromes are actually carpal tunnel and cubital tunnel compressions. This suggests that the rest of the entrapment syndromes are potentially not treated adequately. They are often misdiagnosed or the level of compression is not being distinguished. AIM: To raise awareness of compression syndromes (other than the carpal tunnel) in the arms and to describe the clinical triad to diagnose them. METHODS: This is a narrative review of the clinical features of the compression syndromes of the median, ulnar, and radial nerves in the upper extremities. The diagnostic triad for each syndrome is analyzed. The review focuses especially on the lacertus syndrome and describes the surgical release. CONCLUSION: A correct diagnosis is essential for targeted treatment of upper extremity nerve compression syndromes. It should also include an assessment of individual muscle strength, which is a critical part of the clinical neurological tests.
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    Outcome Evaluation of Arthroscopic Resection of Dorsal Wrist Ganglia
    (Macedonian Academy of Sciences and Arts, 2023)
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    Goals: Arthroscopic ganglionectomy has become an increasingly popular surgical option for dorsal wrist ganglia. The aim of this study was to describe our technique for the arthroscopic treatment of dorsal wrist ganglia and to evaluate the clinical results as well as the recurrence rate in our patients. Methods: In a prospective study, 48 patients who underwent arthroscopic treatment of dorsal ganglion of the wrist were included. Patients were evaluated preoperatively and 3 and 24 months post arthroscopy. A presence of recurrence at 24 months was recorded. The subjective outcome was evaluated with The Patient-Rated Wrist Evaluation (PRWE) and the Visual analog scale (VAS). Objective outcomes included grip strength and range of movement measurements. Results: The mean age was 36 years; the majority were women (36/48). Mean grip strength and the average flexion and extension in the wrist showed improvement after 3 months. The total PRWE score improved from 26.7 preoperatively to 10.2 at three months and 2.4 two years after surgery. After 24 months follow-up, there were only two patients with recurrence (4.2%). Conclusion: The arthroscopic resection of the dorsal wrist ganglia is a procedure with a low recurrence rate and lowest scaring and stiffness; it should be considered as a golden standard for operative treatment of the dorsal wrist ganglia.
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    Testicular infection in brucellosis: Report of 34 cases
    (Elsevier BV, 2018-02)
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    Miskova, Silvana
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    Balalovski, Danco
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    To present clinical and laboratory features, treatment options, and outcome in patients with brucellar testicular infection and to compare them with analogous in brucellar patients without testicular involvement. Methods: Thirty four brucellar patients with testicular infection treated in two general hospitals in the Republic of Macedonia, during the period 1998-2009, were retrospectively analyzed. Their clinical and laboratory characteristics were compared with analogous in 364 male brucellar patients without testicular infection, who were treated at the same hospitals during the same time period. Results: Brucellar testicular infection was evident in 34 (8.5%) out of 398 male patients with brucellosis. The median age of the patients was 46.5 years. In all patients testicular involvement was presented as an acute form with a median duration of 5 days (range, 2-14 days) prior to diagnosis. Twenty-three of the patients had at least one other simultaneous focal infection. After starting with the treatment testicular infection lasted a median 10 days, range 7-21 days. Brucellar patients with testicular infection when compared with other brucellar patients more frequently manifested fever (97% vs. 61%), concomitant spondylitis (32% vs. 16%), and urinary system involvement (12% vs. 2%). Also, the relapse rate in patients with testicular involvement was significantly higher (24% vs. 9%). Conclusion: In endemic regions brucellosis should be taken into consideration in any patient with testicular infection. Brucellar testicular involvement is usually characterized with a severe acute clinical presentation and a high percentage of relapses which entails the need of timely recognition and proper treatment duration of at least 60 days.